ENSGALG00000016930


Gallus gallus

Features
Gene ID: ENSGALG00000016930
  
Biological name :DIS3
  
Synonyms : DIS3 / DIS3 homolog, exosome endoribonuclease and 3-5 exoribonuclease
  
Possible biological names infered from orthology : Exosome complex exonuclease RRP44 / Q9CSH3 / Q9Y2L1
  
Species: Gallus gallus
  
Chr. number: 1
Strand: 1
Band:
Gene start: 156229893
Gene end: 156250889
  
Corresponding Affymetrix probe sets: GgaAffx.25134.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000027317
Ensembl peptide - ENSGALP00000062330
Ensembl peptide - ENSGALP00000045564
NCBI entrez gene - 418821     See in Manteia.
RefSeq - XM_015276953
RefSeq - XM_417016
swissprot - E1BXX6
swissprot - A0A1L1RU33
swissprot - A0A1D5NYV3
Ensembl - ENSGALG00000016930
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dis3ENSDARG00000060559Danio rerio
 DIS3ENSG00000083520Homo sapiens
 Dis3ENSMUSG00000033166Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DIS3L / DIS3 like exosome 3-5 exoribonuclease / Q8C0S1* / Q8TF46* / DIS3-like exonuclease 1 *ENSGALG0000000764334
DIS3L2 / DIS3 like 3-5 exoribonuclease 2 / Q8CI75* / Q8IYB7* / DIS3-like exonuclease 2 *ENSGALG0000000776723


Protein motifs (from Interpro)
Interpro ID Name
 IPR002716  PIN domain
 IPR012340  Nucleic acid-binding, OB-fold
 IPR022966  Ribonuclease II/R, conserved site
 IPR029060  PIN-like domain superfamily
 IPR033770  Exosome complex exonuclease RRP44, S1 domain
 IPR033771  Rrp44-like cold shock domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006364 rRNA processing IBA
 biological_processGO:0006401 RNA catabolic process IBA
 biological_processGO:0016075 rRNA catabolic process IEA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0071034 CUT catabolic process IEA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic IEA
 cellular_componentGO:0000176 nuclear exosome (RNase complex) IEA
 cellular_componentGO:0000178 exosome (RNase complex) IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000175 3"-5"-exoribonuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA


Pathways (from Reactome)
Pathway description
mRNA decay by 3 to 5 exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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