Manteia

ENSMUSG00000033166

Mus musculus

Features

Gene ID:	ENSMUSG00000033166

Biological name :	Dis3

Synonyms :	Dis3 / Exosome complex exonuclease RRP44 / Q9CSH3

Possible biological names infered from orthology :	DIS3 homolog, exosome endoribonuclease and 3-5 exoribonuclease / Q9Y2L1

Species:	Mus musculus

Chr. number:	14
Strand:	-1
Band:	E2.2
Gene start:	99075206
Gene end:	99099770

Corresponding Affymetrix probe sets:	10421981 (MoGene1.0st) 1426609_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000041906 Ensembl peptide - ENSMUSP00000154479 Ensembl peptide - ENSMUSP00000154489 NCBI entrez gene - 72662 See in Manteia. MGI - MGI:1919912 RefSeq - XM_017316212 RefSeq - NM_028315 RefSeq - XM_006519602 RefSeq - XM_011245207 RefSeq - XM_006519601 RefSeq Peptide - NP_082591 swissprot - Q9CSH3 Ensembl - ENSMUSG00000033166

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Dis3l / Q8C0S1 / DIS3-like exonuclease 1 / Q8TF46* / DIS3 like exosome 3-5 exoribonuclease*	ENSMUSG00000032396	35
Dis3l2 / Q8CI75 / DIS3-like exonuclease 2 / Q8IYB7* / DIS3 like 3-5 exoribonuclease 2*	ENSMUSG00000053333	25

Protein motifs (from Interpro)

Interpro ID	Name
IPR002716	PIN domain
IPR012340	Nucleic acid-binding, OB-fold
IPR022966	Ribonuclease II/R, conserved site
IPR029060	PIN-like domain superfamily
IPR033770	Exosome complex exonuclease RRP44, S1 domain
IPR033771	Rrp44-like cold shock domain

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006364	rRNA processing	IBA
biological_process	GO:0006401	RNA catabolic process	IBA
biological_process	GO:0016075	rRNA catabolic process	IEA
biological_process	GO:0065009	regulation of molecular function	IEA
biological_process	GO:0071034	CUT catabolic process	IEA
biological_process	GO:0090305	nucleic acid phosphodiester bond hydrolysis	IEA
biological_process	GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	IEA
cellular_component	GO:0000176	nuclear exosome (RNase complex)	IEA
cellular_component	GO:0000178	exosome (RNase complex)	IEA
cellular_component	GO:0005634	nucleus	ISO
cellular_component	GO:0005654	nucleoplasm	ISS
cellular_component	GO:0005730	nucleolus	IEA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005829	cytosol	IEA
molecular_function	GO:0000175	3"-5"-exoribonuclease activity	IEA
molecular_function	GO:0003723	RNA binding	IEA
molecular_function	GO:0004518	nuclease activity	IEA
molecular_function	GO:0004519	endonuclease activity	IBA
molecular_function	GO:0004527	exonuclease activity	IEA
molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	IEA
molecular_function	GO:0016787	hydrolase activity	IEA

Pathways (from Reactome)

Pathway description

mRNA decay by 3 to 5 exoribonuclease

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001303	abnormal lens morphology	"malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]	Show Allelic Composition: Diaph3^{tm1b(KOMP)Mbp}/Diaph3^{tm1b(KOMP)Mbp} Genetic Background: C57BL/6N-Diaph3^{tm1b(KOMP)Mbp}/J
MP:0001325	abnormal retina morphology	"structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Diaph3^{tm1b(KOMP)Mbp}/Diaph3^{tm1b(KOMP)Mbp} Genetic Background: C57BL/6N-Diaph3^{tm1b(KOMP)Mbp}/J
MP:0011100	complete preweaning lethality	"death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Diaph3^{tm1b(KOMP)Mbp}/Diaph3^{tm1b(KOMP)Mbp} Genetic Background: C57BL/6N-Diaph3^{tm1b(KOMP)Mbp}/J

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr