ENSMUSG00000021608


Mus musculus

Features
Gene ID: ENSMUSG00000021608
  
Biological name :Lpcat1
  
Synonyms : Lpcat1 / Lysophosphatidylcholine acyltransferase 1 / Q3TFD2
  
Possible biological names infered from orthology : Q8NF37
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: C1
Gene start: 73467197
Gene end: 73516422
  
Corresponding Affymetrix probe sets: 10406031 (MoGene1.0st)   1420293_at (Mouse Genome 430 2.0 Array)   1420294_at (Mouse Genome 430 2.0 Array)   1424459_at (Mouse Genome 430 2.0 Array)   1424460_s_at (Mouse Genome 430 2.0 Array)   1451359_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000117238
Ensembl peptide - ENSMUSP00000152190
Ensembl peptide - ENSMUSP00000117965
Ensembl peptide - ENSMUSP00000022099
NCBI entrez gene - 210992     See in Manteia.
MGI - MGI:2384812
RefSeq - NM_145376
RefSeq - XM_006517188
RefSeq Peptide - NP_663351
swissprot - D6RFA8
swissprot - Q3TFD2
swissprot - D6RE48
Ensembl - ENSMUSG00000021608
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LO017917.1ENSDARG00000115651Danio rerio
 lpcat1ENSDARG00000011506Danio rerio
 LPCAT1ENSGALG00000013189Gallus gallus
 LPCAT1ENSG00000153395Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lpcat2 / Q8BYI6 / Lysophosphatidylcholine acyltransferase 2 / Q7L5N7*ENSMUSG0000003319243
Q9D5U0 / Lpcat2b / Lysophosphatidylcholine acyltransferase 2B ENSMUSG0000003379437
Lpcat4 / Q6NVG1 / Lysophospholipid acyltransferase LPCAT4 / Q643R3* / lysophosphatidylcholine acyltransferase 4*ENSMUSG0000002713434


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR002123  Phospholipid/glycerol acyltransferase
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006644 phospholipid metabolic process IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0008654 phospholipid biosynthetic process IEA
 biological_processGO:0036151 phosphatidylcholine acyl-chain remodeling ISO
 biological_processGO:0043129 surfactant homeostasis IDA
 biological_processGO:0045732 positive regulation of protein catabolic process IDA
 biological_processGO:0060041 retina development in camera-type eye IMP
 biological_processGO:2001246 negative regulation of phosphatidylcholine biosynthetic process IDA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005811 lipid droplet IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047159 1-alkenylglycerophosphocholine O-acyltransferase activity IDA
 molecular_functionGO:0047184 1-acylglycerophosphocholine O-acyltransferase activity IEA
 molecular_functionGO:0047191 1-alkylglycerophosphocholine O-acyltransferase activity IDA
 molecular_functionGO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity IEA


Pathways (from Reactome)
Pathway description
Acyl chain remodelling of PC
Acyl chain remodelling of PG
Synthesis of PA
Synthesis of PC
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
Show

Allelic Composition: Bmp4tm5.1Bhr/Bmp4tm2.1Blh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * Swiss Webster

 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bmp4tm5.1Bhr/Bmp4tm2.1Blh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * Swiss Webster

 MP:0001182 lung hemorrhage "bleeding in the respiratory organs" [J:66345]
Show

Allelic Composition: Bmp4tm5.1Bhr/Bmp4tm2.1Blh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * Swiss Webster

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Acetm8.1Keb/Acetm8.1Keb
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Lpcat1rd11-2J/Lpcat1rd11-2J
Genetic Background: B6.Cg-Lpcat1rd11-2J/Boc

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Bmp4tm5.1Bhr/Bmp4tm2.1Blh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * Swiss Webster

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Bmp4tm5.1Bhr/Bmp4tm2.1Blh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * Swiss Webster

 MP:0002090 abnormal vision "inability or decreased ability to see " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Acetm8.1Keb/Acetm8.1Keb
Genetic Background: involves: 129 * C57BL/6

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Acetm8.1Keb/Acetm8.1Keb
Genetic Background: involves: 129 * C57BL/6

 MP:0002864 abnormal ocular fundus morphology "malformation of the posterior concave interior of the eye, consisting of the retina, the choroid, the posterior segment of the sclera, the optic disk, and blood vessels, visible by an ophthalmoscope" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Acetm8.1Keb/Acetm8.1Keb
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Lpcat1rd11-2J/Lpcat1rd11-2J
Genetic Background: B6.Cg-Lpcat1rd11-2J/Boc

 MP:0004021 abnormal rod electrophysiology "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Acetm8.1Keb/Acetm8.1Keb
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Lpcat1rd11-2J/Lpcat1rd11-2J
Genetic Background: B6.Cg-Lpcat1rd11-2J/Boc

 MP:0004022 abnormal cone electrophysiology "anomaly in the function of light adapted vision mediated by the cones" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Acetm8.1Keb/Acetm8.1Keb
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Lpcat1rd11-2J/Lpcat1rd11-2J
Genetic Background: B6.Cg-Lpcat1rd11-2J/Boc

 MP:0004777 abnormal phospholipid level "anomalous concentration of the fat derivatives in which one fatty acid has been replaced by a phosphate group" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Acetm8.1Keb/Acetm8.1Keb
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Lpcat1rd11-2J/Lpcat1rd11-2J
Genetic Background: B6.Cg-Lpcat1rd11-2J/Boc

 MP:0004782 abnormal surfactant physiology "anomaly in the production, composition or function of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmp4tm5.1Bhr/Bmp4tm2.1Blh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * Swiss Webster

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Acetm8.1Keb/Acetm8.1Keb
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Lpcat1rd11-2J/Lpcat1rd11-2J
Genetic Background: B6.Cg-Lpcat1rd11-2J/Boc

 MP:0008444 retinal cone cell degeneration "a retrogressive impairment of function or destruction of one of the photoreceptor cell types in the retina, in which the photopigment is in invaginations of the cell membrane of the outer segment" [MESH:A08.663.650.650.670.100, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Acetm8.1Keb/Acetm8.1Keb
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Lpcat1rd11-2J/Lpcat1rd11-2J
Genetic Background: B6.Cg-Lpcat1rd11-2J/Boc

 MP:0008450 retinal photoreceptor degeneration "a retrogressive impairment of function or destruction of a cell specialized to detect and transduce light, including rods and cones of the retina" [MESH:A08.663.650.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Acetm8.1Keb/Acetm8.1Keb
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Lpcat1rd11-2J/Lpcat1rd11-2J
Genetic Background: B6.Cg-Lpcat1rd11-2J/Boc

 MP:0008451 retinal rod cell degeneration "a retrogressive impairment of function or destruction of one of the photoreceptor cell types of the vertebrate retina, in which the photopigment is in stacks of membranous disks separate from the outer cell membrane" [MESH:A08.663.650.650.670.650]
Show

Allelic Composition: Acetm8.1Keb/Acetm8.1Keb
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Lpcat1rd11-2J/Lpcat1rd11-2J
Genetic Background: B6.Cg-Lpcat1rd11-2J/Boc

 MP:0008515 thin retinal outer nuclear layer "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Acetm8.1Keb/Acetm8.1Keb
Genetic Background: involves: 129 * C57BL/6

 MP:0008519 thin retinal outer plexiform layer "reduced thickness of the retinal layer that is the site of synapses between the rods and cones (axons) and the horizontal and bipolar cells (dendrites)" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Acetm8.1Keb/Acetm8.1Keb
Genetic Background: involves: 129 * C57BL/6

 MP:0008585 absent photoreceptor outer segment "absence of the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Acetm8.1Keb/Acetm8.1Keb
Genetic Background: involves: 129 * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Bmp4tm5.1Bhr/Bmp4tm2.1Blh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * Swiss Webster

 MP:0011965 decreased total retina thickness "decreased width of the retina through the center plane" [MGI:csmith]
Show

Allelic Composition: Acetm8.1Keb/Acetm8.1Keb
Genetic Background: involves: 129 * C57BL/6

 MP:0012029 abnormal electroretinogram waveform feature "any anomaly in the pattern of the graphic record of the integrated ensemble response from many vision related neuronal and glial populations as a consequence of the serial processing within the retina, represented as changes in voltage over time after visual photonic stimulation" [MGI:csmith]
Show

Allelic Composition: Acetm8.1Keb/Acetm8.1Keb
Genetic Background: involves: 129 * C57BL/6

 MP:0012144 decreased b wave amplitude "reduction in the size (height or maximum displacement) of the b wave as measured in the electroretinogram" [MGI:csmith]
Show

Allelic Composition: Acetm8.1Keb/Acetm8.1Keb
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030688 Q9JMD3 / Stard10 / START domain containing 10 / Q9Y365* / StAR related lipid transfer domain containing 10*  / complex / reaction






 

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