ENSG00000145736


Homo sapiens

Features
Gene ID: ENSG00000145736
  
Biological name :GTF2H2
  
Synonyms : general transcription factor IIH subunit 2 / GTF2H2 / Q13888
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: q13.2
Gene start: 71032670
Gene end: 71067689
  
Corresponding Affymetrix probe sets: 221540_x_at (Human Genome U133 Plus 2.0 Array)   223758_s_at (Human Genome U133 Plus 2.0 Array)   230177_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000328901
Ensembl peptide - ENSP00000428718
Ensembl peptide - ENSP00000473362
Ensembl peptide - ENSP00000473333
Ensembl peptide - ENSP00000429057
Ensembl peptide - ENSP00000274400
NCBI entrez gene - 2966     See in Manteia.
NCBI entrez gene - 728340     See in Manteia.
OMIM - 601748
RefSeq - XM_017009403
RefSeq - XM_017009404
RefSeq - XM_017009406
RefSeq - XM_017009405
RefSeq - NM_001515
RefSeq Peptide - NP_001506
swissprot - R4GMS9
swissprot - D6RAW1
swissprot - Q13888
swissprot - D6RGC9
swissprot - R4GMV2
Ensembl - ENSG00000145736
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gtf2h2ENSDARG00000016514Danio rerio
 ENSGALG00000002399Gallus gallus
 Gtf2h2ENSMUSG00000021639Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q6P1K8 / GTF2H2C / GTF2H2 family member CENSG0000018347499


Protein motifs (from Interpro)
Interpro ID Name
 IPR002035  von Willebrand factor, type A
 IPR004595  TFIIH C1-like domain
 IPR007198  Ssl1-like
 IPR012170  TFIIH subunit Ssl1/p44
 IPR013087  Zinc finger C2H2-type
 IPR036465  von Willebrand factor A-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000717 nucleotide-excision repair, DNA duplex unwinding TAS
 biological_processGO:0002031 G-protein coupled receptor internalization IMP
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006283 transcription-coupled nucleotide-excision repair TAS
 biological_processGO:0006289 nucleotide-excision repair IEA
 biological_processGO:0006293 nucleotide-excision repair, preincision complex stabilization TAS
 biological_processGO:0006294 nucleotide-excision repair, preincision complex assembly TAS
 biological_processGO:0006295 nucleotide-excision repair, DNA incision, 3"-to lesion TAS
 biological_processGO:0006296 nucleotide-excision repair, DNA incision, 5"-to lesion TAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IBA
 biological_processGO:0006361 transcription initiation from RNA polymerase I promoter TAS
 biological_processGO:0006362 transcription elongation from RNA polymerase I promoter TAS
 biological_processGO:0006363 termination of RNA polymerase I transcription TAS
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter TAS
 biological_processGO:0006368 transcription elongation from RNA polymerase II promoter TAS
 biological_processGO:0006370 7-methylguanosine mRNA capping TAS
 biological_processGO:0006412 translation IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0009411 response to UV TAS
 biological_processGO:0033683 nucleotide-excision repair, DNA incision TAS
 biological_processGO:0070911 global genome nucleotide-excision repair TAS
 cellular_componentGO:0000438 core TFIIH complex portion of holo TFIIH complex IDA
 cellular_componentGO:0000439 core TFIIH complex IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005669 transcription factor TFIID complex IDA
 cellular_componentGO:0005675 holo TFIIH complex IDA
 cellular_componentGO:0016607 nuclear speck IDA
 molecular_functionGO:0003676 nucleic acid binding TAS
 molecular_functionGO:0003700 DNA-binding transcription factor activity NAS
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008094 DNA-dependent ATPase activity IDA
 molecular_functionGO:0008135 translation factor activity, RNA binding TAS
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0008353 RNA polymerase II carboxy-terminal domain kinase activity IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047485 protein N-terminus binding IPI


Pathways (from Reactome)
Pathway description
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Tat-mediated elongation of the HIV-1 transcript
NoRC negatively regulates rRNA expression
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
RNA Polymerase II Pre-transcription Events
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of DNA Repair Genes
mRNA Capping
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase II Promoter Escape
RNA Polymerase I Chain Elongation
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase I Transcription Termination
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Pol II CTD phosphorylation and interaction with CE


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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