| MP:0000150 | abnormal rib morphology | "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311] |
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Tg(HTT*97Q)IXwy/0
Genetic Background: involves: 129P2/OlaHsd * FVB
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| MP:0000157 | abnormal sternum morphology | "malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212] |
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Tg(HTT*97Q)IXwy/0
Genetic Background: involves: 129P2/OlaHsd * FVB
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| MP:0000520 | absent kidney | "missing paired organs that excrete urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471] |
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Allelic Composition: Zic3Bn/Zic3Bn
Genetic Background: BNT/LeJ
Allelic Composition: Fras1tm1Chpk/Fras1tm1Chpk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10
Allelic Composition: Fras1tm1.2Pjsc/Fras1tm1.2Pjsc
Genetic Background: involves: C57BL/6 * FVB/N * SJL
Allelic Composition: Fras1bfb/Fras1bfb
Genetic Background: involves: C3H/HeH * C57BL/6JAnu
Allelic Composition: Fras1bfb/Fras1bfb
Genetic Background: involves: C57BL/6JAnu
Allelic Composition: Fras1b2b3323Clo/Fras1b2b3323Clo
Genetic Background: C57BL/6J-Fras1b2b3323Clo
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| MP:0000522 | cysts in kidney cortex | "abnormal membranous sacs appearing in the renal lobules, tubules and glomeruli" [J:50844] |
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Allelic Composition: Fras1bl/Fras1bl,Frem2my-Ucl/Frem2my-Ucl
Genetic Background: involves: 101/H * C3H/HeH * NMRI
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| MP:0000523 | cortical glomerulopathies | "any disease of the capillary plexus in the kidney cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63229] |
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Allelic Composition: Fras1tm1.2Pjsc/Fras1tm1.2Pjsc
Genetic Background: involves: C57BL/6 * FVB/N * SJL
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| MP:0000527 | abnormal kidney development | "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Zic3Bn/Zic3Bn
Genetic Background: BNT/LeJ
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| MP:0000528 | delayed kidney development | "late onset of the induction and/or differentiation of the kidney" [J:18048] |
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Allelic Composition: Zic3Bn/Zic3Bn
Genetic Background: BNT/LeJ
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| MP:0000564 | syndactyly | "any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Zic3Bn/Zic3Bn
Genetic Background: BNT/LeJ
Allelic Composition: Fras1tm1Chpk/Fras1tm1Chpk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10
Allelic Composition: Fras1bl/Fras1bl,Frem2my-Ucl/Frem2my-Ucl
Genetic Background: involves: 101/H * C3H/HeH * NMRI
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| MP:0000576 | clubbed feet | "congenital deformation of the feet; foot is plantarflexed, inverted and adducted" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295] |
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Allelic Composition: Zic3Bn/Zic3Bn
Genetic Background: BNT/LeJ
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| MP:0001175 | abnormal lung morphology | "malformed organ of respiration" [J:35802] |
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Allelic Composition: Brca2tm1Kamc/Brca2tm1Kamc
Genetic Background: involves: 129P2/OlaHsd * BALB/c
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| MP:0001176 | abnormal lung development | "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931] |
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Allelic Composition: Brca2tm1Kamc/Brca2tm1Kamc
Genetic Background: involves: 129P2/OlaHsd * BALB/c
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| MP:0001208 | blistering | "accumulation of fluid- filled thin walled structures under the epidermis or within the epidermis" [J:65039] |
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Allelic Composition: Fras1tm1Chpk/Fras1tm1Chpk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10
Allelic Composition: Fras1tm1.2Pjsc/Fras1tm1.2Pjsc
Genetic Background: involves: C57BL/6 * FVB/N * SJL
Allelic Composition: Fras1bfb/Fras1bfb
Genetic Background: involves: C57BL/6JAnu
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| MP:0001297 | microphthalmia | "reduced average size of the eyes" [J:18048] |
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Allelic Composition: Zic3Bn/Zic3Bn
Genetic Background: BNT/LeJ
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| MP:0001302 | eyelids open at birth | "widely open eyes instead of closed at perinatal stage" [J:51966] |
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Allelic Composition: Crygstm1Gwis/Crygstm1Gwis
Genetic Background: B6.129-Crygstm1Gwis
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| MP:0001914 | hemorrhage | "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Fras1tm1.2Pjsc/Fras1tm1.2Pjsc
Genetic Background: involves: C57BL/6 * FVB/N * SJL
Allelic Composition: Fras1bfb/Fras1bfb
Genetic Background: involves: C57BL/6JAnu
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| MP:0002073 | abnormal hair growth | "absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Zic3Bn/Zic3Bn
Genetic Background: BNT/LeJ
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| MP:0002092 | abnormal eye morphology | "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Tbc1d32b2b3260.1Clo/Tbc1d32b2b3260.1Clo
Genetic Background: C57BL/6J-Tbc1d32b2b3260.1Clo
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| MP:0002110 | abnormal digit morphology | "abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Tbc1d32b2b3260.1Clo/Tbc1d32b2b3260.1Clo
Genetic Background: C57BL/6J-Tbc1d32b2b3260.1Clo
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| MP:0002639 | micrognathia | "abnormally reduced size of the jaws, especially of the mandible" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Fras1b2b3323Clo/Fras1b2b3323Clo
Genetic Background: C57BL/6J-Fras1b2b3323Clo
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| MP:0002989 | small kidney | "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Zic3Bn/Zic3Bn
Genetic Background: BNT/LeJ
Allelic Composition: Fras1bfb/Fras1bfb
Genetic Background: involves: C57BL/6JAnu
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| MP:0003604 | single kidney | |
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Allelic Composition: Zic3Bn/Zic3Bn
Genetic Background: BNT/LeJ
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| MP:0003675 | kidney cysts | "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Zic3Bn/Zic3Bn
Genetic Background: BNT/LeJ
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| MP:0004007 | abnormal lung vasculature | "malformation or disorganization of the blood vessels of the lung" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Brca2tm1Kamc/Brca2tm1Kamc
Genetic Background: involves: 129P2/OlaHsd * BALB/c
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| MP:0004272 | abnormal basement membrane morphology | "anomaly in the structure, organization and/or placement of the extracellular supportive tissue adjacent to the basal surface of the epithelia, including the epithelium of muscle cells, fat cells and Schwann cells; it is comprised of type IV collagen, laminin, and sulfated proteoglycans and other components and consists of two layers, the basal lamina and the lamina reticularis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A10.272.220] |
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Allelic Composition: Zic3Bn/Zic3Bn
Genetic Background: BNT/LeJ
Allelic Composition: Fras1tm1Chpk/Fras1tm1Chpk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI
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| MP:0004322 | abnormal sternebra morphology | "any structural anomaly of one segments of the primordial sternum of the embryo; these segments fuse to form the body of the adult vertebrate sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Fras1bfb/Fras1bfb
Genetic Background: involves: C57BL/6JAnu
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| MP:0004936 | abnormal ureteric bud branching morphogenesis | "partial or complete failure of the ureteric bud to repeatedly divide into lobules during development of the kidney" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Zic3Bn/Zic3Bn
Genetic Background: BNT/LeJ
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| MP:0005242 | cryptophthalmos | "congenital anomaly in which the skin is continuous over the eyeball without any indication of the formation of eyelids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83745] |
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Allelic Composition: Zic3Bn/Zic3Bn
Genetic Background: BNT/LeJ
Allelic Composition: Fras1tm1Chpk/Fras1tm1Chpk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10
Allelic Composition: Fras1bl/Fras1bl,Frem2my-Ucl/Frem2my-Ucl
Genetic Background: involves: 101/H * C3H/HeH * NMRI
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| MP:0005264 | glomerulosclerosis | "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Fras1tm1.2Pjsc/Fras1tm1.2Pjsc
Genetic Background: involves: C57BL/6 * FVB/N * SJL
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| MP:0005287 | narrow eye opening | "less than the normal distance from one eyelid to the other " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:71350] |
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Allelic Composition: Fras1bfb/Fras1bfb
Genetic Background: involves: C57BL/6JAnu
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| MP:0005325 | abnormal glomerulus | "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Fras1tm1.2Pjsc/Fras1tm1.2Pjsc
Genetic Background: involves: C57BL/6 * FVB/N * SJL
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| MP:0006032 | abnormal ureteric bud morphology | "anomaly in the formation or development of the ureteric bud that with the metanephric mesenchyme gives rise to the kidneys " [smb:Susan M Bello, Mouse Genome Informatics Curator, J:57313:] |
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Allelic Composition: Zic3Bn/Zic3Bn
Genetic Background: BNT/LeJ
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| MP:0006382 | abnormal lung epithelium morphology | "any structural anomaly of the epithelial layer of the lung" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Fras1tm1Chpk/Fras1tm1Chpk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI
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| MP:0008854 | bleb | "presence of a blister-like, nearly hemispherical structure formed during embryonic development filled with air, serous fluid or blood" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Zic3Bn/Zic3Bn
Genetic Background: BNT/LeJ
Allelic Composition: Fras1bfb/Fras1bfb
Genetic Background: involves: C3H/HeH * C57BL/6JAnu
Allelic Composition: Fras1bfb/Fras1bfb
Genetic Background: involves: C57BL/6JAnu
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| MP:0008856 | fetal bleb | "presence of subepidermal blister-like structures on the skin, often on the head, formed during embryonic development and usually filled with blood" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Zic3Bn/Zic3Bn
Genetic Background: BNT/LeJ
Allelic Composition: Fras1bl/Fras1bl,Frem2my-Ucl/Frem2my-Ucl
Genetic Background: involves: 101/H * C3H/HeH * NMRI
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| MP:0009655 | abnormal secondary palate development | "any anomaly in the formation of the part of the palate that is formed during embryonic development when palatal projections from the inner part of the maxillary processes emerge, extend and elevate into a horizontal position above the tongue" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:16942766] |
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Allelic Composition: Fras1bfb/Fras1bfb
Genetic Background: involves: C57BL/6JAnu
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| MP:0009743 | preaxial polydactyly | "duplication of all or part of the first ray on one or more of the autopods" [PMID:19125433] |
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Allelic Composition: Fras1bfb/Fras1bfb
Genetic Background: involves: C3H/HeH * C57BL/6JAnu
Allelic Composition: Fras1bfb/Fras1bfb
Genetic Background: involves: C57BL/6JAnu
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| MP:0009887 | abnormal palatal shelf fusion at midline | "any anomaly in the process in which the palatal shelves grow toward the midline and adhere along the medial edge epithelia, forming the midline epithelial seam which disappears in later stages" [PMID:16942766] |
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Allelic Composition: Fras1bfb/Fras1bfb
Genetic Background: involves: C57BL/6JAnu
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| MP:0009890 | cleft secondary palate | "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722] |
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Allelic Composition: Fras1bfb/Fras1bfb
Genetic Background: involves: C3H/HeH * C57BL/6JAnu
Allelic Composition: Fras1bfb/Fras1bfb
Genetic Background: involves: C57BL/6JAnu
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| MP:0010418 | perimembraneous ventricular septal defect | "abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect" [http://emedicine.medscape.com] |
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Allelic Composition: Fras1b2b3323Clo/Fras1b2b3323Clo
Genetic Background: C57BL/6J-Fras1b2b3323Clo
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| MP:0010977 | fused right lung lobes | "complete or partial fusion of the right lung lobes, indicative of defective lobar septation during embryonic lung development" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Fras1tm1Chpk/Fras1tm1Chpk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI
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| MP:0010984 | abnormal metanephric mesenchyme morphology | "any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, in the developing metanephros; interactions between the ureteric bud and the metanephric mesenchyme leads to the initiation of outgrowth and repetitive branching of the UB that ultimately generates the definitive renal collecting system and induces formation of renal vesicles from the mesenchyme tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:19828308] |
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Allelic Composition: Zic3Bn/Zic3Bn
Genetic Background: BNT/LeJ
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| MP:0011099 | complete lethality throughout fetal growth and development | "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Fras1tm1Chpk/Fras1tm1Chpk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10
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| MP:0011101 | partial prenatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Zic3Bn/Zic3Bn
Genetic Background: BNT/LeJ
Allelic Composition: Fras1bl/Fras1bl,Frem2my-Ucl/Frem2my-Ucl
Genetic Background: involves: 101/H * C3H/HeH * NMRI
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| MP:0011109 | partial lethality throughout fetal growth and development | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Fras1tm1Chpk/Fras1tm1Chpk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10
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| MP:0011320 | abnormal glomerular capillary morphology | "any structural anomaly of the small branching blood vessels in the kidney glomerulus that receives blood from the kidney afferent arterioles; these capillaries are under high pressure for filtering within the glomerulus" [MGI:csmith] |
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Allelic Composition: Fras1tm1.2Pjsc/Fras1tm1.2Pjsc
Genetic Background: involves: C57BL/6 * FVB/N * SJL
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| MP:0011339 | abnormal glomerular mesangium morphology | "any structural anomaly of the inner layer of the glomerulus within the basement membrane surrounding the glomerular capillaries that contain the intraglomerular mesangial cells" [MGI:csmith] |
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Allelic Composition: Fras1tm1.2Pjsc/Fras1tm1.2Pjsc
Genetic Background: involves: C57BL/6 * FVB/N * SJL
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| MP:0011364 | abnormal metanephros morphology | "any structural anomaly of the primordium of the permanent kidney, which develops later than and caudal to the mesonephros, from the mesonephric duct and nephrogenic cord; the metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine" [GO:0001656] |
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Allelic Composition: Zic3Bn/Zic3Bn
Genetic Background: BNT/LeJ
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| MP:0011386 | increased metanephric mesenchyme apoptosis | "increase in the number of cells of the metanephric mesenchyme (MM) undergoing programmed cell death; usually due to failure of MM cells to interact with the ureteric bud (UB) tips after UB invasion" [MGI:anna] |
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Allelic Composition: Zic3Bn/Zic3Bn
Genetic Background: BNT/LeJ
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| MP:0011499 | abnormal glomerular capsule space morphology | "any structural anomaly of the luminal region between the glomerular capsule visceral and parietal layers, into which filtrate enters after passing through the filtration barrier from the glomerular capillaries" [MGI:csmith] |
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Allelic Composition: Fras1tm1.2Pjsc/Fras1tm1.2Pjsc
Genetic Background: involves: C57BL/6 * FVB/N * SJL
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