ENSMUSG00000066191


Mus musculus

Features
Gene ID: ENSMUSG00000066191
  
Biological name :Anks6
  
Synonyms : Anks6 / Ankyrin repeat and SAM domain-containing protein 6 / Q6GQX6
  
Possible biological names infered from orthology : ankyrin repeat and sterile alpha motif domain containing 6 / Q68DC2
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: B1
Gene start: 47015669
Gene end: 47057427
  
Corresponding Affymetrix probe sets: 10512830 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000155271
Ensembl peptide - ENSMUSP00000081665
Ensembl peptide - ENSMUSP00000103376
NCBI entrez gene - 75691     See in Manteia.
MGI - MGI:1922941
RefSeq - XM_006538337
RefSeq - XM_006538332
RefSeq - XM_006538333
RefSeq - XM_006538334
RefSeq - XM_006538335
RefSeq - XM_006538336
RefSeq - NM_001024136
RefSeq Peptide - NP_001019307
RefSeq Peptide - NP_001343355
swissprot - E9PUD3
swissprot - A2ANT9
swissprot - Q6GQX6
Ensembl - ENSMUSG00000066191
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ANKS6ENSGALG00000013196Gallus gallus
 ANKS6ENSG00000165138Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q99NH0 / Ankrd17 / Ankyrin repeat domain-containing protein 17 / O75179* / ankyrin repeat domain 17*ENSMUSG0000005520424
Ankhd1 / ankyrin repeat and KH domain containing 1 / Q8IWZ3* / ANKHD1-EIF4EBP3* / ANKHD1-EIF4EBP3 readthrough*ENSMUSG0000002448323
Tanc2 / A2A690 / Protein TANC2 / Q9HCD6* / tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2*ENSMUSG0000005358021
Tanc1 / Q0VGY8 / Protein TANC1 / Q9C0D5* / tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1*ENSMUSG0000003516821
Kidins220 / kinase D-interacting substrate 220 / Q9ULH0*ENSMUSG0000003633319
Q05921 / Rnasel / ribonuclease L (2, 5-oligoisoadenylate synthetase-dependent) / Q05823* / ribonuclease L*ENSMUSG0000006680014
Ankrd29 / ankyrin repeat domain 29 / Q8N6D5*ENSMUSG0000005776611
Fank1 / Q9DAM9 / Fibronectin type 3 and ankyrin repeat domains 1 protein / Q8TC84* / fibronectin type III and ankyrin repeat domains 1*ENSMUSG000000531118
Ankrd50 / ankyrin repeat domain 50ENSMUSG000000448640


Protein motifs (from Interpro)
Interpro ID Name
 IPR001660  Sterile alpha motif domain
 IPR002110  Ankyrin repeat
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR020683  Ankyrin repeat-containing domain
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007368 determination of left/right symmetry IMP
 biological_processGO:0007507 heart development IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000273 overriding aorta "congenitally mispositioned aorta where the origin straddles the ventral septum and so receives ejected blood from the right ventricle as well as the left." [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:67826]
Show

Allelic Composition: Foxn1nu-2J/Foxn1nu-2J
Genetic Background: B6(SJL)-Foxn1nu-2J/GrsrJ

 MP:0000282 abnormal atrial septum morphology "abnormality in the wall between the atria of the heart, usually incomplete closure " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Ankrd11tm1b(EUCOMM)Wtsi/Ankrd11+
Genetic Background: C57BL/6N-Ankrd11tm1b(EUCOMM)Wtsi/Ics

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Foxn1nu-2J/Foxn1nu-2J
Genetic Background: B6(SJL)-Foxn1nu-2J/GrsrJ

 MP:0000644 dextrocardia "cardiac apex pointing to the right as opposed to the normal levocardia" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxn1nu-2J/Foxn1nu-2J
Genetic Background: B6(SJL)-Foxn1nu-2J/GrsrJ

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
Show

Allelic Composition: Ankrd11tm1b(EUCOMM)Wtsi/Ankrd11+
Genetic Background: C57BL/6N-Ankrd11tm1b(EUCOMM)Wtsi/Ics

 MP:0002747 abnormal aortic valve morphology "malformation of the valve between the left ventricle and the ascending aorta" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ankrd11tm1b(EUCOMM)Wtsi/Ankrd11+
Genetic Background: C57BL/6N-Ankrd11tm1b(EUCOMM)Wtsi/Ics

 MP:0003826 abnormal Mullerian duct morphology "malformation of the transient embryonic tubes that empty into the cloaca and in the female develop into the oviducts, uterus, and vagina" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ankrd11tm1b(EUCOMM)Wtsi/Ankrd11+
Genetic Background: C57BL/6N-Ankrd11tm1b(EUCOMM)Wtsi/Ics

 MP:0003827 abnormal Wolffian duct morphology "malformation of the transient embryonic tubes that empty into the cloca and degenerate in the male " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ankrd11tm1b(EUCOMM)Wtsi/Ankrd11+
Genetic Background: C57BL/6N-Ankrd11tm1b(EUCOMM)Wtsi/Ics

 MP:0004110 transposition of great arteries "cardiovascular malformation in which the aorta arises from the right ventricle while the pulmonary artery arises from the left ventricle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ankrd11tm1b(EUCOMM)Wtsi/Ankrd11+
Genetic Background: C57BL/6N-Ankrd11tm1b(EUCOMM)Wtsi/Ics

 MP:0004133 heterotaxia "abnormal arrangement of organs or parts of the body in relation to each other" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxn1nu-2J/Foxn1nu-2J
Genetic Background: B6(SJL)-Foxn1nu-2J/GrsrJ

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ankrd11tm1b(EUCOMM)Wtsi/Ankrd11+
Genetic Background: C57BL/6N-Ankrd11tm1b(EUCOMM)Wtsi/Ics

 MP:0006061 right atrial isomerism "altered asymmetric patterning of the atria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxn1nu-2J/Foxn1nu-2J
Genetic Background: B6(SJL)-Foxn1nu-2J/GrsrJ

 MP:0006063 abnormal inferior vena cava morphology "structural malformation in the principal vein draining blood from the lower portion of the body" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]
Show

Allelic Composition: Foxn1nu-2J/Foxn1nu-2J
Genetic Background: B6(SJL)-Foxn1nu-2J/GrsrJ

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
Show

Allelic Composition: Foxn1nu-2J/Foxn1nu-2J
Genetic Background: B6(SJL)-Foxn1nu-2J/GrsrJ

 MP:0010406 absent atrial septum "absence of the thin membranous structure between the two heart atria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ankrd11tm1b(EUCOMM)Wtsi/Ankrd11+
Genetic Background: C57BL/6N-Ankrd11tm1b(EUCOMM)Wtsi/Ics

 MP:0010412 atrioventricular septal defect "defects in the thin membranous structure between the right atrium and left ventricle that arise from faulty development of the embryonic endocardial cushions; the spectrum ranges from a primum atrial septal defect and cleft mitral valve, known as a partial atrioventricular septal defect (partial AVSD), to defects of both the primum atrial septum and inlet ventricular septum and the presence of a common atrioventricular valve, referred to as complete atrioventricular septal defect (complete AVSD)" [http://emedicine.medscape.com]
Show

Allelic Composition: Foxn1nu-2J/Foxn1nu-2J
Genetic Background: B6(SJL)-Foxn1nu-2J/GrsrJ

 MP:0010418 perimembraneous ventricular septal defect "abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect" [http://emedicine.medscape.com]
Show

Allelic Composition: Foxn1nu-2J/Foxn1nu-2J
Genetic Background: B6(SJL)-Foxn1nu-2J/GrsrJ

Allelic Composition: Anks6tm1b(KOMP)Wtsi/Anks6tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Anks6tm1b(KOMP)Wtsi/Wtsi

 MP:0010440 anomalous pulmonary venous connection "abnormal development and attachment of the four pulmonary veins that normally attach to the left atrium of the heart, resulting in either partial or complete anomalous drainage back into the systemic venous circulation via an anomalous connection to the right atrium, the superior or inferior vena cava, the innominate vein, the coronary sinus or the left subclavian artery" [http://emedicine.medscape.com]
Show

Allelic Composition: Anks6tm1b(KOMP)Wtsi/Anks6tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Anks6tm1b(KOMP)Wtsi/Wtsi

 MP:0010607 common atrioventricular valve "the presence of a single atrioventricular valve instead of both a mitral and tricuspid valve, most commonly due to incomplete or failure of fetal atrioventricular canal septation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Anks6tm1b(KOMP)Wtsi/Anks6tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Anks6tm1b(KOMP)Wtsi/Wtsi

 MP:0010854 lung situs inversus "anomaly in the asymmetry of the lung such that lung lobes on both the left and right side have the morphology normally seen on the opposite side of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Anks6tm1b(KOMP)Wtsi/Anks6tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Anks6tm1b(KOMP)Wtsi/Wtsi

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Anks6tm1b(KOMP)Wtsi/Anks6tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Anks6tm1b(KOMP)Wtsi/Wtsi

 MP:0011249 abdominal situs inversus "lateral transposition or mirroring of the viscera of the abdomen, sometimes incomplete, with all organs maintaining the normal relative position with respect to each other" [MGI:csmith]
Show

Allelic Composition: Anks6tm1b(KOMP)Wtsi/Anks6tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Anks6tm1b(KOMP)Wtsi/Wtsi

 MP:0011683 dual inferior vena cava "presence of two inferior vena cavae, often resulting from the persistence of both supracardinal veins during development; the two structures may be symmetric or asymmetric but typically join together at the renal vein" [MGI:csmith, PMID:10835118]
Show

Allelic Composition: Foxn1nu-2J/Foxn1nu-2J
Genetic Background: B6(SJL)-Foxn1nu-2J/GrsrJ

Allelic Composition: Anks6tm1b(KOMP)Wtsi/Anks6tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Anks6tm1b(KOMP)Wtsi/Wtsi

 MP:0013294 prenatal lethality prior to heart atrial septation "death prior to the completion of heart atrial septation (Mus: E14.5-15.5)" [MGI:smb]
Show

Allelic Composition: Anks6tm1b(KOMP)Wtsi/Anks6tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Anks6tm1b(KOMP)Wtsi/Wtsi

 MP:0013876 absent ductus venosus valve "absence of the valve present on the right side of the ductus venosus at the site of the junction with the inferior vena cava" [PMID:5438957]
Show

Allelic Composition: Anks6tm1b(KOMP)Wtsi/Anks6tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Anks6tm1b(KOMP)Wtsi/Wtsi

 MP:0013975 abnormal coronary sinus connection 
Show

Allelic Composition: Anks6tm1b(KOMP)Wtsi/Anks6tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Anks6tm1b(KOMP)Wtsi/Wtsi

 MP:0013977 symmetric azygos veins 
Show

Allelic Composition: Anks6tm1b(KOMP)Wtsi/Anks6tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Anks6tm1b(KOMP)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr