ENSMUSG00000041187


Mus musculus

Features
Gene ID: ENSMUSG00000041187
  
Biological name :Prkd2
  
Synonyms : Prkd2 / protein kinase D2 / Q8BZ03
  
Possible biological names infered from orthology : Q9BZL6
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: A2
Gene start: 16842902
Gene end: 16870464
  
Corresponding Affymetrix probe sets: 10550365 (MoGene1.0st)   1434333_a_at (Mouse Genome 430 2.0 Array)   1434334_at (Mouse Genome 430 2.0 Array)   1436589_x_at (Mouse Genome 430 2.0 Array)   1437509_x_at (Mouse Genome 430 2.0 Array)   1456075_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000083273
Ensembl peptide - ENSMUSP00000131192
NCBI entrez gene - 101540     See in Manteia.
MGI - MGI:2141917
RefSeq - XM_006539444
RefSeq - NM_001252458
RefSeq - NM_178900
RefSeq Peptide - NP_849231
RefSeq Peptide - NP_001239387
swissprot - Q8BZ03
Ensembl - ENSMUSG00000041187
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FO704748.1ENSDARG00000087018Danio rerio
 prkd2ENSDARG00000104676Danio rerio
 PRKD2ENSG00000105287Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prkd1 / Q62101 / protein kinase D1 / Q15139*ENSMUSG0000000268870
Prkd3 / Q8K1Y2 / protein kinase D3 / O94806*ENSMUSG0000002407065
Lrrk1 / Q3UHC2 / Leucine-rich repeat serine/threonine-protein kinase 1 / Q38SD2* / leucine rich repeat kinase 1*ENSMUSG0000001513322
Lrrk2 / Q5S006 / Leucine-rich repeat serine/threonine-protein kinase 2 / Q5S007* / leucine rich repeat kinase 2*ENSMUSG0000003627322


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001849  Pleckstrin homology domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR015727  Protein kinase C mu-related
 IPR017441  Protein kinase, ATP binding site
 IPR020454  Diacylglycerol/phorbol-ester binding


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IEA
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006468 protein phosphorylation ISO
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0008219 cell death IEA
 biological_processGO:0010595 positive regulation of endothelial cell migration IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IEA
 biological_processGO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway IEA
 biological_processGO:0032743 positive regulation of interleukin-2 production IMP
 biological_processGO:0032757 positive regulation of interleukin-8 production IEA
 biological_processGO:0032793 positive regulation of CREB transcription factor activity IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction ISO
 biological_processGO:0035924 cellular response to vascular endothelial growth factor stimulus IEA
 biological_processGO:0038033 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway IEA
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IEA
 biological_processGO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0045785 positive regulation of cell adhesion IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway IEA
 biological_processGO:0050852 T cell receptor signaling pathway IEA
 biological_processGO:0050862 positive regulation of T cell receptor signaling pathway IMP
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IDA
 biological_processGO:0089700 protein kinase D signaling IEA
 biological_processGO:1901727 positive regulation of histone deacetylase activity IEA
 biological_processGO:1902533 positive regulation of intracellular signal transduction IEA
 biological_processGO:2000573 positive regulation of DNA biosynthetic process IDA
 biological_processGO:2001028 positive regulation of endothelial cell chemotaxis IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity ISO
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0004697 protein kinase C activity IEA
 molecular_functionGO:0005080 protein kinase C binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Sphingolipid de novo biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Sik1tm1.2Berd/Sik1tm1.2Berd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Prkd2tm1.1Shoy/Prkd2tm1.1Shoy,Prkd3tm1.1Shoy/Prkd3tm1.1Shoy,Tg(BCL2)25Wehi/0,Tg(Lck-cre)1Jtak/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6JWehi * SJL/JWehi

Allelic Composition: Prkd2tm1.1Shoy/Prkd2tm1.1Shoy,Prkd3tm1.1Shoy/Prkd3tm1.1Shoy,Tg(Lck-cre)1Jtak/0,Tg(TcraTcrb)425Cbn/0
Genetic Background: involves: 129 * BALB/c * C57BL/6

Allelic Composition: Prkd2tm1.1Shoy/Prkd2tm1.1Shoy,Prkd3tm1.1Shoy/Prkd3tm1.1Shoy,Tg(Lck-cre)1Jtak/0,Tg(TcraTcrb)1100Mjb/0
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Prkd2tm1.1Shoy/Prkd2tm1.1Shoy,Prkd3tm1.1Shoy/Prkd3tm1.1Shoy,Tg(Lck-cre)1Jtak/0,Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * DBA/2J

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mapk8ip2tm1.1Gol/Mapk8ip2tm1.1Gol
Genetic Background: 129S/SvEv-Mapk8ip2tm1.1Gol

 MP:0004392 abnormal CD8-positive T cell physiology "abnormal function of the subset of T lymphocytes that express the CD8 marker on the cell surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk8ip2tm1.1Gol/Mapk8ip2tm1.1Gol
Genetic Background: 129S/SvEv-Mapk8ip2tm1.1Gol

 MP:0005091 increased double-positive T cell count "greater than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Prkd2tm1.1Shoy/Prkd2tm1.1Shoy,Prkd3tm1.1Shoy/Prkd3tm1.1Shoy,Tg(Lck-cre)1Jtak/0,Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * DBA/2J

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mapk8ip2tm1.1Gol/Mapk8ip2tm1.1Gol
Genetic Background: 129S/SvEv-Mapk8ip2tm1.1Gol

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk8ip2tm1.1Gol/Mapk8ip2tm1.1Gol
Genetic Background: 129S/SvEv-Mapk8ip2tm1.1Gol

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Mapk8ip2tm1.1Gol/Mapk8ip2tm1.1Gol
Genetic Background: 129S/SvEv-Mapk8ip2tm1.1Gol

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Mapk8ip2tm1.1Gol/Mapk8ip2tm1.1Gol
Genetic Background: 129S/SvEv-Mapk8ip2tm1.1Gol

 MP:0013588 small thymus medulla "decreased size of the inner area of thymus lobules" [MGI:Anna]
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Allelic Composition: Sik1tm1.2Berd/Sik1tm1.2Berd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021669 Q9EQG9 / Col4a3bp / Collagen type IV alpha-3-binding protein / Q9Y5P4*  / reaction






 

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