ENSDARG00000054619


Danio rerio

Features
Gene ID: ENSDARG00000054619
  
Biological name :fras1
  
Synonyms : fras1 / Fraser extracellular matrix complex subunit 1
  
Possible biological names infered from orthology : Extracellular matrix protein FRAS1 / Q80T14 / Q86XX4
  
Species: Danio rerio
  
Chr. number: 5
Strand: 1
Band:
Gene start: 38837429
Gene end: 39086768
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000071316
Ensembl peptide - ENSDARP00000138474
Ensembl peptide - ENSDARP00000116842
Ensembl peptide - ENSDARP00000088628
NCBI entrez gene - 563428     See in Manteia.
RefSeq - NM_001130840
RefSeq - XM_005165335
RefSeq - XM_009301656
RefSeq Peptide - NP_001124312
swissprot - B6IDE3
swissprot - A2BHG4
swissprot - A0A0R4IQJ3
swissprot - F1Q633
ZFIN ID - ZDB-GENE-060526-68
Ensembl - ENSDARG00000054619
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FRAS1ENSGALG00000010316Gallus gallus
 FRAS1ENSG00000138759Homo sapiens
 Fras1ENSMUSG00000034687Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
frem2a / Fras1 related extracellular matrix protein 2a / FREM2* / Q5SZK8* / Q6NVD0* / FRAS1 related extracellular matrix protein 2*ENSDARG0000007685624
frem2b / Fras1 related extracellular matrix protein 2b / FREM2* / Q5SZK8* / Q6NVD0* / FRAS1 related extracellular matrix protein 2*ENSDARG0000010262624
frem3 / Fras1 related extracellular matrix 3 / P0C091*ENSDARG0000007467724
frem1b / Fras1 related extracellular matrix 1bENSDARG0000006240212
frem1a / Fras1 related extracellular matrix 1a / FREM1* / Q5H8C1* / FRAS1 related extracellular matrix 1*ENSDARG0000006947312
si:dkey-193c22.2 / BC067074* / cDNA sequence BC067074*ENSDARG000000767359
cspg4 / chondroitin sulfate proteoglycan 4 / Q6UVK1* / Q8VHY0*ENSDARG000000782279
si:dkeyp-41f9.3 / BC067074* / cDNA sequence BC067074*ENSDARG000000756005


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR001007  VWFC domain
 IPR003644  Na-Ca exchanger/integrin-beta4
 IPR006212  Furin-like repeat
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR032822  Extracellular matrix protein FRAS1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007154 cell communication IEA
 biological_processGO:0007492 endoderm development IMP
 biological_processGO:0010669 epithelial structure maintenance IMP
 biological_processGO:0033333 fin development IMP
 biological_processGO:0033334 fin morphogenesis IMP
 biological_processGO:0048703 embryonic viscerocranium morphogenesis IMP
 biological_processGO:0071711 basement membrane organization IMP
 cellular_componentGO:0005604 basement membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031012 extracellular matrix IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000040 median fin fold median fin fold blistered , abnormal
median fin fold degenerate , abnormal
median fin fold edematous , abnormal
Show

 ZFA:0000094 blood island blood island blistered , abnormal
Show

 ZFA:0000108 fin fin malformed , abnormal
fin degenerate , abnormal
fin decreased size , abnormal
fin necrotic , abnormal
Show

 ZFA:0000180 caudal vein caudal vein blistered , abnormal
Show

 ZFA:0000292 surface structure surface structure quality , abnormal
Show

 ZFA:0000692 symplectic symplectic decreased length , abnormal
symplectic fused with ceratohyal cartilage , abnormal
symplectic variability of size , abnormal
symplectic length , abnormal
Show

 ZFA:0001058 caudal fin caudal fin blistered , abnormal
caudal fin has fewer parts of type lepidotrichium , abnormal
Show

 ZFA:0001069 ventral fin fold ventral fin fold edematous , abnormal
ventral fin fold epidermis morphology , abnormal
Show

 ZFA:0001104 pharyngeal endoderm pharyngeal endoderm increased distance pharyngeal ectoderm , abnormal
Show

 ZFA:0001128 pharyngeal pouch 1 pharyngeal pouch 1 anterior compartment absent , abnormal
pharyngeal pouch 1 dorsal compartment morphology , abnormal
pharyngeal pouch 1 morphology , abnormal
pharyngeal pouch 1 morphology , ameliorated
Show

 ZFA:0001161 pectoral fin pectoral fin has fewer parts of type lepidotrichium , abnormal
pectoral fin degenerate , abnormal
pectoral fin edematous , abnormal
Show

 ZFA:0001162 anal fin anal fin has fewer parts of type lepidotrichium , abnormal
Show

 ZFA:0001173 dorsal fin dorsal fin has fewer parts of type lepidotrichium , abnormal
Show

 ZFA:0001205 Meckel s cartilage Meckels cartilage fused with palatoquadrate cartilage , abnormal
Show

 ZFA:0001216 splanchnocranium splanchnocranium asymmetrical , abnormal
Show

 ZFA:0001399 palatoquadrate cartilage palatoquadrate cartilage mislocalised , abnormal
Show

 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage mislocalised , abnormal
Show

 ZFA:0001405 ethmoid cartilage ethmoid cartilage morphology , abnormal
Show

 ZFA:0001422 hyosymplectic cartilage hyosymplectic cartilage fused with ceratohyal cartilage , abnormal
Show

 ZFA:0001460 pharyngeal arch cartilage pharyngeal arch cartilage morphology , abnormal
Show

 ZFA:0001510 basihyal cartilage basihyal cartilage morphology , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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