ENSG00000138496


Homo sapiens

Features
Gene ID: ENSG00000138496
  
Biological name :PARP9
  
Synonyms : PARP9 / poly(ADP-ribose) polymerase family member 9 / Q8IXQ6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: q21.1
Gene start: 122527924
Gene end: 122564577
  
Corresponding Affymetrix probe sets: 223220_s_at (Human Genome U133 Plus 2.0 Array)   227807_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000419506
Ensembl peptide - ENSP00000419001
Ensembl peptide - ENSP00000419626
Ensembl peptide - ENSP00000353512
Ensembl peptide - ENSP00000417664
Ensembl peptide - ENSP00000418894
NCBI entrez gene - 83666     See in Manteia.
OMIM - 612065
RefSeq - XM_017007306
RefSeq - NM_001146103
RefSeq - NM_001146104
RefSeq - NM_001146105
RefSeq - NM_001146106
RefSeq - NM_031458
RefSeq - XM_005247820
RefSeq - XM_011513218
RefSeq - XM_017007304
RefSeq - XM_017007305
RefSeq - NM_001146102
RefSeq Peptide - NP_001139575
RefSeq Peptide - NP_001139576
RefSeq Peptide - NP_001139577
RefSeq Peptide - NP_001139578
RefSeq Peptide - NP_113646
RefSeq Peptide - NP_001139574
swissprot - C9K0E5
swissprot - G5E9U8
swissprot - Q8IXQ6
Ensembl - ENSG00000138496
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch211-219a4.6ENSDARG00000006848Danio rerio
 PARP9ENSGALG00000045511Gallus gallus
 Parp9ENSMUSG00000022906Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PARP14 / Q460N5 / poly(ADP-ribose) polymerase family member 14ENSG0000017319328
PARP10 / Q53GL7 / poly(ADP-ribose) polymerase family member 10ENSG0000017868515
PARP15 / Q460N3 / poly(ADP-ribose) polymerase family member 15ENSG0000017320013
Q7Z2W4 / ZC3HAV1 / zinc finger CCCH-type containing, antiviral 1ENSG0000010593911
PARP12 / Q9H0J9 / poly(ADP-ribose) polymerase family member 12ENSG0000005937810
Q7Z3E1 / TIPARP / TCDD inducible poly(ADP-ribose) polymeraseENSG000001636599
PARP11 / Q9NR21 / poly(ADP-ribose) polymerase family member 11ENSG000001112246


Protein motifs (from Interpro)
Interpro ID Name
 IPR002589  Macro domain
 IPR012317  Poly(ADP-ribose) polymerase, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0002230 positive regulation of defense response to virus by host IGI
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006302 double-strand break repair IMP
 biological_processGO:0006471 protein ADP-ribosylation IDA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0010608 posttranscriptional regulation of gene expression IMP
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0016477 cell migration TAS
 biological_processGO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway TAS
 biological_processGO:0035563 positive regulation of chromatin binding IGI
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IMP
 biological_processGO:0043086 negative regulation of catalytic activity IDA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IGI
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0060330 regulation of response to interferon-gamma IDA
 biological_processGO:0060335 positive regulation of interferon-gamma-mediated signaling pathway IMP
 biological_processGO:1900182 positive regulation of protein localization to nucleus IGI
 biological_processGO:2001034 positive regulation of double-strand break repair via nonhomologous end joining IMP
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0090734 site of DNA damage IDA
 molecular_functionGO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding IMP
 molecular_functionGO:0003950 NAD+ ADP-ribosyltransferase activity TAS
 molecular_functionGO:0004857 enzyme inhibitor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0042393 histone binding IPI
 molecular_functionGO:0044389 ubiquitin-like protein ligase binding IPI
 molecular_functionGO:0072570 ADP-D-ribose binding IMP
 molecular_functionGO:0097677 STAT family protein binding IPI


Pathways (from Reactome)
Pathway description
Nicotinamide salvaging


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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