ENSMUSG00000034640


Mus musculus

Features
Gene ID: ENSMUSG00000034640
  
Biological name :Tiparp
  
Synonyms : Q8C1B2 / TCDD-inducible poly(ADP-ribose) polymerase / Tiparp
  
Possible biological names infered from orthology : Q7Z3E1
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: E1
Gene start: 65528410
Gene end: 65555518
  
Corresponding Affymetrix probe sets: 10492428 (MoGene1.0st)   1426721_s_at (Mouse Genome 430 2.0 Array)   1452160_at (Mouse Genome 430 2.0 Array)   1452161_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000119951
Ensembl peptide - ENSMUSP00000048051
NCBI entrez gene - 99929     See in Manteia.
MGI - MGI:2159210
RefSeq - NM_178892
RefSeq Peptide - NP_849223
swissprot - D3Z7U2
swissprot - Q8C1B2
Ensembl - ENSMUSG00000034640
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TIPARPENSGALG00000010256Gallus gallus
 Q7Z3E1ENSG00000163659Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Parp12 / Q8BZ20 / Poly [ADP-ribose] polymerase 12 / Q9H0J9* / poly(ADP-ribose) polymerase family member 12*ENSMUSG0000003850725
Q3UPF5 / Zc3hav1 / zinc finger CCCH type, antiviral 1 / Q7Z2W4* / zinc finger CCCH-type containing, antiviral 1*ENSMUSG0000002982620
Parp14 / Q2EMV9 / Poly [ADP-ribose] polymerase 14 / Q460N5* / poly(ADP-ribose) polymerase family member 14*ENSMUSG0000003442218
Parp10 / poly (ADP-ribose) polymerase family, member 10 / Q53GL7*ENSMUSG0000006326815
Parp11 / Q8CFF0 / Mus musculus poly (ADP-ribose) polymerase family, member 11 (Parp11), transcript variant 3, mRNA. / Q9NR21* / poly(ADP-ribose) polymerase family member 11*ENSMUSG0000003799714
Parp9 / Q8CAS9 / Poly [ADP-ribose] polymerase 9 / Q8IXQ6* / poly(ADP-ribose) polymerase family member 9*ENSMUSG0000002290612


Protein motifs (from Interpro)
Interpro ID Name
 IPR000571  Zinc finger, CCCH-type
 IPR004170  WWE domain
 IPR012317  Poly(ADP-ribose) polymerase, catalytic domain
 IPR036855  Zinc finger, CCCH-type superfamily
 IPR037197  WWE domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001570 vasculogenesis IMP
 biological_processGO:0001822 kidney development IMP
 biological_processGO:0006471 protein ADP-ribosylation IDA
 biological_processGO:0006807 nitrogen compound metabolic process IMP
 biological_processGO:0008209 androgen metabolic process IMP
 biological_processGO:0008210 estrogen metabolic process IMP
 biological_processGO:0008585 female gonad development IMP
 biological_processGO:0009791 post-embryonic development IMP
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0030097 hemopoiesis IMP
 biological_processGO:0045732 positive regulation of protein catabolic process IEA
 biological_processGO:0048008 platelet-derived growth factor receptor signaling pathway IMP
 biological_processGO:0048705 skeletal system morphogenesis IMP
 biological_processGO:0048745 smooth muscle tissue development IMP
 biological_processGO:0060021 roof of mouth development IMP
 biological_processGO:0060325 face morphogenesis IMP
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003950 NAD+ ADP-ribosyltransferase activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:0035326 enhancer binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000074 abnormal neurocranium morphology "malformed bones of the skull enclosing the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
Show

Allelic Composition: Arid5bGt(ROSA)75Sor/Arid5bGt(ROSA)75Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0000091 short premaxilla "reduced length of the anterior and interior portion of the maxilla" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Arid5bGt(ROSA)75Sor/Arid5bGt(ROSA)75Sor
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Pdgfratm2Sor/Pdgfra+,TiparpGt(ROSA)79Sor/TiparpGt(ROSA)79Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0000097 short maxilla "reduced length of the upper jaw bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Arid5bGt(ROSA)75Sor/Arid5bGt(ROSA)75Sor
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Pdgfratm2Sor/Pdgfra+,TiparpGt(ROSA)79Sor/TiparpGt(ROSA)79Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0000107 abnormal frontal bone morphology "malformed bone forming the forehead and part of the eye orbit" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]
Show

Allelic Composition: Arid5bGt(ROSA)75Sor/Arid5bGt(ROSA)75Sor
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Pdgfratm2Sor/Pdgfra+,TiparpGt(ROSA)79Sor/TiparpGt(ROSA)79Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0000157 abnormal sternum morphology "malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]
Show

Allelic Composition: Arid5bGt(ROSA)75Sor/Arid5bGt(ROSA)75Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Arid5bGt(ROSA)75Sor/Arid5bGt(ROSA)75Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
Show

Allelic Composition: Arid5bGt(ROSA)75Sor/Arid5bGt(ROSA)75Sor
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Pdgfratm2Sor/Pdgfra+,TiparpGt(ROSA)79Sor/TiparpGt(ROSA)79Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0000767 abnormal smooth muscle morphology "anomalous structure of any of the unstriated muscle fibers of the internal organs, blood vessels, hair follicles, etc. " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Arid5bGt(ROSA)75Sor/Arid5bGt(ROSA)75Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Arid5bGt(ROSA)75Sor/Arid5bGt(ROSA)75Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Arid5bGt(ROSA)75Sor/Arid5bGt(ROSA)75Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001859 kidney inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Arid5bGt(ROSA)75Sor/Arid5bGt(ROSA)75Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Arid5bGt(ROSA)75Sor/Arid5bGt(ROSA)75Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Pdgfrbtm1Sor/Pdgfrb+,Plekha1Gt(ROSA)82Sor/Plekha1Gt(ROSA)82Sor
Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Pdgfrbtm1Sor/Pdgfrb+,Plekha1Gt(ROSA)82Sor/Plekha1Gt(ROSA)82Sor
Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)

Allelic Composition: Pdgfrbtm1Sor/Pdgfrb+,TiparpGt(ROSA)79Sor/TiparpGt(ROSA)79Sor
Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pdgfrbtm1Sor/Pdgfrb+,Plekha1Gt(ROSA)82Sor/Plekha1Gt(ROSA)82Sor
Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)

 MP:0002016 ovarian cysts "cystic ovary; usually refers to a benign growth" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Pdgfrbtm1Sor/Pdgfrb+,Plekha1Gt(ROSA)82Sor/Plekha1Gt(ROSA)82Sor
Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Arid5bGt(ROSA)75Sor/Arid5bGt(ROSA)75Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Arid5bGt(ROSA)75Sor/Arid5bGt(ROSA)75Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002293 long gestation period "increase in the average duration of a pregnancy " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pdgfrbtm1Sor/Pdgfrb+,Plekha1Gt(ROSA)82Sor/Plekha1Gt(ROSA)82Sor
Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Arid5bGt(ROSA)75Sor/Arid5bGt(ROSA)75Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002681 increased number of corpora lutea "greater than normal numbers of yellow endocrine body formed in the ovary after follicle rupture in a given oestrus cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pdgfrbtm1Sor/Pdgfrb+,Plekha1Gt(ROSA)82Sor/Plekha1Gt(ROSA)82Sor
Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Arid5bGt(ROSA)75Sor/Arid5bGt(ROSA)75Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Arid5bGt(ROSA)75Sor/Arid5bGt(ROSA)75Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Arid5bGt(ROSA)75Sor/Arid5bGt(ROSA)75Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0003755 abnormal palate "anomaly in the roof of the mouth in vertebrates formed anteriorly by a bony projection of the upper jaw (hard palate) and posteriorly by the fold of connective tissue (soft palate) " [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Arid5bGt(ROSA)75Sor/Arid5bGt(ROSA)75Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0004471 short nasal bone "reduced length of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Arid5bGt(ROSA)75Sor/Arid5bGt(ROSA)75Sor
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Pdgfratm2Sor/Pdgfra+,TiparpGt(ROSA)79Sor/TiparpGt(ROSA)79Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0004832 enlarged ovary "increased size of the female reproductive gland containing the germ cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pdgfrbtm1Sor/Pdgfrb+,Plekha1Gt(ROSA)82Sor/Plekha1Gt(ROSA)82Sor
Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)

 MP:0004906 enlarged uterus 
Show

Allelic Composition: Pdgfrbtm1Sor/Pdgfrb+,Plekha1Gt(ROSA)82Sor/Plekha1Gt(ROSA)82Sor
Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)

 MP:0004969 pale kidney "kidney lacks normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Arid5bGt(ROSA)75Sor/Arid5bGt(ROSA)75Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0005097 polychromatophilia "condition characterized by the presence of red blood cells that have an affinity for acid, basic, and neutral stains" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:305]
Show

Allelic Composition: Arid5bGt(ROSA)75Sor/Arid5bGt(ROSA)75Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0005181 decreased circulating estradiol level "less than the normal blood concentration of this most potent naturally occurring estrogen in mammals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pdgfrbtm1Sor/Pdgfrb+,Plekha1Gt(ROSA)82Sor/Plekha1Gt(ROSA)82Sor
Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Arid5bGt(ROSA)75Sor/Arid5bGt(ROSA)75Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Arid5bGt(ROSA)75Sor/Arid5bGt(ROSA)75Sor
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Pdgfratm2Sor/Pdgfra+,TiparpGt(ROSA)79Sor/TiparpGt(ROSA)79Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Arid5bGt(ROSA)75Sor/Arid5bGt(ROSA)75Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0008146 asymmetric rib-sternum attachment "loss of bilateral symmetry in rib attachments to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Arid5bGt(ROSA)75Sor/Arid5bGt(ROSA)75Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0009006 prolonged estrous cycle "increase in the length of the sexual cycle of female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pdgfrbtm1Sor/Pdgfrb+,Plekha1Gt(ROSA)82Sor/Plekha1Gt(ROSA)82Sor
Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)

 MP:0009895 decreased palatine shelf size "reduced size of the bony projection of the palatine bone that normally fuses with maxillary shelf to form secondary (hard) palate" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Arid5bGt(ROSA)75Sor/Arid5bGt(ROSA)75Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0011128 increased secondary ovarian follicle number "greater than normal numbers of the ovarian follicle in which the primary oocyte attains its full size and is surrounded by an extracellular glycoprotein layer (zona pellucida) that separates it from a peripheral layer of follicular cells permeated by one or more fluid-filled antra; the primary oocyte occupies the cumulus oophorus while the theca of the follicle develops into internal and external layers" [MGI:csmith]
Show

Allelic Composition: Pdgfrbtm1Sor/Pdgfrb+,Plekha1Gt(ROSA)82Sor/Plekha1Gt(ROSA)82Sor
Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)

 MP:0030189 broad snout "increased width of the anterior facial part of the face or muzzle containing the oral and nasal regions" [MGI:anna]
Show

Allelic Composition: Arid5bGt(ROSA)75Sor/Arid5bGt(ROSA)75Sor
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Pdgfratm2Sor/Pdgfra+,TiparpGt(ROSA)79Sor/TiparpGt(ROSA)79Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0030383 small presphenoid bone "reduced size of the anterior part of the body of the sphenoid bone in front of the basisphenoid; it is usually a separate bone in the young or fetus, but becomes a part of the sphenoid in the adult" [MGI:anna]
Show

Allelic Composition: Arid5bGt(ROSA)75Sor/Arid5bGt(ROSA)75Sor
Genetic Background: involves: 129S4/SvJaeSor

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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