ENSDARG00000060559


Danio rerio

Features
Gene ID: ENSDARG00000060559
  
Biological name :dis3
  
Synonyms : dis3 / DIS3 exosome endoribonuclease and 3-5 exoribonuclease
  
Possible biological names infered from orthology : DIS3 homolog, exosome endoribonuclease and 3-5 exoribonuclease / Exosome complex exonuclease RRP44 / Q9CSH3 / Q9Y2L1
  
Species: Danio rerio
  
Chr. number: 1
Strand: -1
Band:
Gene start: 30736449
Gene end: 30762264
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000079889
NCBI entrez gene - 100003553     See in Manteia.
RefSeq - XM_001336814
RefSeq - XM_021471210
swissprot - E7FE01
ZFIN ID - ZDB-GENE-080213-3
Ensembl - ENSDARG00000060559
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DIS3ENSGALG00000016930Gallus gallus
 DIS3ENSG00000083520Homo sapiens
 Dis3ENSMUSG00000033166Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
dis3l / DIS3 like exosome 3-5 exoribonuclease / Q8C0S1* / Q8TF46* / DIS3-like exonuclease 1 *ENSDARG0000005320033
dis3l2 / DIS3 like 3-5 exoribonuclease 2 / Q8CI75* / Q8IYB7* / DIS3-like exonuclease 2 *ENSDARG0000003325926


Protein motifs (from Interpro)
Interpro ID Name
 IPR002716  PIN domain
 IPR012340  Nucleic acid-binding, OB-fold
 IPR022966  Ribonuclease II/R, conserved site
 IPR029060  PIN-like domain superfamily
 IPR033770  Exosome complex exonuclease RRP44, S1 domain
 IPR033771  Rrp44-like cold shock domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006364 rRNA processing IBA
 biological_processGO:0006401 RNA catabolic process IBA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic IEA
 cellular_componentGO:0000178 exosome (RNase complex) IBA
 molecular_functionGO:0000175 3"-5"-exoribonuclease activity IBA
 molecular_functionGO:0004519 endonuclease activity IBA


Pathways (from Reactome)
Pathway description
mRNA decay by 3 to 5 exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA
Major pathway of rRNA processing in the nucleolus and cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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