ENSMUSG00000036333


Mus musculus

Features
Gene ID: ENSMUSG00000036333
  
Biological name :Kidins220
  
Synonyms : Kidins220 / kinase D-interacting substrate 220
  
Possible biological names infered from orthology : Q9ULH0
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: A1.3
Gene start: 24974925
Gene end: 25063152
  
Corresponding Affymetrix probe sets: 10395005 (MoGene1.0st)   1430449_at (Mouse Genome 430 2.0 Array)   1433852_at (Mouse Genome 430 2.0 Array)   1436607_a_at (Mouse Genome 430 2.0 Array)   1455762_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152752
Ensembl peptide - ENSMUSP00000152683
Ensembl peptide - ENSMUSP00000063999
Ensembl peptide - ENSMUSP00000152399
Ensembl peptide - ENSMUSP00000152726
NCBI entrez gene - 77480     See in Manteia.
MGI - MGI:1924730
RefSeq - XM_017315244
RefSeq - XM_006515256
RefSeq - XM_006515257
RefSeq - XM_006515258
RefSeq - XM_006515259
RefSeq - XM_006515260
RefSeq - XM_017315243
RefSeq - NM_001081378
RefSeq - XM_006515249
RefSeq - XM_006515250
RefSeq - XM_006515251
RefSeq - XM_006515252
RefSeq - XM_006515253
RefSeq - XM_006515254
RefSeq - XM_006515255
RefSeq Peptide - NP_001074847
swissprot - E9Q9B7
swissprot - A0A1Y7VNF8
swissprot - A0A1Y7VMH7
swissprot - A0A1Y7VME9
swissprot - A0A1Y7VK25
Ensembl - ENSMUSG00000036333
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kidins220aENSDARG00000031240Danio rerio
 kidins220bENSDARG00000017338Danio rerio
 KIDINS220ENSGALG00000016409Gallus gallus
 Q9ULH0ENSG00000134313Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q99NH0 / Ankrd17 / Ankyrin repeat domain-containing protein 17 / O75179* / ankyrin repeat domain 17*ENSMUSG0000005520417
Ankhd1 / ankyrin repeat and KH domain containing 1 / Q8IWZ3* / ANKHD1-EIF4EBP3* / ANKHD1-EIF4EBP3 readthrough*ENSMUSG0000002448317
Tanc2 / A2A690 / Protein TANC2 / Q9HCD6* / tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2*ENSMUSG0000005358013
Tanc1 / Q0VGY8 / Protein TANC1 / Q9C0D5* / tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1*ENSMUSG0000003516813
Anks6 / Q6GQX6 / Ankyrin repeat and SAM domain-containing protein 6 / Q68DC2* / ankyrin repeat and sterile alpha motif domain containing 6*ENSMUSG000000661919
Q05921 / Rnasel / ribonuclease L (2, 5-oligoisoadenylate synthetase-dependent) / Q05823* / ribonuclease L*ENSMUSG000000668008
Ankrd29 / ankyrin repeat domain 29 / Q8N6D5*ENSMUSG000000577665
Fank1 / Q9DAM9 / Fibronectin type 3 and ankyrin repeat domains 1 protein / Q8TC84* / fibronectin type III and ankyrin repeat domains 1*ENSMUSG000000531114
Ankrd50 / ankyrin repeat domain 50ENSMUSG000000448640


Protein motifs (from Interpro)
Interpro ID Name
 IPR002110  Ankyrin repeat
 IPR011646  KAP family P-loop domain
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR020683  Ankyrin repeat-containing domain
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0038180 nerve growth factor signaling pathway IBA
 biological_processGO:0045859 regulation of protein kinase activity IBA
 biological_processGO:0048813 dendrite morphogenesis IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0019887 protein kinase regulator activity IBA
 molecular_functionGO:0030165 PDZ domain binding IBA


Pathways (from Reactome)
Pathway description
ARMS-mediated activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
Show

Allelic Composition: Col1a1tm1(tetO-EML4/ALK)Kkw/Col1a1+,Tg(Scgb1a1-rtTA)1Jaw/0
Genetic Background: involves: 129 * C57BL/6

 MP:0000939 reduced motor neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Col1a1tm1(tetO-EML4/ALK)Kkw/Col1a1+,Tg(Scgb1a1-rtTA)1Jaw/0
Genetic Background: involves: 129 * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Col1a1tm1(tetO-EML4/ALK)Kkw/Col1a1+,Tg(Scgb1a1-rtTA)1Jaw/0
Genetic Background: involves: 129 * C57BL/6

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Col1a1tm1(tetO-EML4/ALK)Kkw/Col1a1+,Tg(Scgb1a1-rtTA)1Jaw/0
Genetic Background: involves: 129 * C57BL/6

 MP:0003105 abnormal heart atrium morphology "structural anomaly of one or both of the two upper chambers of the heart " [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Col1a1tm1(tetO-EML4/ALK)Kkw/Col1a1+,Tg(Scgb1a1-rtTA)1Jaw/0
Genetic Background: involves: 129 * C57BL/6

 MP:0003140 dilated atria "an expansion in the volume of one or both of the upper chambers of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Col1a1tm1(tetO-EML4/ALK)Kkw/Col1a1+,Tg(Scgb1a1-rtTA)1Jaw/0
Genetic Background: involves: 129 * C57BL/6

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Col1a1tm1(tetO-EML4/ALK)Kkw/Col1a1+,Tg(Scgb1a1-rtTA)1Jaw/0
Genetic Background: involves: 129 * C57BL/6

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col1a1tm1(tetO-EML4/ALK)Kkw/Col1a1+,Tg(Scgb1a1-rtTA)1Jaw/0
Genetic Background: involves: 129 * C57BL/6

 MP:0004950 abnormal brain vasculature "any structural anomaly of the blood vessel network of the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col1a1tm1(tetO-EML4/ALK)Kkw/Col1a1+,Tg(Scgb1a1-rtTA)1Jaw/0
Genetic Background: involves: 129 * C57BL/6

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Col1a1tm1(tetO-EML4/ALK)Kkw/Col1a1+,Tg(Scgb1a1-rtTA)1Jaw/0
Genetic Background: involves: 129 * C57BL/6

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Col1a1tm1(tetO-EML4/ALK)Kkw/Col1a1+,Tg(Scgb1a1-rtTA)1Jaw/0
Genetic Background: involves: 129 * C57BL/6

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atcayji-hes2J/Atcayji-hes2J
Genetic Background: BALB/cJ

Allelic Composition: Kidins220tm1.2Fces/Kidins220tm1.2Fces
Genetic Background: involves: 129 * BALB/c * C57BL/6 * C57BL/6J

 MP:0008762 embryonic lethality "death of an animal in the embryonic period (Mus: up to E14)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atcayji-hes2J/Atcayji-hes2J
Genetic Background: BALB/cJ

 MP:0009936 abnormal dendritic spine morphology "any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atcayji-hes2J/Atcayji-hes2J
Genetic Background: BALB/cJ

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kidins220tm1.2Fces/Kidins220tm1.2Fces
Genetic Background: involves: 129 * BALB/c * C57BL/6 * C57BL/6J

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Kidins220tm1.2Fces/Kidins220tm1.2Fces
Genetic Background: involves: 129 * BALB/c * C57BL/6 * C57BL/6J

 MP:0011380 enlarged brain ventricle "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb]
Show

Allelic Composition: Kidins220tm1.2Fces/Kidins220tm1.2Fces
Genetic Background: involves: 129 * BALB/c * C57BL/6 * C57BL/6J

 MP:0030005 increased retinal apoptosis "increase in the number of cells in the retina undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Kidins220tm1.2Fces/Kidins220tm1.2Fces
Genetic Background: involves: 129 * BALB/c * C57BL/6 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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