ENSMUSG00000002688


Mus musculus

Features
Gene ID: ENSMUSG00000002688
  
Biological name :Prkd1
  
Synonyms : Prkd1 / protein kinase D1 / Q62101
  
Possible biological names infered from orthology : Q15139
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: B3
Gene start: 50341231
Gene end: 50649098
  
Corresponding Affymetrix probe sets: 10400170 (MoGene1.0st)   1422673_at (Mouse Genome 430 2.0 Array)   1447623_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000002765
NCBI entrez gene - 18760     See in Manteia.
MGI - MGI:99879
RefSeq - XM_011244017
RefSeq - NM_008858
RefSeq - XM_006515590
RefSeq - XM_006515591
RefSeq - XM_006515586
RefSeq - XM_006515587
RefSeq Peptide - NP_032884
swissprot - Q62101
Ensembl - ENSMUSG00000002688
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prkd1ENSDARG00000075949Danio rerio
 PRKD1ENSGALG00000009900Gallus gallus
 PRKD1ENSG00000184304Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prkd3 / Q8K1Y2 / protein kinase D3 / O94806*ENSMUSG0000002407067
Prkd2 / Q8BZ03 / protein kinase D2 / Q9BZL6*ENSMUSG0000004118767
Lrrk1 / Q3UHC2 / Leucine-rich repeat serine/threonine-protein kinase 1 / Q38SD2* / leucine rich repeat kinase 1*ENSMUSG0000001513320
Lrrk2 / Q5S006 / Leucine-rich repeat serine/threonine-protein kinase 2 / Q5S007* / leucine rich repeat kinase 2*ENSMUSG0000003627319


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001849  Pleckstrin homology domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR015727  Protein kinase C mu-related
 IPR017441  Protein kinase, ATP binding site
 IPR020454  Diacylglycerol/phorbol-ester binding


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation ISO
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006468 protein phosphorylation ISS
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007030 Golgi organization ISS
 biological_processGO:0007265 Ras protein signal transduction ISS
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0010508 positive regulation of autophagy ISO
 biological_processGO:0010595 positive regulation of endothelial cell migration ISS
 biological_processGO:0010837 regulation of keratinocyte proliferation IMP
 biological_processGO:0010976 positive regulation of neuron projection development ISO
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation ISO
 biological_processGO:0018107 peptidyl-threonine phosphorylation ISO
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031647 regulation of protein stability ISO
 biological_processGO:0032793 positive regulation of CREB transcription factor activity ISO
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation ISO
 biological_processGO:0034198 cellular response to amino acid starvation ISO
 biological_processGO:0034599 cellular response to oxidative stress ISO
 biological_processGO:0035556 intracellular signal transduction ISO
 biological_processGO:0035924 cellular response to vascular endothelial growth factor stimulus ISO
 biological_processGO:0038033 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway ISO
 biological_processGO:0042993 obsolete positive regulation of transcription factor import into nucleus IMP
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling ISS
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration ISO
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045669 positive regulation of osteoblast differentiation IMP
 biological_processGO:0045766 positive regulation of angiogenesis ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0046777 protein autophosphorylation ISS
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway ISO
 biological_processGO:0048193 Golgi vesicle transport IMP
 biological_processGO:0050829 defense response to Gram-negative bacterium IMP
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity ISS
 biological_processGO:0051279 regulation of release of sequestered calcium ion into cytosol IDA
 biological_processGO:0060548 negative regulation of cell death ISS
 biological_processGO:0071447 cellular response to hydroperoxide ISO
 biological_processGO:0089700 protein kinase D signaling ISO
 biological_processGO:1901727 positive regulation of histone deacetylase activity ISO
 biological_processGO:2001028 positive regulation of endothelial cell chemotaxis ISO
 cellular_componentGO:0000421 autophagosome membrane ISO
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005802 trans-Golgi network ISO
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0005938 cell cortex IDA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0004697 protein kinase C activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Sphingolipid de novo biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001629 abnormal heart rate "greater than or fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: KitW-Btlr/KitW-Btlr
Genetic Background: C57BL/6J-KitW-Btlr

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: KitW-Btlr/KitW-Btlr
Genetic Background: C57BL/6J-KitW-Btlr

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: KitW-Btlr/KitW-Btlr
Genetic Background: C57BL/6J-KitW-Btlr

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: KitW-Btlr/KitW-Btlr
Genetic Background: C57BL/6J-KitW-Btlr

 MP:0005599 increased cardiac muscle contractility "greater than the normal ability of the heart muscle to shorten or to develop increased tension " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: KitW-Btlr/KitW-Btlr
Genetic Background: C57BL/6J-KitW-Btlr

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Mapk8ip2tm1.1Gol/Mapk8ip2tm1.1Gol
Genetic Background: 129S/SvEv-Mapk8ip2tm1.1Gol

 MP:0011102 partial embryonic lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: KitW-Btlr/KitW-Btlr
Genetic Background: C57BL/6J-KitW-Btlr

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Mapk8ip2tm1.1Gol/Mapk8ip2tm1.1Gol
Genetic Background: 129S/SvEv-Mapk8ip2tm1.1Gol

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Mapk8ip2tm1.1Gol/Mapk8ip2tm1.1Gol
Genetic Background: 129S/SvEv-Mapk8ip2tm1.1Gol

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021669 Q9EQG9 / Col4a3bp / Collagen type IV alpha-3-binding protein / Q9Y5P4*  / reaction






 

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