ENSG00000154237


Homo sapiens

Features
Gene ID: ENSG00000154237
  
Biological name :LRRK1
  
Synonyms : leucine rich repeat kinase 1 / LRRK1 / Q38SD2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: 1
Band: q26.3
Gene start: 100919215
Gene end: 101078254
  
Corresponding Affymetrix probe sets: 1565628_at (Human Genome U133 Plus 2.0 Array)   219441_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000433069
Ensembl peptide - ENSP00000431668
Ensembl peptide - ENSP00000433268
Ensembl peptide - ENSP00000436672
Ensembl peptide - ENSP00000435148
Ensembl peptide - ENSP00000373600
NCBI entrez gene - 79705     See in Manteia.
OMIM - 610986
RefSeq - XM_017022570
RefSeq - XM_011522012
RefSeq - XM_011522013
RefSeq - XM_011522014
RefSeq - XM_011522015
RefSeq - XM_011522016
RefSeq - XM_011522019
RefSeq - NM_024652
RefSeq Peptide - NP_078928
swissprot - E9PMK9
swissprot - E9PLF8
swissprot - H0YEW1
swissprot - E9PK39
swissprot - Q38SD2
Ensembl - ENSG00000154237
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lrrk1ENSDARG00000007398Danio rerio
 LRRK1ENSGALG00000007141Gallus gallus
 Lrrk1ENSMUSG00000015133Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LRRK2 / Q5S007 / leucine rich repeat kinase 2ENSG0000018890623
PRKD2 / Q9BZL6 / protein kinase D2ENSG000001052879
PRKD1 / Q15139 / protein kinase D1ENSG000001843049
PRKD3 / O94806 / protein kinase D3ENSG000001158259


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001611  Leucine-rich repeat
 IPR002110  Ankyrin repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR011009  Protein kinase-like domain superfamily
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR020683  Ankyrin repeat-containing domain
 IPR020859  Roc domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR032171  C-terminal of Roc (COR) domain
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036322  WD40-repeat-containing domain superfamily
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0036035 osteoclast development IEA
 biological_processGO:0045453 bone resorption IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050732 negative regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IGI
 biological_processGO:1902533 positive regulation of intracellular signal transduction IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0004871 obsolete signal transducer activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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