Manteia - Molecule gene

ENSMUSG00000037016

Mus musculus

Features

Gene ID:	ENSMUSG00000037016

Biological name :	Frem2

Synonyms :	FRAS1-related extracellular matrix protein 2 / Frem2 / Q6NVD0

Possible biological names infered from orthology :	Q5SZK8

Species:	Mus musculus

Chr. number:	3
Strand:	-1
Band:	C
Gene start:	53513938
Gene end:	53657355

Corresponding Affymetrix probe sets:	10498119 (MoGene1.0st) 1457038_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000088670 NCBI entrez gene - 242022 See in Manteia. MGI - MGI:2444465 RefSeq - NM_172862 RefSeq Peptide - NP_766450 swissprot - Q6NVD0 Ensembl - ENSMUSG00000037016

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
frem2a	ENSDARG00000076856	Danio rerio
frem2b	ENSDARG00000102626	Danio rerio
FREM2	ENSGALG00000033671	Gallus gallus
FREM2	ENSG00000150893	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Frem3 / FRAS1 related extracellular matrix 3 / P0C091*	ENSMUSG00000042353	34
Fras1 / Q80T14 / Extracellular matrix protein FRAS1 / Q86XX4* / Fraser extracellular matrix complex subunit 1*	ENSMUSG00000034687	30
Frem1 / Q684R7 / FRAS1-related extracellular matrix protein 1 / Q5H8C1* / FRAS1 related extracellular matrix 1*	ENSMUSG00000059049	21
Cspg4 / Q8VHY0 / Chondroitin sulfate proteoglycan 4 / Q6UVK1*	ENSMUSG00000032911	13
BC067074 / cDNA sequence BC067074	ENSMUSG00000021763	13

Protein motifs (from Interpro)

Interpro ID	Name
IPR003644	Na-Ca exchanger/integrin-beta4
IPR013783	Immunoglobulin-like fold

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001654	eye development	IMP
biological_process	GO:0002009	morphogenesis of an epithelium	IMP
biological_process	GO:0007154	cell communication	IEA
biological_process	GO:0007155	cell adhesion	IEA
biological_process	GO:0007275	multicellular organism development	IEA
biological_process	GO:0007507	heart development	IMP
biological_process	GO:0042733	embryonic digit morphogenesis	IMP
biological_process	GO:0048839	inner ear development	IDA
cellular_component	GO:0005604	basement membrane	IDA
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0046872	metal ion binding	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000018	small ears	"outer ears of a smaller than normal size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Frem2^my-F11/Frem2^my-F11 Genetic Background: either: (involves: C3HeB/FeJ * C57BL/6J) or (involves: C3HeB/FeJ * C57BL/6J * M. m. castaneus)
MP:0000022	abnormal ear shape	"malformation of the pattern of the external ear" [J:65038]	Show Allelic Composition: Frem2^ne/Frem2^ne Genetic Background: STOCK Frem2^ne/GrsrJ
MP:0000285	abnormal cardiac valve morphology	"malformation of the membranous folds of the heart that prevent reflux of fluid" [J:18048]	Show Allelic Composition: Frem2^my-F11/Frem2^my-F11 Genetic Background: either: (involves: C3HeB/FeJ * C57BL/6J) or (involves: C3HeB/FeJ * C57BL/6J * M. m. castaneus)
MP:0000372	irregular coat pigmentation	"uneven coloration of the hair" [J:65030]	Show Allelic Composition: Mpl^tm1Wsa/Mpl^tm1Wsa,Suz12^{Gt(Betageo)1Khe}/Suz12⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
MP:0000416	sparse fur	"fur that is significantly less dense" [J:46854]	Show Allelic Composition: Igbp1^tm1Imku/Y,Tg(Lck-cre)I57Jxm/? Genetic Background: involves: 129P2/OlaHsd * ICR
MP:0000432	abnormal head morphology	"anomalous structure or development of the portion of the body containing the brain and organs of sight, hearing, taste, and smell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Igbp1^tm1Imku/Y,Tg(Lck-cre)I57Jxm/? Genetic Background: involves: 129P2/OlaHsd * ICR
MP:0000445	short snout	"reduced length of the anterior facial part of the muzzle" [J:53370]	Show Allelic Composition: Frem2^my/Frem2^my Genetic Background: Not Specified
MP:0000520	absent kidney	"missing paired organs that excrete urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]	Show Allelic Composition: Frem2^my/Frem2^my Genetic Background: MY/HuLeJ Allelic Composition: Frem2^my/Frem2^my Genetic Background: Not Specified Allelic Composition: Frem2^b2b1562Clo/Frem2^b2b1562Clo Genetic Background: C57BL/6J-Frem2^b2b1562Clo
MP:0000522	cysts in kidney cortex	"abnormal membranous sacs appearing in the renal lobules, tubules and glomeruli" [J:50844]	Show Allelic Composition: Fras1^bl/Fras1^bl,Frem2^my-Ucl/Frem2^my-Ucl Genetic Background: involves: 101/H * C3H/HeH * NMRI
MP:0000562	polydactyly	"greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Rdh10^trex/Rdh10^trex Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0000564	syndactyly	"any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Otx1^tm1Sia/Otx1⁺,Otx2^tm1Sia/Otx2⁺ Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Fras1^bl/Fras1^bl,Frem2^my-Ucl/Frem2^my-Ucl Genetic Background: involves: 101/H * C3H/HeH * NMRI Allelic Composition: Frem2^my-F11/Frem2^my-F11 Genetic Background: either: (involves: C3HeB/FeJ * C57BL/6J) or (involves: C3HeB/FeJ * C57BL/6J * M. m. castaneus) Allelic Composition: Frem2^ne/Frem2^ne Genetic Background: STOCK Frem2^ne/GrsrJ Allelic Composition: Frem2^my/Frem2^my Genetic Background: MY/HuLeJ Allelic Composition: Frem2^my/Frem2^my Genetic Background: Not Specified Allelic Composition: Frem2^b2b1562Clo/Frem2^b2b1562Clo Genetic Background: C57BL/6J-Frem2^b2b1562Clo
MP:0000565	oligodactyly	"congenital condition in which some digits or parts of digits are missing" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Igbp1^tm1Imku/Y,Tg(Lck-cre)I57Jxm/? Genetic Background: involves: 129P2/OlaHsd * ICR
MP:0000576	clubbed feet	"congenital deformation of the feet; foot is plantarflexed, inverted and adducted" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]	Show Allelic Composition: Frem2^my/Frem2^my Genetic Background: Not Specified
MP:0000929	open neural tube	"incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]	Show Allelic Composition: Frem2^my-F11/Frem2^my-F11 Genetic Background: either: (involves: C3HeB/FeJ * C57BL/6J) or (involves: C3HeB/FeJ * C57BL/6J * M. m. castaneus)
MP:0001175	abnormal lung morphology	"malformed organ of respiration" [J:35802]	Show Allelic Composition: Igbp1^tm1Imku/Y,Tg(Lck-cre)I57Jxm/? Genetic Background: involves: 129P2/OlaHsd * ICR
MP:0001286	abnormal eye development	"malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]	Show Allelic Composition: Frem2^my/Frem2^my Genetic Background: Not Specified
MP:0001293	anophthalmia	"congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]	Show Allelic Composition: Frem2^my-F11/Frem2^my-F11 Genetic Background: either: (involves: C3HeB/FeJ * C57BL/6J) or (involves: C3HeB/FeJ * C57BL/6J * M. m. castaneus) Allelic Composition: Frem2^b2b3270Clo/Frem2^b2b3270Clo Genetic Background: C57BL/6J-Frem2^b2b3270Clo
MP:0001297	microphthalmia	"reduced average size of the eyes" [J:18048]	Show Allelic Composition: Frem2^my-F11/Frem2^my-F11 Genetic Background: either: (involves: C3HeB/FeJ * C57BL/6J) or (involves: C3HeB/FeJ * C57BL/6J * M. m. castaneus) Allelic Composition: Frem2^ne/Frem2^ne Genetic Background: STOCK Frem2^ne/GrsrJ Allelic Composition: Frem2^b2b3270Clo/Frem2^b2b3270Clo Genetic Background: C57BL/6J-Frem2^b2b3270Clo
MP:0001340	abnormal eyelid morphology	"malformation of the skin folds covering the front of the eyeball" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Mpl^tm1Wsa/Mpl^tm1Wsa,Suz12^{Gt(Betageo)1Khe}/Suz12⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
MP:0001672	abnormal embryogenesis/ development	"anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ebf1^tm1Rug/Ebf1^tm1Rug Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
MP:0001891	hydroencephaly	"excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Frem2^my/Frem2^my Genetic Background: Not Specified
MP:0001914	hemorrhage	"loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Frem2^my-F11/Frem2^my-F11 Genetic Background: either: (involves: C3HeB/FeJ * C57BL/6J) or (involves: C3HeB/FeJ * C57BL/6J * M. m. castaneus)
MP:0001935	reduced litter size	"fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Frem2^ne/Frem2^ne Genetic Background: STOCK Frem2^ne/GrsrJ
MP:0002060	abnormal skin morphology	"malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]	Show Allelic Composition: Frem2^my/Frem2^my Genetic Background: Not Specified
MP:0002075	abnormal coat color	"irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Igbp1^tm1Imku/Y,Tg(Lck-cre)I57Jxm/? Genetic Background: involves: 129P2/OlaHsd * ICR
MP:0002109	abnormal limb morphology	"abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Igbp1^tm1Imku/Y,Tg(Lck-cre)I57Jxm/? Genetic Background: involves: 129P2/OlaHsd * ICR Allelic Composition: Frem2^my/Frem2^my Genetic Background: Not Specified
MP:0002110	abnormal digit morphology	"abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Igbp1^tm1Imku/Y,Tg(Lck-cre)I57Jxm/? Genetic Background: involves: 129P2/OlaHsd * ICR
MP:0002778	meroanencephaly	"type of anencephaly in which the brain and cranium are present in rudimentary form" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, il:Ira Lu , Mouse Genome Informatics Curator, J:33716]	Show Allelic Composition: Frem2^my/Frem2^my Genetic Background: Not Specified
MP:0002940	variable body spotting	"the appearance of patches of white fur at random on the coat" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Frem2^my-F11/Frem2^my-F11 Genetic Background: either: (involves: C3HeB/FeJ * C57BL/6J) or (involves: C3HeB/FeJ * C57BL/6J * M. m. castaneus)
MP:0003104	acrania	"complete or partial absence of a skull; usually associated with anencephaly" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:33716]	Show Allelic Composition: Frem2^my/Frem2^my Genetic Background: Not Specified
MP:0003743	abnormal facial morphology	"anomalous structure or development of the face" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Frem2^my/Frem2^my Genetic Background: Not Specified
MP:0003924	herniated diaphragm	"protrusion of abdominal contents into the thoracic cavity through the diaphragm" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Frem2^b2b3270Clo/Frem2^b2b3270Clo Genetic Background: C57BL/6J-Frem2^b2b3270Clo
MP:0003935	abnormal craniofacial development	"anomaly in the process of forming the face and/or cranium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Frem2^my/Frem2^my Genetic Background: Not Specified
MP:0004158	right aortic arch	"the aortic arch lies to the right of the trachea and esophagus; results from persistance of the entire right dorsal arch and involution of a segment of the left arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Frem2^b2b3270Clo/Frem2^b2b3270Clo Genetic Background: C57BL/6J-Frem2^b2b3270Clo
MP:0005242	cryptophthalmos	"congenital anomaly in which the skin is continuous over the eyeball without any indication of the formation of eyelids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83745]	Show Allelic Composition: Otx1^tm1Sia/Otx1⁺,Otx2^tm1Sia/Otx2⁺ Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Fras1^bl/Fras1^bl,Frem2^my-Ucl/Frem2^my-Ucl Genetic Background: involves: 101/H * C3H/HeH * NMRI Allelic Composition: Frem2^ne/Frem2^ne Genetic Background: STOCK Frem2^ne/GrsrJ Allelic Composition: Frem2^my/Frem2^my Genetic Background: MY/HuLeJ Allelic Composition: Frem2^b2b1562Clo/Frem2^b2b1562Clo Genetic Background: C57BL/6J-Frem2^b2b1562Clo
MP:0005579	absent outer ear	"missing auricles or external acoustic meatus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:17694]	Show Allelic Composition: Frem2^my-F11/Frem2^my-F11 Genetic Background: either: (involves: C3HeB/FeJ * C57BL/6J) or (involves: C3HeB/FeJ * C57BL/6J * M. m. castaneus)
MP:0008730	fused phalanges	"anomaly of the long bones of the digits resulting in some or all the bones being joined together" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Frem2^ne/Frem2^ne Genetic Background: STOCK Frem2^ne/GrsrJ
MP:0008854	bleb	"presence of a blister-like, nearly hemispherical structure formed during embryonic development filled with air, serous fluid or blood" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fras1^bl/Fras1^bl,Frem2^my-Ucl/Frem2^my-Ucl Genetic Background: involves: 101/H * C3H/HeH * NMRI Allelic Composition: Frem2^my/Frem2^my Genetic Background: MY/HuLeJ Allelic Composition: Frem2^my/Frem2^my Genetic Background: Not Specified
MP:0008855	eye bleb	"presence of blister-like structures formed in the eye during embryonic development that are usually filled with blood" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Frem2^my/Frem2^my Genetic Background: Not Specified
MP:0008856	fetal bleb	"presence of subepidermal blister-like structures on the skin, often on the head, formed during embryonic development and usually filled with blood" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Otx1^tm1Sia/Otx1⁺,Otx2^tm1Sia/Otx2⁺ Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Fras1^bl/Fras1^bl,Frem2^my-Ucl/Frem2^my-Ucl Genetic Background: involves: 101/H * C3H/HeH * NMRI
MP:0009674	decreased birth weight	"reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]	Show Allelic Composition: Frem2^my-F11/Frem2^my-F11 Genetic Background: either: (involves: C3HeB/FeJ * C57BL/6J) or (involves: C3HeB/FeJ * C57BL/6J * M. m. castaneus)
MP:0009743	preaxial polydactyly	"duplication of all or part of the first ray on one or more of the autopods" [PMID:19125433]	Show Allelic Composition: Frem2^my/Frem2^my Genetic Background: Not Specified
MP:0010403	atrial septal defect	"abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375]	Show Allelic Composition: Frem2^my-F11/Frem2^my-F11 Genetic Background: either: (involves: C3HeB/FeJ * C57BL/6J) or (involves: C3HeB/FeJ * C57BL/6J * M. m. castaneus)
MP:0011088	partial neonatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Frem2^my-F11/Frem2^my-F11 Genetic Background: either: (involves: C3HeB/FeJ * C57BL/6J) or (involves: C3HeB/FeJ * C57BL/6J * M. m. castaneus)
MP:0011090	partial perinatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]	Show Allelic Composition: Frem2^my/Frem2^my Genetic Background: Not Specified
MP:0011101	partial prenatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Otx1^tm1Sia/Otx1⁺,Otx2^tm1Sia/Otx2⁺ Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Fras1^bl/Fras1^bl,Frem2^my-Ucl/Frem2^my-Ucl Genetic Background: involves: 101/H * C3H/HeH * NMRI
MP:0030066	short face	"an abnormally decreased height (length) of the face" [MGI:anna]	Show Allelic Composition: Frem2^my/Frem2^my Genetic Background: Not Specified

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr