ENSMUSG00000034422


Mus musculus

Features
Gene ID: ENSMUSG00000034422
  
Biological name :Parp14
  
Synonyms : Parp14 / Poly [ADP-ribose] polymerase 14 / Q2EMV9
  
Possible biological names infered from orthology : poly(ADP-ribose) polymerase family member 14 / Q460N5
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: B3
Gene start: 35832874
Gene end: 35871544
  
Corresponding Affymetrix probe sets: 10439249 (MoGene1.0st)   1432548_at (Mouse Genome 430 2.0 Array)   1451564_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000037657
NCBI entrez gene - 547253     See in Manteia.
MGI - MGI:1919489
RefSeq - XM_006522394
RefSeq - NM_001039530
RefSeq - XM_006522392
RefSeq - XM_006522393
RefSeq Peptide - NP_001034619
swissprot - Q2EMV9
Ensembl - ENSMUSG00000034422
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch211-219a4.3ENSDARG00000040445Danio rerio
 ENSGALG00000026422Gallus gallus
 ENSGALG00000012072Gallus gallus
 PARP14ENSG00000173193Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Parp9 / Q8CAS9 / Poly [ADP-ribose] polymerase 9 / Q8IXQ6* / poly(ADP-ribose) polymerase family member 9*ENSMUSG0000002290611
Parp10 / poly (ADP-ribose) polymerase family, member 10 / Q53GL7*ENSMUSG000000632689
Q3UPF5 / Zc3hav1 / zinc finger CCCH type, antiviral 1 / Q7Z2W4* / zinc finger CCCH-type containing, antiviral 1*ENSMUSG000000298268
Parp12 / Q8BZ20 / Poly [ADP-ribose] polymerase 12 / Q9H0J9* / poly(ADP-ribose) polymerase family member 12*ENSMUSG000000385078
Q8C1B2 / Tiparp / TCDD-inducible poly(ADP-ribose) polymerase / Q7Z3E1*ENSMUSG000000346406
Parp11 / Q8CFF0 / Mus musculus poly (ADP-ribose) polymerase family, member 11 (Parp11), transcript variant 3, mRNA. / Q9NR21* / poly(ADP-ribose) polymerase family member 11*ENSMUSG000000379975


Protein motifs (from Interpro)
Interpro ID Name
 IPR002589  Macro domain
 IPR004170  WWE domain
 IPR012317  Poly(ADP-ribose) polymerase, catalytic domain
 IPR034517  PARP-14, RNA recognition motif 2
 IPR036612  K Homology domain, type 1 superfamily
 IPR037197  WWE domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006471 protein ADP-ribosylation IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0042532 negative regulation of tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0060336 negative regulation of interferon-gamma-mediated signaling pathway IEA
 biological_processGO:0070212 protein poly-ADP-ribosylation ISO
 biological_processGO:1902216 positive regulation of interleukin-4-mediated signaling pathway IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003950 NAD+ ADP-ribosyltransferase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0070403 NAD+ binding ISO


Pathways (from Reactome)
Pathway description
Nicotinamide salvaging


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001807 decreased IgA "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col1a1tm1(tetO-Fos)Wag/Col1a1+,Rag1tm1Mom/Rag1tm1Mom,Tg(KRT5-rtTA)T2D6Sgkd/0
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0002007 increased sensitivity to gamma-irradiation "increased incidence of cell death following high levels of gamma-irradiation" [J:51834]
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Allelic Composition: Col1a1tm1(tetO-Fos)Wag/Col1a1+,Rag1tm1Mom/Rag1tm1Mom,Tg(KRT5-rtTA)T2D6Sgkd/0
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col1a1tm1(tetO-Fos)Wag/Col1a1+,Rag1tm1Mom/Rag1tm1Mom,Tg(KRT5-rtTA)T2D6Sgkd/0
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col1a1tm1(tetO-Fos)Wag/Col1a1+,Rag1tm1Mom/Rag1tm1Mom,Tg(KRT5-rtTA)T2D6Sgkd/0
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0008173 increased follicular B cell number "greater number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col1a1tm1(tetO-Fos)Wag/Col1a1+,Rag1tm1Mom/Rag1tm1Mom,Tg(KRT5-rtTA)T2D6Sgkd/0
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
Show

Allelic Composition: Col1a1tm1(tetO-Fos)Wag/Col1a1+,Rag1tm1Mom/Rag1tm1Mom,Tg(KRT5-rtTA)T2D6Sgkd/0
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0008782 increased B cell apoptosis "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col1a1tm1(tetO-Fos)Wag/Col1a1+,Rag1tm1Mom/Rag1tm1Mom,Tg(KRT5-rtTA)T2D6Sgkd/0
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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