ENSG00000137877


Homo sapiens

Features
Gene ID: ENSG00000137877
  
Biological name :SPTBN5
  
Synonyms : Q9NRC6 / spectrin beta, non-erythrocytic 5 / SPTBN5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: -1
Band: q15.1
Gene start: 41848144
Gene end: 41894077
  
Corresponding Affymetrix probe sets: 220067_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000317790
NCBI entrez gene - 51332     See in Manteia.
OMIM - 605916
RefSeq - XM_017022303
RefSeq - NM_016642
RefSeq - XM_017022301
RefSeq - XM_017022302
RefSeq - XM_017022299
RefSeq - XM_017022300
RefSeq Peptide - NP_057726
swissprot - Q9NRC6
Ensembl - ENSG00000137877
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sptbn5ENSDARG00000097683Danio rerio
 SPTBN5ENSGALG00000008940Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O15020 / SPTBN2 / spectrin beta, non-erythrocytic 2ENSG0000017389819
Q9H254 / SPTBN4 / spectrin beta, non-erythrocytic 4ENSG0000016046019
Q01082 / SPTBN1 / spectrin beta, non-erythrocytic 1ENSG0000011530618
SPTB / P11277 / spectrin beta, erythrocyticENSG0000007018217
Q13813 / SPTAN1 / spectrin alpha, non-erythrocytic 1ENSG0000019769413
SPTA1 / P02549 / spectrin alpha, erythrocytic 1ENSG0000016355412
ACTN1 / P12814 / actinin alpha 1ENSG000000721108
ACTN4 / O43707 / actinin alpha 4ENSG000001304028
ACTN2 / P35609 / actinin alpha 2ENSG000000775228
ACTN3 / Q08043 / actinin alpha 3 (gene/pseudogene)ENSG000002487468


Protein motifs (from Interpro)
Interpro ID Name
 IPR001589  Actinin-type actin-binding domain, conserved site
 IPR001715  Calponin homology domain
 IPR001849  Pleckstrin homology domain
 IPR002017  Spectrin repeat
 IPR011993  PH-like domain superfamily
 IPR018159  Spectrin/alpha-actinin
 IPR036872  CH domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport TAS
 biological_processGO:0007030 Golgi organization IMP
 biological_processGO:0007041 lysosomal transport IMP
 biological_processGO:0007411 axon guidance TAS
 biological_processGO:0030036 actin cytoskeleton organization NAS
 biological_processGO:0051260 protein homooligomerization IDA
 biological_processGO:0051693 actin filament capping IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0008091 spectrin NAS
 cellular_componentGO:0016020 membrane NAS
 cellular_componentGO:0032391 photoreceptor connecting cilium IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0097381 photoreceptor disc membrane IDA
 molecular_functionGO:0003779 actin binding NAS
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0019894 kinesin binding IDA
 molecular_functionGO:0030507 spectrin binding IDA
 molecular_functionGO:0032029 myosin tail binding IDA
 molecular_functionGO:0034452 dynactin binding IDA
 molecular_functionGO:0043621 protein self-association IDA
 molecular_functionGO:0045505 dynein intermediate chain binding IDA


Pathways (from Reactome)
Pathway description
NCAM signaling for neurite out-growth
Interaction between L1 and Ankyrins
RAF/MAP kinase cascade
COPI-mediated anterograde transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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