ENSG00000166938


Homo sapiens

Features
Gene ID: ENSG00000166938
  
Biological name :DIS3L
  
Synonyms : DIS3L / DIS3 like exosome 3-5 exoribonuclease / Q8TF46
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: 1
Band: q22.31
Gene start: 66293217
Gene end: 66333898
  
Corresponding Affymetrix probe sets: 235005_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000432125
Ensembl peptide - ENSP00000321711
Ensembl peptide - ENSP00000432407
Ensembl peptide - ENSP00000436583
Ensembl peptide - ENSP00000436573
Ensembl peptide - ENSP00000435792
Ensembl peptide - ENSP00000433504
Ensembl peptide - ENSP00000321583
NCBI entrez gene - 115752     See in Manteia.
OMIM - 614183
RefSeq - NM_001323948
RefSeq - NM_001143688
RefSeq - NM_001323936
RefSeq - NM_001323937
RefSeq - NM_001323938
RefSeq - NM_001323939
RefSeq - NM_001323940
RefSeq - NM_001323941
RefSeq - NM_001323943
RefSeq - NM_001323944
RefSeq - NM_001323945
RefSeq - NM_001323946
RefSeq - NM_133375
RefSeq - XM_005254146
RefSeq Peptide - NP_001310877
RefSeq Peptide - NP_588616
RefSeq Peptide - NP_001310869
RefSeq Peptide - NP_001310870
RefSeq Peptide - NP_001310872
RefSeq Peptide - NP_001310873
RefSeq Peptide - NP_001310874
RefSeq Peptide - NP_001310875
RefSeq Peptide - NP_001137160
RefSeq Peptide - NP_001310865
RefSeq Peptide - NP_001310866
RefSeq Peptide - NP_001310867
RefSeq Peptide - NP_001310868
swissprot - E9PI20
swissprot - Q8TF46
swissprot - E9PIL0
swissprot - E9PI27
swissprot - E9PS35
swissprot - E9PKI7
Ensembl - ENSG00000166938
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dis3lENSDARG00000053200Danio rerio
 DIS3LENSGALG00000007643Gallus gallus
 Dis3lENSMUSG00000032396Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DIS3 / Q9Y2L1 / DIS3 homolog, exosome endoribonuclease and 3-5 exoribonucleaseENSG0000008352031
DIS3L2 / Q8IYB7 / DIS3 like 3-5 exoribonuclease 2ENSG0000014453522


Protein motifs (from Interpro)
Interpro ID Name
 IPR012340  Nucleic acid-binding, OB-fold
 IPR022966  Ribonuclease II/R, conserved site
 IPR031192  DIS3-like exonuclease 1
 IPR033770  Exosome complex exonuclease RRP44, S1 domain
 IPR033771  Rrp44-like cold shock domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006364 rRNA processing IBA
 biological_processGO:0016075 rRNA catabolic process IEA
 biological_processGO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic IEA
 cellular_componentGO:0000177 cytoplasmic exosome (RNase complex) IDA
 cellular_componentGO:0000178 exosome (RNase complex) IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IDA
 molecular_functionGO:0000175 3"-5"-exoribonuclease activity IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004527 exonuclease activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019899 enzyme binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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