ENSG00000105287


Homo sapiens

Features
Gene ID: ENSG00000105287
  
Biological name :PRKD2
  
Synonyms : PRKD2 / protein kinase D2 / Q9BZL6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: q13.32
Gene start: 46674275
Gene end: 46717127
  
Corresponding Affymetrix probe sets: 209282_at (Human Genome U133 Plus 2.0 Array)   241669_x_at (Human Genome U133 Plus 2.0 Array)   38269_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000472913
Ensembl peptide - ENSP00000472744
Ensembl peptide - ENSP00000472987
Ensembl peptide - ENSP00000291281
Ensembl peptide - ENSP00000393978
Ensembl peptide - ENSP00000469064
Ensembl peptide - ENSP00000469106
Ensembl peptide - ENSP00000470363
Ensembl peptide - ENSP00000470442
Ensembl peptide - ENSP00000470804
Ensembl peptide - ENSP00000470919
NCBI entrez gene - 25865     See in Manteia.
OMIM - 607074
RefSeq - XM_005258716
RefSeq - NM_001079880
RefSeq - NM_001079881
RefSeq - NM_001079882
RefSeq - NM_016457
RefSeq Peptide - NP_001073351
RefSeq Peptide - NP_057541
RefSeq Peptide - NP_001073349
RefSeq Peptide - NP_001073350
swissprot - M0QXC6
swissprot - M0QZ82
swissprot - M0QZC2
swissprot - M0R2Z8
swissprot - M0R012
swissprot - M0R346
swissprot - Q9BZL6
swissprot - B4DTS2
Ensembl - ENSG00000105287
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FO704748.1ENSDARG00000087018Danio rerio
 prkd2ENSDARG00000104676Danio rerio
 Prkd2ENSMUSG00000041187Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PRKD1 / Q15139 / protein kinase D1ENSG0000018430469
PRKD3 / O94806 / protein kinase D3ENSG0000011582565
LRRK2 / Q5S007 / leucine rich repeat kinase 2ENSG0000018890621
LRRK1 / Q38SD2 / leucine rich repeat kinase 1ENSG0000015423721


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001849  Pleckstrin homology domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR015727  Protein kinase C mu-related
 IPR017441  Protein kinase, ATP binding site
 IPR020454  Diacylglycerol/phorbol-ester binding


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IMP
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0008219 cell death IMP
 biological_processGO:0010595 positive regulation of endothelial cell migration IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IDA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IMP
 biological_processGO:0030148 sphingolipid biosynthetic process TAS
 biological_processGO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway IMP
 biological_processGO:0032743 positive regulation of interleukin-2 production IEA
 biological_processGO:0032757 positive regulation of interleukin-8 production IMP
 biological_processGO:0032793 positive regulation of CREB transcription factor activity IGI
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IGI
 biological_processGO:0035556 intracellular signal transduction IMP
 biological_processGO:0035924 cellular response to vascular endothelial growth factor stimulus IMP
 biological_processGO:0038033 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway IMP
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IMP
 biological_processGO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway IMP
 biological_processGO:0045766 positive regulation of angiogenesis IMP
 biological_processGO:0045785 positive regulation of cell adhesion IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0046777 protein autophosphorylation TAS
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway IMP
 biological_processGO:0050852 T cell receptor signaling pathway IDA
 biological_processGO:0050862 positive regulation of T cell receptor signaling pathway IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IMP
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IMP
 biological_processGO:0061154 endothelial tube morphogenesis TAS
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0089700 protein kinase D signaling IGI
 biological_processGO:1901727 positive regulation of histone deacetylase activity IGI
 biological_processGO:1902533 positive regulation of intracellular signal transduction IMP
 biological_processGO:2000573 positive regulation of DNA biosynthetic process IEA
 biological_processGO:2001028 positive regulation of endothelial cell chemotaxis IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IDA
 molecular_functionGO:0004697 protein kinase C activity IEA
 molecular_functionGO:0005080 protein kinase C binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Sphingolipid de novo biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000113163 Q9Y5P4 / COL4A3BP / collagen type IV alpha 3 binding protein  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr