ENSMUSG00000066800


Mus musculus

Features
Gene ID: ENSMUSG00000066800
  
Biological name :Rnasel
  
Synonyms : Q05921 / ribonuclease L (2, 5-oligoisoadenylate synthetase-dependent) / Rnasel
  
Possible biological names infered from orthology : Q05823 / ribonuclease L
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: G3
Gene start: 153749426
Gene end: 153764221
  
Corresponding Affymetrix probe sets: 10350742 (MoGene1.0st)   1426603_at (Mouse Genome 430 2.0 Array)   1426604_at (Mouse Genome 430 2.0 Array)   1446458_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000083385
Ensembl peptide - ENSMUSP00000138247
Ensembl peptide - ENSMUSP00000138734
Ensembl peptide - ENSMUSP00000138752
NCBI entrez gene - 24014     See in Manteia.
MGI - MGI:1098272
RefSeq - XM_011247994
RefSeq - NM_011882
RefSeq - XM_006529527
RefSeq - XM_006529528
RefSeq - XM_006529530
RefSeq - XM_011247993
RefSeq Peptide - NP_036012
swissprot - S4R2R4
swissprot - B2RQP1
swissprot - Q05921
swissprot - Q3T9T6
swissprot - S4R1J5
Ensembl - ENSMUSG00000066800
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RNASELENSGALG00000042986Gallus gallus
 Q05823ENSG00000135828Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kidins220 / kinase D-interacting substrate 220 / Q9ULH0*ENSMUSG0000003633320
Q99NH0 / Ankrd17 / Ankyrin repeat domain-containing protein 17 / O75179* / ankyrin repeat domain 17*ENSMUSG0000005520419
Ankhd1 / ankyrin repeat and KH domain containing 1 / Q8IWZ3* / ANKHD1-EIF4EBP3* / ANKHD1-EIF4EBP3 readthrough*ENSMUSG0000002448319
Tanc2 / A2A690 / Protein TANC2 / Q9HCD6* / tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2*ENSMUSG0000005358018
Tanc1 / Q0VGY8 / Protein TANC1 / Q9C0D5* / tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1*ENSMUSG0000003516817
Anks6 / Q6GQX6 / Ankyrin repeat and SAM domain-containing protein 6 / Q68DC2* / ankyrin repeat and sterile alpha motif domain containing 6*ENSMUSG0000006619116
Ankrd29 / ankyrin repeat domain 29 / Q8N6D5*ENSMUSG0000005776610
Fank1 / Q9DAM9 / Fibronectin type 3 and ankyrin repeat domains 1 protein / Q8TC84* / fibronectin type III and ankyrin repeat domains 1*ENSMUSG000000531117
Ankrd50 / ankyrin repeat domain 50ENSMUSG000000448640


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR002110  Ankyrin repeat
 IPR010513  KEN domain
 IPR011009  Protein kinase-like domain superfamily
 IPR018997  PUB domain
 IPR020683  Ankyrin repeat-containing domain
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0043488 regulation of mRNA stability IMP
 biological_processGO:0045071 negative regulation of viral genome replication ISO
 biological_processGO:0045444 fat cell differentiation IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051607 defense response to virus ISO
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:0090501 RNA phosphodiester bond hydrolysis IEA
 biological_processGO:2001275 positive regulation of glucose import in response to insulin stimulus IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003723 RNA binding ISO
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0004540 ribonuclease activity IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0043021 ribonucleoprotein complex binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Interferon alpha/beta signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000703 abnormal thymus morphology "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]
Show

Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0000708 thymus hyperplasia "increased cell number in the thymus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
Show

Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0000709 enlarged thymus "increased size of thymus" [J:50053]
Show

Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

Allelic Composition: Eif2ak2tm1Cwe/Eif2ak2tm1Cwe,Rnaseltm1Slvm/Rnaseltm1Slvm
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0006414 decreased T cell apoptosis "decrease in the number of T cells undergoing programmed cell death" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000058355 Abce1 / P61222 / ATP-binding cassette, sub-family E (OABP), member 1 / P61221* / ATP binding cassette subfamily E member 1*  / reaction / complex
 ENSMUSG00000066800 Q05921 / Rnasel / ribonuclease L (2, 5-oligoisoadenylate synthetase-dependent) / Q05823* / ribonuclease L*  / complex






 

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