ENSMUSG00000024070


Mus musculus

Features
Gene ID: ENSMUSG00000024070
  
Biological name :Prkd3
  
Synonyms : Prkd3 / protein kinase D3 / Q8K1Y2
  
Possible biological names infered from orthology : O94806
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: E3
Gene start: 78949405
Gene end: 79020816
  
Corresponding Affymetrix probe sets: 10453026 (MoGene1.0st)   1420567_at (Mouse Genome 430 2.0 Array)   1428229_at (Mouse Genome 430 2.0 Array)   1428230_at (Mouse Genome 430 2.0 Array)   1444691_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113395
Ensembl peptide - ENSMUSP00000132004
Ensembl peptide - ENSMUSP00000003191
Ensembl peptide - ENSMUSP00000112775
Ensembl peptide - ENSMUSP00000113232
NCBI entrez gene - 75292     See in Manteia.
MGI - MGI:1922542
RefSeq - NM_001171004
RefSeq - NM_001171005
RefSeq - NM_029239
RefSeq Peptide - NP_001164476
RefSeq Peptide - NP_083515
RefSeq Peptide - NP_001164475
swissprot - Q8K1Y2
swissprot - D3YU02
swissprot - Q5FWX6
swissprot - D3Z6I0
Ensembl - ENSMUSG00000024070
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prkd3ENSDARG00000079967Danio rerio
 PRKD3ENSGALG00000010612Gallus gallus
 PRKD3ENSG00000115825Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prkd1 / Q62101 / protein kinase D1 / Q15139*ENSMUSG0000000268869
Prkd2 / Q8BZ03 / protein kinase D2 / Q9BZL6*ENSMUSG0000004118764
Lrrk1 / Q3UHC2 / Leucine-rich repeat serine/threonine-protein kinase 1 / Q38SD2* / leucine rich repeat kinase 1*ENSMUSG0000001513320
Lrrk2 / Q5S006 / Leucine-rich repeat serine/threonine-protein kinase 2 / Q5S007* / leucine rich repeat kinase 2*ENSMUSG0000003627320


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001849  Pleckstrin homology domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR015727  Protein kinase C mu-related
 IPR017441  Protein kinase, ATP binding site
 IPR020454  Diacylglycerol/phorbol-ester binding


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0089700 protein kinase D signaling IBA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004697 protein kinase C activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Sphingolipid de novo biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pzptm1Lex/Pzptm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pzptm1Lex/Pzptm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0000559 abnormal femur morphology "structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pzptm1Lex/Pzptm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Sik1tm1.2Berd/Sik1tm1.2Berd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Prkd2tm1.1Shoy/Prkd2tm1.1Shoy,Prkd3tm1.1Shoy/Prkd3tm1.1Shoy,Tg(BCL2)25Wehi/0,Tg(Lck-cre)1Jtak/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6JWehi * SJL/JWehi

Allelic Composition: Prkd2tm1.1Shoy/Prkd2tm1.1Shoy,Prkd3tm1.1Shoy/Prkd3tm1.1Shoy,Tg(Lck-cre)1Jtak/0,Tg(TcraTcrb)425Cbn/0
Genetic Background: involves: 129 * BALB/c * C57BL/6

Allelic Composition: Prkd2tm1.1Shoy/Prkd2tm1.1Shoy,Prkd3tm1.1Shoy/Prkd3tm1.1Shoy,Tg(Lck-cre)1Jtak/0,Tg(TcraTcrb)1100Mjb/0
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Prkd2tm1.1Shoy/Prkd2tm1.1Shoy,Prkd3tm1.1Shoy/Prkd3tm1.1Shoy,Tg(Lck-cre)1Jtak/0,Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * DBA/2J

 MP:0005091 increased double-positive T cell count "greater than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Prkd2tm1.1Shoy/Prkd2tm1.1Shoy,Prkd3tm1.1Shoy/Prkd3tm1.1Shoy,Tg(Lck-cre)1Jtak/0,Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * DBA/2J

 MP:0013588 small thymus medulla "decreased size of the inner area of thymus lobules" [MGI:Anna]
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Allelic Composition: Sik1tm1.2Berd/Sik1tm1.2Berd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021669 Q9EQG9 / Col4a3bp / Collagen type IV alpha-3-binding protein / Q9Y5P4*  / reaction






 

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