ENSMUSG00000053333


Mus musculus

Features
Gene ID: ENSMUSG00000053333
  
Biological name :Dis3l2
  
Synonyms : Dis3l2 / DIS3-like exonuclease 2 / Q8CI75
  
Possible biological names infered from orthology : DIS3 like 3-5 exoribonuclease 2 / Q8IYB7
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: C5
Gene start: 86703808
Gene end: 87050095
  
Corresponding Affymetrix probe sets: 10348096 (MoGene1.0st)   1434090_at (Mouse Genome 430 2.0 Array)   1437951_at (Mouse Genome 430 2.0 Array)   1459365_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000070506
Ensembl peptide - ENSMUSP00000132673
Ensembl peptide - ENSMUSP00000139579
NCBI entrez gene - 208718     See in Manteia.
MGI - MGI:2442555
RefSeq - XM_017319469
RefSeq - NM_001172157
RefSeq - NM_153530
RefSeq - XM_006529298
RefSeq - XM_006529300
RefSeq - XM_006529301
RefSeq Peptide - NP_001165628
RefSeq Peptide - NP_705758
swissprot - A0A087WP08
swissprot - Q8CI75
Ensembl - ENSMUSG00000053333
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dis3l2ENSDARG00000033259Danio rerio
 DIS3L2ENSGALG00000007767Gallus gallus
 DIS3L2ENSG00000144535Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dis3 / Q9CSH3 / Exosome complex exonuclease RRP44 / Q9Y2L1* / DIS3 homolog, exosome endoribonuclease and 3-5 exoribonuclease*ENSMUSG0000003316627
Dis3l / Q8C0S1 / DIS3-like exonuclease 1 / Q8TF46* / DIS3 like exosome 3-5 exoribonuclease*ENSMUSG0000003239626


Protein motifs (from Interpro)
Interpro ID Name
 IPR012340  Nucleic acid-binding, OB-fold
 IPR022966  Ribonuclease II/R, conserved site
 IPR028591  DIS3-like exonuclease 2
 IPR033771  Rrp44-like cold shock domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000278 mitotic cell cycle ISS
 biological_processGO:0000291 nuclear-transcribed mRNA catabolic process, exonucleolytic ISS
 biological_processGO:0006364 rRNA processing IBA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008285 negative regulation of cell proliferation ISS
 biological_processGO:0010587 miRNA catabolic process ISO
 biological_processGO:0019827 stem cell population maintenance IMP
 biological_processGO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3"-5" IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051306 mitotic sister chromatid separation ISS
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:0090501 RNA phosphodiester bond hydrolysis IEA
 biological_processGO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic IEA
 biological_processGO:1990074 polyuridylation-dependent mRNA catabolic process ISS
 cellular_componentGO:0000178 exosome (RNase complex) IBA
 cellular_componentGO:0000932 P-body IBA
 cellular_componentGO:0005737 cytoplasm ISS
 molecular_functionGO:0000175 3"-5"-exoribonuclease activity ISO
 molecular_functionGO:0000287 magnesium ion binding ISO
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004527 exonuclease activity IEA
 molecular_functionGO:0004540 ribonuclease activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008266 poly(U) RNA binding IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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