ENSG00000178685


Homo sapiens

Features
Gene ID: ENSG00000178685
  
Biological name :PARP10
  
Synonyms : PARP10 / poly(ADP-ribose) polymerase family member 10 / Q53GL7
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: q24.3
Gene start: 143977153
Gene end: 144012772
  
Corresponding Affymetrix probe sets: 226401_at (Human Genome U133 Plus 2.0 Array)   228669_x_at (Human Genome U133 Plus 2.0 Array)   229350_x_at (Human Genome U133 Plus 2.0 Array)   238083_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000325618
Ensembl peptide - ENSP00000431250
Ensembl peptide - ENSP00000436697
Ensembl peptide - ENSP00000436333
Ensembl peptide - ENSP00000436301
Ensembl peptide - ENSP00000435793
Ensembl peptide - ENSP00000435161
Ensembl peptide - ENSP00000434776
Ensembl peptide - ENSP00000434411
Ensembl peptide - ENSP00000434005
Ensembl peptide - ENSP00000433990
Ensembl peptide - ENSP00000432733
Ensembl peptide - ENSP00000432204
Ensembl peptide - ENSP00000431818
Ensembl peptide - ENSP00000431620
Ensembl peptide - ENSP00000314320
NCBI entrez gene - 84875     See in Manteia.
OMIM - 609564
RefSeq - NM_032789
RefSeq - NM_001317895
RefSeq - XM_011517336
RefSeq Peptide - NP_001304824
RefSeq Peptide - NP_116178
swissprot - E9PPE7
swissprot - E9PNI7
swissprot - E9PM86
swissprot - E9PLE8
swissprot - E9PK67
swissprot - E9PSG8
swissprot - E9PIK9
swissprot - E9PIA6
swissprot - F8W8G7
swissprot - Q53GL7
swissprot - E9PJI2
swissprot - E9PSE7
swissprot - E9PQQ6
swissprot - E9PPV8
swissprot - E9PPU2
Ensembl - ENSG00000178685
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch1073-296d18.1ENSDARG00000087145Danio rerio
 Parp10ENSMUSG00000063268Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PARP14 / Q460N5 / poly(ADP-ribose) polymerase family member 14ENSG0000017319318
PARP9 / Q8IXQ6 / poly(ADP-ribose) polymerase family member 9ENSG0000013849613
PARP12 / Q9H0J9 / poly(ADP-ribose) polymerase family member 12ENSG0000005937812
PARP15 / Q460N3 / poly(ADP-ribose) polymerase family member 15ENSG0000017320010
Q7Z2W4 / ZC3HAV1 / zinc finger CCCH-type containing, antiviral 1ENSG0000010593910
Q7Z3E1 / TIPARP / TCDD inducible poly(ADP-ribose) polymeraseENSG000001636599
PARP11 / Q9NR21 / poly(ADP-ribose) polymerase family member 11ENSG000001112247


Protein motifs (from Interpro)
Interpro ID Name
 IPR012317  Poly(ADP-ribose) polymerase, catalytic domain
 IPR034464  PARP-10, RNA recognition motif 1 and 2
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006471 protein ADP-ribosylation IMP
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0010847 regulation of chromatin assembly IDA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IMP
 biological_processGO:0033159 negative regulation of protein import into nucleus, translocation IMP
 biological_processGO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway TAS
 biological_processGO:0045071 negative regulation of viral genome replication IMP
 biological_processGO:0048147 negative regulation of fibroblast proliferation IDA
 biological_processGO:0070212 protein poly-ADP-ribosylation IMP
 biological_processGO:0070213 protein auto-ADP-ribosylation IMP
 biological_processGO:1900045 negative regulation of protein K63-linked ubiquitination IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003950 NAD+ ADP-ribosyltransferase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:0070530 K63-linked polyubiquitin modification-dependent protein binding IMP


Pathways (from Reactome)
Pathway description
Nicotinamide salvaging


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr