ENSG00000135828


Homo sapiens

Features
Gene ID: ENSG00000135828
  
Biological name :RNASEL
  
Synonyms : Q05823 / ribonuclease L / RNASEL
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q25.3
Gene start: 182573634
Gene end: 182589256
  
Corresponding Affymetrix probe sets: 221287_at (Human Genome U133 Plus 2.0 Array)   229285_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000440844
Ensembl peptide - ENSP00000356530
NCBI entrez gene - 6041     See in Manteia.
OMIM - 180435
RefSeq - NM_021133
RefSeq Peptide - NP_066956
swissprot - Q05823
Ensembl - ENSG00000135828
  
Related genetic diseases (OMIM): 601518 - Prostate cancer 1, 601518
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RNASELENSGALG00000042986Gallus gallus
 Q05921ENSMUSG00000066800Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9ULH0 / KIDINS220 / kinase D interacting substrate 220ENSG0000013431319
ANKHD1-EIF4EBP3 / ANKHD1-EIF4EBP3 readthroughENSG0000025499619
O75179 / ANKRD17 / ankyrin repeat domain 17ENSG0000013246619
ANKHD1 / Q8IWZ3 / ankyrin repeat and KH domain containing 1ENSG0000013150319
TANC1 / Q9C0D5 / tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1ENSG0000011518318
TANC2 / Q9HCD6 / tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2ENSG0000017092118
ANKS6 / Q68DC2 / ankyrin repeat and sterile alpha motif domain containing 6ENSG0000016513817
Q9ULJ7 / ANKRD50 / ankyrin repeat domain 50ENSG0000015145816
Q8N6D5 / ANKRD29 / ankyrin repeat domain 29ENSG0000015406510
FANK1 / Q8TC84 / fibronectin type III and ankyrin repeat domains 1ENSG000002037808


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR002110  Ankyrin repeat
 IPR010513  KEN domain
 IPR011009  Protein kinase-like domain superfamily
 IPR018997  PUB domain
 IPR020683  Ankyrin repeat-containing domain
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006364 rRNA processing IEA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006468 protein phosphorylation NAS
 biological_processGO:0043488 regulation of mRNA stability IEA
 biological_processGO:0045071 negative regulation of viral genome replication IDA
 biological_processGO:0045444 fat cell differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0060337 type I interferon signaling pathway TAS
 biological_processGO:0060338 regulation of type I interferon-mediated signaling pathway TAS
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:0090501 RNA phosphodiester bond hydrolysis IEA
 biological_processGO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA
 biological_processGO:2001275 positive regulation of glucose import in response to insulin stimulus IEA
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005759 mitochondrial matrix TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016363 nuclear matrix IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0004521 endoribonuclease activity NAS
 molecular_functionGO:0004540 ribonuclease activity IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019843 rRNA binding IEA
 molecular_functionGO:0043021 ribonucleoprotein complex binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Interferon alpha/beta signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000006 Autosomal dominant inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele." [HPO:curators]
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 HP:0002664 Neoplasia "An organ or organ-system abnormality that consists of uncontrolled autonomous cell-proliferation which can occur in any part of the body as a benign or malignant tumour or neoplasm." [HPO:curators]
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 HP:0012125 Prostate cancer "A cancer of the `prostate` (FMA:9600)." [HPO:probinson]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000164163 ABCE1 / P61221 / ATP binding cassette subfamily E member 1  / complex / reaction
 ENSG00000196924 FLNA / P21333 / filamin A  / reaction / complex
 ENSG00000135828 Q05823 / RNASEL / ribonuclease L  / reaction / complex






 

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