ENSG00000146477


Homo sapiens

Features
Gene ID: ENSG00000146477
  
Biological name :SLC22A3
  
Synonyms : O75751 / SLC22A3 / solute carrier family 22 member 3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: q25.3
Gene start: 160348268
Gene end: 160452581
  
Corresponding Affymetrix probe sets: 205421_at (Human Genome U133 Plus 2.0 Array)   242578_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000275300
NCBI entrez gene - 6581     See in Manteia.
OMIM - 604842
RefSeq - XM_017011203
RefSeq - NM_021977
RefSeq - XM_011536075
RefSeq - XM_011536076
RefSeq - XM_005267106
RefSeq Peptide - NP_068812
swissprot - O75751
Ensembl - ENSG00000146477
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 oct2ENSDARG00000058775Danio rerio
 SLC22A3ENSGALG00000020002Gallus gallus
 Q9WTW5ENSMUSG00000023828Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O15244 / SLC22A2 / solute carrier family 22 member 2ENSG0000011249950
O15245 / SLC22A1 / solute carrier family 22 member 1ENSG0000017500349
Q8TCC7 / SLC22A8 / solute carrier family 22 member 8ENSG0000014945231
Q4U2R8 / SLC22A6 / solute carrier family 22 member 6ENSG0000019790130
O76082 / SLC22A5 / solute carrier family 22 member 5ENSG0000019737530
Q9H015 / SLC22A4 / solute carrier family 22 member 4ENSG0000019720829
Q9Y694 / SLC22A7 / solute carrier family 22 member 7ENSG0000013720429
Q8N4F4 / SLC22A24 / solute carrier family 22 member 24ENSG0000019765828
Q9Y226 / SLC22A13 / solute carrier family 22 member 13ENSG0000017294028
Q63ZE4 / SLC22A10 / solute carrier family 22 member 10ENSG0000018499928
Q96S37 / SLC22A12 / solute carrier family 22 member 12ENSG0000019789128
Q8IZD6 / SLC22A15 / solute carrier family 22 member 15ENSG0000016339327
Q86VW1 / SLC22A16 / solute carrier family 22 member 16ENSG0000000480926
Q9NSA0 / SLC22A11 / solute carrier family 22 member 11ENSG0000016806525
Q9Y267 / SLC22A14 / solute carrier family 22 member 14ENSG0000014467125
Q6T423 / SLC22A25 / solute carrier family 22 member 25ENSG0000019660024
Q8IVM8 / SLC22A9 / solute carrier family 22 member 9ENSG0000014974223


Protein motifs (from Interpro)
Interpro ID Name
 IPR004749  Organic cation transport protein/SVOP
 IPR005829  Sugar transporter, conserved site
 IPR011701  Major facilitator superfamily
 IPR020846  Major facilitator superfamily domain
 IPR036259  MFS transporter superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006855 drug transmembrane transport TAS
 biological_processGO:0015695 organic cation transport IEA
 biological_processGO:0015697 quaternary ammonium group transport IDA
 biological_processGO:0015711 organic anion transport IEA
 biological_processGO:0015844 monoamine transport IEA
 biological_processGO:0015872 dopamine transport IEA
 biological_processGO:0032098 regulation of appetite IEA
 biological_processGO:0051608 histamine transport IEA
 biological_processGO:0051615 histamine uptake IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:1901998 toxin transport IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane TAS
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005215 transporter activity IEA
 molecular_functionGO:0005329 dopamine transmembrane transporter activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008514 organic anion transmembrane transporter activity IBA
 molecular_functionGO:0015101 organic cation transmembrane transporter activity IEA
 molecular_functionGO:0015651 quaternary ammonium group transmembrane transporter activity IDA
 molecular_functionGO:0019534 toxin transmembrane transporter activity IEA


Pathways (from Reactome)
Pathway description
Abacavir transmembrane transport
Organic cation transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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