ENSG00000153395


Homo sapiens

Features
Gene ID: ENSG00000153395
  
Biological name :LPCAT1
  
Synonyms : LPCAT1 / lysophosphatidylcholine acyltransferase 1 / Q8NF37
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: p15.33
Gene start: 1456480
Gene end: 1523977
  
Corresponding Affymetrix probe sets: 201818_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000283415
Ensembl peptide - ENSP00000423472
NCBI entrez gene - 79888     See in Manteia.
OMIM - 610472
RefSeq - XM_011514134
RefSeq - NM_024830
RefSeq - XM_005248373
RefSeq - XM_011514132
RefSeq Peptide - NP_079106
swissprot - Q8NF37
Ensembl - ENSG00000153395
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LO017917.1ENSDARG00000115651Danio rerio
 lpcat1ENSDARG00000011506Danio rerio
 LPCAT1ENSGALG00000013189Gallus gallus
 Lpcat1ENSMUSG00000021608Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LPCAT2 / Q7L5N7 / lysophosphatidylcholine acyltransferase 2ENSG0000008725342
LPCAT4 / Q643R3 / lysophosphatidylcholine acyltransferase 4ENSG0000017645433


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR002123  Phospholipid/glycerol acyltransferase
 IPR011992  EF-hand domain pair


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006644 phospholipid metabolic process IEA
 biological_processGO:0006654 phosphatidic acid biosynthetic process TAS
 biological_processGO:0006656 phosphatidylcholine biosynthetic process TAS
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0008654 phospholipid biosynthetic process ISS
 biological_processGO:0036148 phosphatidylglycerol acyl-chain remodeling TAS
 biological_processGO:0036151 phosphatidylcholine acyl-chain remodeling IDA
 biological_processGO:0043129 surfactant homeostasis IEA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0045732 positive regulation of protein catabolic process IEA
 biological_processGO:0060041 retina development in camera-type eye IEA
 biological_processGO:2001246 negative regulation of phosphatidylcholine biosynthetic process IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISS
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005794 Golgi apparatus ISS
 cellular_componentGO:0005811 lipid droplet IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0035577 azurophil granule membrane TAS
 molecular_functionGO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity TAS
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047144 2-acylglycerol-3-phosphate O-acyltransferase activity TAS
 molecular_functionGO:0047159 1-alkenylglycerophosphocholine O-acyltransferase activity IEA
 molecular_functionGO:0047184 1-acylglycerophosphocholine O-acyltransferase activity ISS
 molecular_functionGO:0047191 1-alkylglycerophosphocholine O-acyltransferase activity IEA
 molecular_functionGO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity IEA


Pathways (from Reactome)
Pathway description
Acyl chain remodelling of PC
Acyl chain remodelling of PG
Synthesis of PA
Synthesis of PC
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000214530 Q9Y365 / STARD10 / StAR related lipid transfer domain containing 10  / reaction / complex






 

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