ENSG00000135596


Homo sapiens

Features
Gene ID: ENSG00000135596
  
Biological name :MICAL1
  
Synonyms : MICAL1 / microtubule associated monooxygenase, calponin and LIM domain containing 1 / Q8TDZ2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: q21
Gene start: 109444062
Gene end: 109465968
  
Corresponding Affymetrix probe sets: 218376_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000351664
Ensembl peptide - ENSP00000408924
Ensembl peptide - ENSP00000486901
Ensembl peptide - ENSP00000351385
Ensembl peptide - ENSP00000407075
NCBI entrez gene - 64780     See in Manteia.
OMIM - 607129
RefSeq - NM_001159291
RefSeq - NM_001286613
RefSeq - NM_022765
RefSeq Peptide - NP_001152763
RefSeq Peptide - NP_001273542
RefSeq Peptide - NP_073602
swissprot - Q8TDZ2
swissprot - H0Y6Z4
swissprot - Q5TED7
Ensembl - ENSG00000135596
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 E7F9T0ENSDARG00000011809Danio rerio
 MICAL1ENSGALG00000032190Gallus gallus
 Mical1ENSMUSG00000019823Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MICAL3 / Q7RTP6 / microtubule associated monooxygenase, calponin and LIM domain containing 3ENSG0000024315644
MICAL2 / O94851 / Q6ZW33 / microtubule associated monooxygenase, calponin and LIM domain containing 2ENSG0000013381635
Q8N3D4 / EHBP1L1 / EH domain binding protein 1 like 1ENSG0000017344215
Q8N3F8 / MICALL1 / MICAL like 1ENSG0000010013913
Q8IY33 / MICALL2 / MICAL like 2ENSG0000016487713
EHBP1 / Q8NDI1 / EH domain binding protein 1ENSG0000011550413
Q5M775 / SPECC1 / sperm antigen with calponin homology and coiled-coil domains 1ENSG0000012848712
Q69YQ0 / SPECC1L / sperm antigen with calponin homology and coiled-coil domains 1 likeENSG0000010001410
SMTN / P53814 / smoothelinENSG000001839639
SPECC1L-ADORA2A / SPECC1L-ADORA2A readthrough (NMD candidate)ENSG000002585558
Q2TAL5 / SMTNL2 / smoothelin like 2ENSG000001881766
A8MU46 / SMTNL1 / smoothelin like 1ENSG000002148725


Protein motifs (from Interpro)
Interpro ID Name
 IPR001715  Calponin homology domain
 IPR001781  Zinc finger, LIM-type
 IPR002938  FAD-binding domain
 IPR022735  bMERB domain
 IPR029937  MICAL1
 IPR036188  FAD/NAD(P)-binding domain superfamily
 IPR036872  CH domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0007010 cytoskeleton organization NAS
 biological_processGO:0007165 signal transduction NAS
 biological_processGO:0007596 blood coagulation TAS
 biological_processGO:0019417 sulfur oxidation IEA
 biological_processGO:0030042 actin filament depolymerization IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:1903305 regulation of regulated secretory pathway IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005882 intermediate filament NAS
 cellular_componentGO:0030496 midbody IEA
 cellular_componentGO:1990026 hippocampal mossy fiber expansion IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0004497 monooxygenase activity TAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen IEA
 molecular_functionGO:0017124 SH3 domain binding IPI
 molecular_functionGO:0017137 Rab GTPase binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0071949 FAD binding IEA


Pathways (from Reactome)
Pathway description
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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