ENSG00000138653


Homo sapiens

Features
Gene ID: ENSG00000138653
  
Biological name :NDST4
  
Synonyms : N-deacetylase and N-sulfotransferase 4 / NDST4 / Q9H3R1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: q26
Gene start: 114827763
Gene end: 115113876
  
Corresponding Affymetrix probe sets: 1570222_at (Human Genome U133 Plus 2.0 Array)   208334_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000264363
Ensembl peptide - ENSP00000423218
Ensembl peptide - ENSP00000483949
NCBI entrez gene - 64579     See in Manteia.
OMIM - 615039
RefSeq - XM_017008546
RefSeq - NM_022569
RefSeq - XM_017008545
RefSeq Peptide - NP_072091
swissprot - Q9H3R1
Ensembl - ENSG00000138653
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ndst3ENSDARG00000041776Danio rerio
 NDST4ENSGALG00000012015Gallus gallus
 Ndst4ENSMUSG00000027971Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NDST3 / O95803 / N-deacetylase and N-sulfotransferase 3ENSG0000016410082
NDST1 / P52848 / N-deacetylase and N-sulfotransferase 1ENSG0000007061471
NDST2 / P52849 / N-deacetylase and N-sulfotransferase 2ENSG0000016650768
AC022400.6 / bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 isoform 2 ENSG0000027291661
Q9Y663 / HS3ST3A1 / heparan sulfate-glucosamine 3-sulfotransferase 3A1ENSG0000015397613
Q9Y662 / HS3ST3B1 / heparan sulfate-glucosamine 3-sulfotransferase 3B1ENSG0000012543013
HS3ST4 / Q9Y661 / heparan sulfate-glucosamine 3-sulfotransferase 4ENSG0000018260112
HS3ST2 / Q9Y278 / heparan sulfate-glucosamine 3-sulfotransferase 2ENSG0000012225411
HS3ST1 / O14792 / heparan sulfate-glucosamine 3-sulfotransferase 1ENSG0000000258710
HS3ST6 / Q96QI5 / heparan sulfate-glucosamine 3-sulfotransferase 6ENSG0000016204010
HS3ST5 / Q8IZT8 / heparan sulfate-glucosamine 3-sulfotransferase 5ENSG0000024985310


Protein motifs (from Interpro)
Interpro ID Name
 IPR000863  Sulfotransferase domain
 IPR021930  Heparan sulphate-N-deacetylase
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR037359  Heparan sulfate sulfotransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0015012 heparan sulfate proteoglycan biosynthetic process IEA
 biological_processGO:0030210 heparin biosynthetic process IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0008146 sulfotransferase activity IEA
 molecular_functionGO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019213 deacetylase activity IEA


Pathways (from Reactome)
Pathway description
HS-GAG biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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