ENSG00000197208


Homo sapiens

Features
Gene ID: ENSG00000197208
  
Biological name :SLC22A4
  
Synonyms : Q9H015 / SLC22A4 / solute carrier family 22 member 4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q31.1
Gene start: 132294443
Gene end: 132344206
  
Corresponding Affymetrix probe sets: 205896_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000200652
NCBI entrez gene - 6583     See in Manteia.
OMIM - 604190
RefSeq - XM_017009776
RefSeq - NM_003059
RefSeq - XM_006714675
RefSeq - XM_011543589
RefSeq Peptide - NP_003050
swissprot - Q9H015
Ensembl - ENSG00000197208
  
Related genetic diseases (OMIM): 180300 - {Rheumatoid arthritis, susceptibility to}, 180300
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc22a21ENSDARG00000094112Danio rerio
 slc22a4ENSDARG00000005335Danio rerio
 slc22a5ENSDARG00000101021Danio rerio
 SLC22A4ENSGALG00000035026Gallus gallus
 Q9Z306ENSMUSG00000020334Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O76082 / SLC22A5 / solute carrier family 22 member 5ENSG0000019737577
O15245 / SLC22A1 / solute carrier family 22 member 1ENSG0000017500332
O15244 / SLC22A2 / solute carrier family 22 member 2ENSG0000011249932
Q8IZD6 / SLC22A15 / solute carrier family 22 member 15ENSG0000016339331
Q86VW1 / SLC22A16 / solute carrier family 22 member 16ENSG0000000480931
Q9Y694 / SLC22A7 / solute carrier family 22 member 7ENSG0000013720430
Q9Y226 / SLC22A13 / solute carrier family 22 member 13ENSG0000017294029
O75751 / SLC22A3 / solute carrier family 22 member 3ENSG0000014647729
Q96S37 / SLC22A12 / solute carrier family 22 member 12ENSG0000019789129
Q8TCC7 / SLC22A8 / solute carrier family 22 member 8ENSG0000014945229
Q9NSA0 / SLC22A11 / solute carrier family 22 member 11ENSG0000016806527
Q4U2R8 / SLC22A6 / solute carrier family 22 member 6ENSG0000019790127
Q8IVM8 / SLC22A9 / solute carrier family 22 member 9ENSG0000014974226
Q8N4F4 / SLC22A24 / solute carrier family 22 member 24ENSG0000019765826
Q63ZE4 / SLC22A10 / solute carrier family 22 member 10ENSG0000018499925
Q6T423 / SLC22A25 / solute carrier family 22 member 25ENSG0000019660025
Q9Y267 / SLC22A14 / solute carrier family 22 member 14ENSG0000014467122


Protein motifs (from Interpro)
Interpro ID Name
 IPR004749  Organic cation transport protein/SVOP
 IPR005828  Major facilitator, sugar transporter-like
 IPR005829  Sugar transporter, conserved site
 IPR020846  Major facilitator superfamily domain
 IPR036259  MFS transporter superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006641 triglyceride metabolic process IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0007589 body fluid secretion TAS
 biological_processGO:0009437 carnitine metabolic process IEA
 biological_processGO:0015695 organic cation transport TAS
 biological_processGO:0015697 quaternary ammonium group transport IEA
 biological_processGO:0015711 organic anion transport IEA
 biological_processGO:0015879 carnitine transport IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0098655 cation transmembrane transport IEA
 biological_processGO:1902603 carnitine transmembrane transport IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005886 plasma membrane IC
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IDA
 molecular_functionGO:0000166 nucleotide binding TAS
 molecular_functionGO:0005215 transporter activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008513 secondary active organic cation transmembrane transporter activity TAS
 molecular_functionGO:0008514 organic anion transmembrane transporter activity IBA
 molecular_functionGO:0015226 carnitine transmembrane transporter activity IEA
 molecular_functionGO:0015293 symporter activity IEA
 molecular_functionGO:0015491 cation:cation antiporter activity IDA
 molecular_functionGO:0015651 quaternary ammonium group transmembrane transporter activity IDA
 molecular_functionGO:0022857 transmembrane transporter activity IEA
 molecular_functionGO:0030165 PDZ domain binding IPI


Pathways (from Reactome)
Pathway description
Organic cation transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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