ENSMUSG00000063268


Mus musculus

Features
Gene ID: ENSMUSG00000063268
  
Biological name :Parp10
  
Synonyms : Parp10 / poly (ADP-ribose) polymerase family, member 10
  
Possible biological names infered from orthology : Q53GL7
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: D3
Gene start: 76231174
Gene end: 76243441
  
Corresponding Affymetrix probe sets: 10429843 (MoGene1.0st)   1452178_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000075110
Ensembl peptide - ENSMUSP00000129765
Ensembl peptide - ENSMUSP00000131370
NCBI entrez gene - 671535     See in Manteia.
MGI - MGI:3712326
RefSeq - NM_001163575
RefSeq - NM_001163576
RefSeq Peptide - NP_001157047
RefSeq Peptide - NP_001157048
swissprot - F6Z9X8
swissprot - Q8CIE4
Ensembl - ENSMUSG00000063268
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch1073-296d18.1ENSDARG00000087145Danio rerio
 PARP10ENSG00000178685Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Parp14 / Q2EMV9 / Poly [ADP-ribose] polymerase 14 / Q460N5* / poly(ADP-ribose) polymerase family member 14*ENSMUSG0000003442217
Parp9 / Q8CAS9 / Poly [ADP-ribose] polymerase 9 / Q8IXQ6* / poly(ADP-ribose) polymerase family member 9*ENSMUSG0000002290612
Parp12 / Q8BZ20 / Poly [ADP-ribose] polymerase 12 / Q9H0J9* / poly(ADP-ribose) polymerase family member 12*ENSMUSG0000003850711
Q8C1B2 / Tiparp / TCDD-inducible poly(ADP-ribose) polymerase / Q7Z3E1*ENSMUSG0000003464010
Q3UPF5 / Zc3hav1 / zinc finger CCCH type, antiviral 1 / Q7Z2W4* / zinc finger CCCH-type containing, antiviral 1*ENSMUSG000000298268
Parp11 / Q8CFF0 / Mus musculus poly (ADP-ribose) polymerase family, member 11 (Parp11), transcript variant 3, mRNA. / Q9NR21* / poly(ADP-ribose) polymerase family member 11*ENSMUSG000000379977


Protein motifs (from Interpro)
Interpro ID Name
 IPR012317  Poly(ADP-ribose) polymerase, catalytic domain
 IPR034464  PARP-10, RNA recognition motif 1 and 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006471 protein ADP-ribosylation ISO
 biological_processGO:0010629 negative regulation of gene expression ISO
 biological_processGO:0010847 regulation of chromatin assembly ISO
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity ISO
 biological_processGO:0033159 negative regulation of protein import into nucleus, translocation ISO
 biological_processGO:0045071 negative regulation of viral genome replication ISO
 biological_processGO:0048147 negative regulation of fibroblast proliferation ISO
 biological_processGO:0070212 protein poly-ADP-ribosylation ISO
 biological_processGO:0070213 protein auto-ADP-ribosylation ISO
 biological_processGO:1900045 negative regulation of protein K63-linked ubiquitination ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005730 nucleolus ISO
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 molecular_functionGO:0003950 NAD+ ADP-ribosyltransferase activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:0070530 K63-linked polyubiquitin modification-dependent protein binding ISO


Pathways (from Reactome)
Pathway description
Nicotinamide salvaging


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cd79atm2(cre/Esr1*)Reth/Cd79a+,Rag1tm1.1Sadu/Rag1tm1.1Sadu
Genetic Background: involves: BALB/c

 MP:0008814 reduced nerve conduction velocity "decrease in the rate at which an eletrical impulse travels through a nerve" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd79atm2(cre/Esr1*)Reth/Cd79a+,Rag1tm1.1Sadu/Rag1tm1.1Sadu
Genetic Background: involves: BALB/c

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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