ENSMUSG00000015133


Mus musculus

Features
Gene ID: ENSMUSG00000015133
  
Biological name :Lrrk1
  
Synonyms : Leucine-rich repeat serine/threonine-protein kinase 1 / Lrrk1 / Q3UHC2
  
Possible biological names infered from orthology : leucine rich repeat kinase 1 / Q38SD2
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: C
Gene start: 66226912
Gene end: 66388350
  
Corresponding Affymetrix probe sets: 10564377 (MoGene1.0st)   1437330_at (Mouse Genome 430 2.0 Array)   1451985_at (Mouse Genome 430 2.0 Array)   1451986_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000015277
Ensembl peptide - ENSMUSP00000114938
NCBI entrez gene - 233328     See in Manteia.
MGI - MGI:2142227
RefSeq - XM_006540840
RefSeq - NM_146191
RefSeq - XM_006540838
RefSeq - XM_006540839
RefSeq Peptide - NP_666303
swissprot - F6YIW9
swissprot - Q3UHC2
Ensembl - ENSMUSG00000015133
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lrrk1ENSDARG00000007398Danio rerio
 LRRK1ENSGALG00000007141Gallus gallus
 LRRK1ENSG00000154237Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lrrk2 / Q5S006 / Leucine-rich repeat serine/threonine-protein kinase 2 / Q5S007* / leucine rich repeat kinase 2*ENSMUSG0000003627323
Prkd1 / Q62101 / protein kinase D1 / Q15139*ENSMUSG000000026889
Prkd3 / Q8K1Y2 / protein kinase D3 / O94806*ENSMUSG000000240709
Prkd2 / Q8BZ03 / protein kinase D2 / Q9BZL6*ENSMUSG000000411879


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001611  Leucine-rich repeat
 IPR002110  Ankyrin repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR011009  Protein kinase-like domain superfamily
 IPR011044  Quinoprotein amine dehydrogenase, beta chain-like
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR020683  Ankyrin repeat-containing domain
 IPR020859  Roc domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR032171  C-terminal of Roc (COR) domain
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0036035 osteoclast development IMP
 biological_processGO:0045453 bone resorption IMP
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IMP
 biological_processGO:0050732 negative regulation of peptidyl-tyrosine phosphorylation IMP
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IEA
 biological_processGO:1902533 positive regulation of intracellular signal transduction IGI
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0004871 obsolete signal transducer activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Npr2tm1Fgr/Npr2tm1Fgr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Lrrk1tm1b(KOMP)Wtsi/Lrrk1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lrrk1tm1b(KOMP)Wtsi/H

 MP:0000065 abnormal bone marrow cavities "absence or abnormal size or shape of the medullary cavities of the bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Npr2tm1Fgr/Npr2tm1Fgr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000067 osteopetrosis "excessive formation of dense trabecular bone and excessive calcified cartilage formation; may lead to anemia and extramedullary hematopoiesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Npr2tm1Fgr/Npr2tm1Fgr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000124 absent teeth "missing bony structures of the upper and lower jaws used in mastication" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Lrrk1tm1b(KOMP)Wtsi/Lrrk1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lrrk1tm1b(KOMP)Wtsi/H

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Npr2tm1Fgr/Npr2tm1Fgr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000133 abnormal long bone metaphysis morphology "malformed conical section of bone between the epiphysis and diaphysis of the long bones" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Npr2tm1Fgr/Npr2tm1Fgr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
Show

Allelic Composition: Lpin2tm1b(KOMP)Wtsi/Lpin2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lpin2tm1b(KOMP)Wtsi/Tcp

 MP:0000432 abnormal head morphology "anomalous structure or development of the portion of the body containing the brain and organs of sight, hearing, taste, and smell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lpin2tm1b(KOMP)Wtsi/Lpin2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lpin2tm1b(KOMP)Wtsi/Tcp

 MP:0000443 abnormal snout morphology "anomalous structure or development of the anterior facial part of the muzzle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lpin2tm1b(KOMP)Wtsi/Lpin2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lpin2tm1b(KOMP)Wtsi/Tcp

 MP:0000455 abnormal maxilla morphology "malformation of the upper bony framework of the mouth where the superior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lpin2tm1b(KOMP)Wtsi/Lpin2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lpin2tm1b(KOMP)Wtsi/Tcp

 MP:0000458 abnormal mandible morphology "malformation of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lpin2tm1b(KOMP)Wtsi/Lpin2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lpin2tm1b(KOMP)Wtsi/Tcp

 MP:0000552 abnormal radius morphology "malformation of the short bone of the lateral forearm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lpin2tm1b(KOMP)Wtsi/Lpin2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lpin2tm1b(KOMP)Wtsi/Tcp

 MP:0000558 abnormal tibia morphology "atructural anomaly of the medial and larger of the two bones of the lower leg" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lpin2tm1b(KOMP)Wtsi/Lpin2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lpin2tm1b(KOMP)Wtsi/Tcp

 MP:0000559 abnormal femur morphology "structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lpin2tm1b(KOMP)Wtsi/Lpin2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lpin2tm1b(KOMP)Wtsi/Tcp

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
Show

Allelic Composition: Lrrk1tm1b(KOMP)Wtsi/Lrrk1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lrrk1tm1b(KOMP)Wtsi/H

 MP:0001255 decreased body height "decreased shoulder to floor distance compared to controls" [dlb:Donna Burkart, Mouse Genome Informatics Curator]
Show

Allelic Composition: Npr2tm1Fgr/Npr2tm1Fgr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001340 abnormal eyelid morphology "malformation of the skin folds covering the front of the eyeball" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lpin2tm1b(KOMP)Wtsi/Lpin2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lpin2tm1b(KOMP)Wtsi/Tcp

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Lpin2tm1b(KOMP)Wtsi/Lpin2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lpin2tm1b(KOMP)Wtsi/Tcp

 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
Show

Allelic Composition: Npr2tm1Fgr/Npr2tm1Fgr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002100 abnormal tooth morphology "atypical size, shape or hard tissue structure of the teeth " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lpin2tm1b(KOMP)Wtsi/Lpin2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lpin2tm1b(KOMP)Wtsi/Tcp

 MP:0002187 abnormal fibula morphology "malformation of the lateral and smaller bone of the lower limb" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lpin2tm1b(KOMP)Wtsi/Lpin2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lpin2tm1b(KOMP)Wtsi/Tcp

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Npr2tm1Fgr/Npr2tm1Fgr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Lrrk1tm1b(KOMP)Wtsi/Lrrk1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lrrk1tm1b(KOMP)Wtsi/H

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Npr2tm1Fgr/Npr2tm1Fgr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002932 abnormal joint "defect in the articulation point of two or more bones" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lrrk1tm1b(KOMP)Wtsi/Lrrk1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lrrk1tm1b(KOMP)Wtsi/H

 MP:0002966 decreased circulating alkaline phosphatase level "reduced activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Npr2tm1Fgr/Npr2tm1Fgr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Npr2tm1Fgr/Npr2tm1Fgr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: Lrrk1tm1b(KOMP)Wtsi/Lrrk1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lrrk1tm1b(KOMP)Wtsi/H

 MP:0003723 abnormal long bone morphology "malformation of any of the several elongated bones of the extremities " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Npr2tm1Fgr/Npr2tm1Fgr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003743 abnormal facial morphology "anomalous structure or development of the face" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Npr2tm1Fgr/Npr2tm1Fgr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003918 decreased kidney weight "reduced heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Lrrk1tm1b(KOMP)Wtsi/Lrrk1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lrrk1tm1b(KOMP)Wtsi/H

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Lrrk1tm1b(KOMP)Wtsi/Lrrk1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lrrk1tm1b(KOMP)Wtsi/H

 MP:0004148 increased cortical bone thickness "thicker than normal superficial layer of compact bone" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Npr2tm1Fgr/Npr2tm1Fgr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004509 abnormal pelvic girdle bone morphology "any structural anomaly of the bones of the pelvis by which the limbs attach to the axial skeleton " [MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lrrk1tm1b(KOMP)Wtsi/Lrrk1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lrrk1tm1b(KOMP)Wtsi/H

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lrrk1tm1b(KOMP)Wtsi/Lrrk1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lrrk1tm1b(KOMP)Wtsi/H

 MP:0004984 increased osteoclast cell number "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Npr2tm1Fgr/Npr2tm1Fgr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004993 decreased bone resorption "reduced amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Npr2tm1Fgr/Npr2tm1Fgr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005108 abnormal ulna morphology "malformation of the medial and larger of the two bones of the forearm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132]
Show

Allelic Composition: Lrrk1tm1b(KOMP)Wtsi/Lrrk1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lrrk1tm1b(KOMP)Wtsi/H

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lrrk1tm1b(KOMP)Wtsi/Lrrk1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lrrk1tm1b(KOMP)Wtsi/H

 MP:0005270 abnormal zygomatic bone morphology "anomalous structure of the bone that forms the prominence of the cheek" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lrrk1tm1b(KOMP)Wtsi/Lrrk1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lrrk1tm1b(KOMP)Wtsi/H

 MP:0005296 abnormal humerus morphology "malformation of the bone of the forelimb that articulates with the scapula above and the radius and ulna below" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lrrk1tm1b(KOMP)Wtsi/Lrrk1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lrrk1tm1b(KOMP)Wtsi/H

 MP:0005298 abnormal clavicle morphology "malformation of the doubly curved long bone that forms part of the shoulder girdle and articulates with the sternum and the scapula" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lrrk1tm1b(KOMP)Wtsi/Lrrk1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lrrk1tm1b(KOMP)Wtsi/H

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Lrrk1tm1b(KOMP)Wtsi/Lrrk1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lrrk1tm1b(KOMP)Wtsi/H

 MP:0005422 osteosclerosis "abnormal hardening or eburnation (change in exposed subchondral bone in degenerative joint disease in which bone is converted into a dense substance with a smooth surface) of bone " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathy M Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Npr2tm1Fgr/Npr2tm1Fgr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005566 decreased blood urea nitrogen level "low circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lrrk1tm1b(KOMP)Wtsi/Lrrk1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lrrk1tm1b(KOMP)Wtsi/H

 MP:0009347 increased cancellous bone thickness "thicker than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Npr2tm1Fgr/Npr2tm1Fgr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Lrrk1tm1b(KOMP)Wtsi/Lrrk1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lrrk1tm1b(KOMP)Wtsi/H

 MP:0010123 increased bone mineral content "elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lrrk1tm1b(KOMP)Wtsi/Lrrk1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lrrk1tm1b(KOMP)Wtsi/H

 MP:0010868 increased bone trabecula number "increased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Npr2tm1Fgr/Npr2tm1Fgr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0010878 increased trabecular bone volume "increase in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Npr2tm1Fgr/Npr2tm1Fgr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Dusp1tm1Brv/Dusp1tm1Brv
Genetic Background: C3.129S2-Dusp1tm1Brv

 MP:0012072 decreased susceptibility to osteoporosis "reduced likelihood that an organism will develop a reduction in bone mass or atrophy of skeletal tissue, usually accompanied by gross changes to bone matrix, leading to bone fragility" [MGI:csmith]
Show

Allelic Composition: Npr2tm1Fgr/Npr2tm1Fgr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr