ENSG00000083520


Homo sapiens

Features
Gene ID: ENSG00000083520
  
Biological name :DIS3
  
Synonyms : DIS3 / DIS3 homolog, exosome endoribonuclease and 3-5 exoribonuclease / Q9Y2L1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 13
Strand: -1
Band: q21.33
Gene start: 72752169
Gene end: 72782096
  
Corresponding Affymetrix probe sets: 214194_at (Human Genome U133 Plus 2.0 Array)   218362_s_at (Human Genome U133 Plus 2.0 Array)   222607_s_at (Human Genome U133 Plus 2.0 Array)   234660_s_at (Human Genome U133 Plus 2.0 Array)   236560_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000366997
Ensembl peptide - ENSP00000367011
Ensembl peptide - ENSP00000436350
Ensembl peptide - ENSP00000440058
NCBI entrez gene - 22894     See in Manteia.
OMIM - 607533
RefSeq - NM_001128226
RefSeq - NM_001322348
RefSeq - NM_001322349
RefSeq - NM_014953
RefSeq Peptide - NP_001309277
RefSeq Peptide - NP_001121698
RefSeq Peptide - NP_055768
RefSeq Peptide - NP_001309278
swissprot - Q9Y2L1
swissprot - G3V1J5
swissprot - F2Z2C0
Ensembl - ENSG00000083520
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dis3ENSDARG00000060559Danio rerio
 DIS3ENSGALG00000016930Gallus gallus
 Dis3ENSMUSG00000033166Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DIS3L / Q8TF46 / DIS3 like exosome 3-5 exoribonucleaseENSG0000016693834
DIS3L2 / Q8IYB7 / DIS3 like 3-5 exoribonuclease 2ENSG0000014453526


Protein motifs (from Interpro)
Interpro ID Name
 IPR002716  PIN domain
 IPR012340  Nucleic acid-binding, OB-fold
 IPR022966  Ribonuclease II/R, conserved site
 IPR029060  PIN-like domain superfamily
 IPR033770  Exosome complex exonuclease RRP44, S1 domain
 IPR033771  Rrp44-like cold shock domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006364 rRNA processing TAS
 biological_processGO:0016075 rRNA catabolic process IMP
 biological_processGO:0043488 regulation of mRNA stability TAS
 biological_processGO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay TAS
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0071034 CUT catabolic process IMP
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic IEA
 cellular_componentGO:0000176 nuclear exosome (RNase complex) IDA
 cellular_componentGO:0000178 exosome (RNase complex) TAS
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane HDA
 molecular_functionGO:0000175 3"-5"-exoribonuclease activity TAS
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IMP
 molecular_functionGO:0004527 exonuclease activity IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
ATF4 activates genes
mRNA decay by 3 to 5 exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA
Major pathway of rRNA processing in the nucleolus and cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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