ENSG00000112499


Homo sapiens

Features
Gene ID: ENSG00000112499
  
Biological name :SLC22A2
  
Synonyms : O15244 / SLC22A2 / solute carrier family 22 member 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: q25.3
Gene start: 160171061
Gene end: 160277638
  
Corresponding Affymetrix probe sets: 207429_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000355919
Ensembl peptide - ENSP00000355920
NCBI entrez gene - 6582     See in Manteia.
OMIM - 602608
RefSeq - NM_003058
RefSeq Peptide - NP_003049
swissprot - O15244
swissprot - Q5T7Q5
Ensembl - ENSG00000112499
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc22a2ENSDARG00000030530Danio rerio
 ENSGALG00000011579Gallus gallus
 ENSGALG00000011615Gallus gallus
 O70577ENSMUSG00000040966Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O15245 / SLC22A1 / solute carrier family 22 member 1ENSG0000017500370
O75751 / SLC22A3 / solute carrier family 22 member 3ENSG0000014647750
Q9H015 / SLC22A4 / solute carrier family 22 member 4ENSG0000019720832
Q8TCC7 / SLC22A8 / solute carrier family 22 member 8ENSG0000014945232
Q4U2R8 / SLC22A6 / solute carrier family 22 member 6ENSG0000019790132
O76082 / SLC22A5 / solute carrier family 22 member 5ENSG0000019737532
Q9Y226 / SLC22A13 / solute carrier family 22 member 13ENSG0000017294029
Q8IZD6 / SLC22A15 / solute carrier family 22 member 15ENSG0000016339329
Q9NSA0 / SLC22A11 / solute carrier family 22 member 11ENSG0000016806528
Q9Y694 / SLC22A7 / solute carrier family 22 member 7ENSG0000013720428
Q96S37 / SLC22A12 / solute carrier family 22 member 12ENSG0000019789128
Q8N4F4 / SLC22A24 / solute carrier family 22 member 24ENSG0000019765828
Q86VW1 / SLC22A16 / solute carrier family 22 member 16ENSG0000000480927
Q63ZE4 / SLC22A10 / solute carrier family 22 member 10ENSG0000018499926
Q9Y267 / SLC22A14 / solute carrier family 22 member 14ENSG0000014467126
Q8IVM8 / SLC22A9 / solute carrier family 22 member 9ENSG0000014974226
Q6T423 / SLC22A25 / solute carrier family 22 member 25ENSG0000019660025


Protein motifs (from Interpro)
Interpro ID Name
 IPR004749  Organic cation transport protein/SVOP
 IPR005828  Major facilitator, sugar transporter-like
 IPR005829  Sugar transporter, conserved site
 IPR020846  Major facilitator superfamily domain
 IPR036259  MFS transporter superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006812 cation transport IEA
 biological_processGO:0006836 neurotransmitter transport IBA
 biological_processGO:0006855 drug transmembrane transport TAS
 biological_processGO:0007269 neurotransmitter secretion TAS
 biological_processGO:0007589 body fluid secretion TAS
 biological_processGO:0015695 organic cation transport TAS
 biological_processGO:0015697 quaternary ammonium group transport IEA
 biological_processGO:0015711 organic anion transport IEA
 biological_processGO:0015872 dopamine transport IBA
 biological_processGO:0015874 norepinephrine transport IBA
 biological_processGO:0042136 neurotransmitter biosynthetic process TAS
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0072488 ammonium transmembrane transport IEA
 biological_processGO:1901374 acetate ester transport IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0098793 presynapse IEA
 molecular_functionGO:0005215 transporter activity IEA
 molecular_functionGO:0005277 acetylcholine transmembrane transporter activity IBA
 molecular_functionGO:0005326 neurotransmitter transporter activity TAS
 molecular_functionGO:0005329 dopamine transmembrane transporter activity IBA
 molecular_functionGO:0005333 norepinephrine transmembrane transporter activity IBA
 molecular_functionGO:0008513 secondary active organic cation transmembrane transporter activity IBA
 molecular_functionGO:0008514 organic anion transmembrane transporter activity IBA
 molecular_functionGO:0015101 organic cation transmembrane transporter activity TAS
 molecular_functionGO:0015651 quaternary ammonium group transmembrane transporter activity IBA
 molecular_functionGO:0022857 transmembrane transporter activity IEA


Pathways (from Reactome)
Pathway description
Neurotransmitter clearance
Norepinephrine Neurotransmitter Release Cycle
Abacavir transmembrane transport
Na+/Cl- dependent neurotransmitter transporters
Organic cation transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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