ENSG00000173546


Homo sapiens

Features
Gene ID: ENSG00000173546
  
Biological name :CSPG4
  
Synonyms : chondroitin sulfate proteoglycan 4 / CSPG4 / Q6UVK1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: -1
Band: q24.2
Gene start: 75674322
Gene end: 75712848
  
Corresponding Affymetrix probe sets: 204736_s_at (Human Genome U133 Plus 2.0 Array)   214297_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000312506
NCBI entrez gene - 1464     See in Manteia.
OMIM - 601172
RefSeq - NM_001897
RefSeq Peptide - NP_001888
swissprot - Q6UVK1
Ensembl - ENSG00000173546
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cspg4ENSDARG00000078227Danio rerio
 CSPG4ENSGALG00000002678Gallus gallus
 Cspg4ENSMUSG00000032911Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FREM2 / Q5SZK8 / FRAS1 related extracellular matrix protein 2ENSG0000015089318
FRAS1 / Q86XX4 / Fraser extracellular matrix complex subunit 1ENSG0000013875917
FREM3 / P0C091 / FRAS1 related extracellular matrix 3ENSG0000018309016
FREM1 / Q5H8C1 / FRAS1 related extracellular matrix 1ENSG0000016494615


Protein motifs (from Interpro)
Interpro ID Name
 IPR001791  Laminin G domain
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR013783  Immunoglobulin-like fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0008347 glial cell migration IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030203 glycosaminoglycan metabolic process TAS
 biological_processGO:0030206 chondroitin sulfate biosynthetic process TAS
 biological_processGO:0030207 chondroitin sulfate catabolic process TAS
 biological_processGO:0030208 dermatan sulfate biosynthetic process TAS
 biological_processGO:0035556 intracellular signal transduction IDA
 biological_processGO:0048771 tissue remodeling IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005796 Golgi lumen TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0009986 cell surface TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0031012 extracellular matrix IDA
 cellular_componentGO:0031258 lamellipodium membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043202 lysosomal lumen TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0019901 protein kinase binding IPI


Pathways (from Reactome)
Pathway description
A tetrasaccharide linker sequence is required for GAG synthesis
Chondroitin sulfate biosynthesis
Dermatan sulfate biosynthesis
CS/DS degradation
Defective B4GALT7 causes EDS, progeroid type
Defective B3GAT3 causes JDSSDHD
Defective CHST3 causes SEDCJD
Defective CHST14 causes EDS, musculocontractural type
Defective CHSY1 causes TPBS
Defective B3GALT6 causes EDSP2 and SEMDJL1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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