ENSMUSG00000032911


Mus musculus

Features
Gene ID: ENSMUSG00000032911
  
Biological name :Cspg4
  
Synonyms : Chondroitin sulfate proteoglycan 4 / Cspg4 / Q8VHY0
  
Possible biological names infered from orthology : Q6UVK1
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: B
Gene start: 56865033
Gene end: 56899870
  
Corresponding Affymetrix probe sets: 10585588 (MoGene1.0st)   1423341_at (Mouse Genome 430 2.0 Array)   1450944_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000038909
NCBI entrez gene - 121021     See in Manteia.
MGI - MGI:2153093
RefSeq - NM_139001
RefSeq Peptide - NP_620570
swissprot - Q8VHY0
Ensembl - ENSMUSG00000032911
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cspg4ENSDARG00000078227Danio rerio
 CSPG4ENSGALG00000002678Gallus gallus
 CSPG4ENSG00000173546Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
BC067074 / cDNA sequence BC067074ENSMUSG0000002176332
Frem2 / Q6NVD0 / FRAS1-related extracellular matrix protein 2 / Q5SZK8*ENSMUSG0000003701617
Fras1 / Q80T14 / Extracellular matrix protein FRAS1 / Q86XX4* / Fraser extracellular matrix complex subunit 1*ENSMUSG0000003468716
Frem1 / Q684R7 / FRAS1-related extracellular matrix protein 1 / Q5H8C1* / FRAS1 related extracellular matrix 1*ENSMUSG0000005904915
Frem3 / FRAS1 related extracellular matrix 3 / P0C091*ENSMUSG0000004235315


Protein motifs (from Interpro)
Interpro ID Name
 IPR001791  Laminin G domain
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR013783  Immunoglobulin-like fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IMP
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0008347 glial cell migration IDA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0048771 tissue remodeling IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0031258 lamellipodium membrane IEA
 cellular_componentGO:0042995 cell projection IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding IEA


Pathways (from Reactome)
Pathway description
A tetrasaccharide linker sequence is required for GAG synthesis
Chondroitin sulfate biosynthesis
Dermatan sulfate biosynthesis
CS/DS degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000182 increased circulating LDL cholesterol level "greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Bdnftm1Krj/Bdnftm1Krj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mfge8tm1Osa/Mfge8tm1Osa
Genetic Background: B6.129-Mfge8tm1Osa

 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
Show

Allelic Composition: Mfge8tm1Osa/Mfge8tm1Osa
Genetic Background: B6.129-Mfge8tm1Osa

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Bdnftm1Krj/Bdnftm1Krj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bdnftm1Krj/Bdnftm1Krj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Bdnftm1Krj/Bdnftm1Krj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
Show

Allelic Composition: Bdnftm1Krj/Bdnftm1Krj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tnfrsf9em2Ygch/Tnfrsf9em2Ygch
Genetic Background: NOD/ShiLtDvs-Tnfrsf9em2Ygch

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bdnftm1Krj/Bdnftm1Krj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bdnftm1Krj/Bdnftm1Krj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002971 abnormal brown fat morphology "defect in the thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Bdnftm1Krj/Bdnftm1Krj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003091 abnormal cell migration "defect in the movement of cells during developmental processes" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mfge8tm1Osa/Mfge8tm1Osa
Genetic Background: B6.129-Mfge8tm1Osa

 MP:0003212 susceptibility to age related obesity "increased probability of excessive weight gain that is progressive with age" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Bdnftm1Krj/Bdnftm1Krj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Pofut2tm2.2Bch/Pofut2tm2.2Bch
Genetic Background: B6.Cg-Pofut2tm2.2Bch

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Bdnftm1Krj/Bdnftm1Krj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005290 decreased oxygen consumption "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Bdnftm1Krj/Bdnftm1Krj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Bdnftm1Krj/Bdnftm1Krj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bdnftm1Krj/Bdnftm1Krj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005534 decreased body temperature "less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bdnftm1Krj/Bdnftm1Krj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mfge8tm1Osa/Mfge8tm1Osa
Genetic Background: B6.129-Mfge8tm1Osa

 MP:0008964 decreased carbon dioxide production "reduction in the rate at which carbon dioxide leaves the blood and enters the alveolar gas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bdnftm1Krj/Bdnftm1Krj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009131 decreased white fat cell number "reduction in the number of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bdnftm1Krj/Bdnftm1Krj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009285 increased gonadal fat pad weight "greater than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bdnftm1Krj/Bdnftm1Krj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009288 increased epididymal fat pad weight 
Show

Allelic Composition: Bdnftm1Krj/Bdnftm1Krj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009289 decreased epididymal fat pad weight 
Show

Allelic Composition: Cspg4tm1Ychan/Cspg4tm1Ychan,Olig2tm2(TVA,cre)Rth/Olig2+
Genetic Background: involves: 129 * C57BL/6N

 MP:0011049 impaired adaptive thermogenesis "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]
Show

Allelic Composition: Bdnftm1Krj/Bdnftm1Krj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011167 abnormal adipose tissue development "anomaly in the process of the formation of the connective tissue composed of fat cells enmeshed in areolar tissue" [MESH:A10.165.114, MGI:csmith]
Show

Allelic Composition: Bdnftm1Krj/Bdnftm1Krj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Pofut2tm2.2Bch/Pofut2tm2.2Bch
Genetic Background: B6.Cg-Pofut2tm2.2Bch

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr