ENSG00000176974


Homo sapiens

Features
Gene ID: ENSG00000176974
  
Biological name :SHMT1
  
Synonyms : P34896 / serine hydroxymethyltransferase 1 / SHMT1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: p11.2
Gene start: 18327860
Gene end: 18363563
  
Corresponding Affymetrix probe sets: 209980_s_at (Human Genome U133 Plus 2.0 Array)   217304_at (Human Genome U133 Plus 2.0 Array)   224954_at (Human Genome U133 Plus 2.0 Array)   231701_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000462227
Ensembl peptide - ENSP00000462043
Ensembl peptide - ENSP00000477782
Ensembl peptide - ENSP00000318805
Ensembl peptide - ENSP00000318868
Ensembl peptide - ENSP00000345881
Ensembl peptide - ENSP00000462041
NCBI entrez gene - 6470     See in Manteia.
OMIM - 182144
RefSeq - XM_017024960
RefSeq - NM_004169
RefSeq - NM_148918
RefSeq - XM_005256767
RefSeq - XM_011523992
RefSeq - XM_017024957
RefSeq - XM_017024958
RefSeq - XM_017024959
RefSeq - NM_001281786
RefSeq Peptide - NP_683718
RefSeq Peptide - NP_001268715
RefSeq Peptide - NP_004160
swissprot - A0A087WTD8
swissprot - P34896
swissprot - J3KRZ5
swissprot - J3KRK5
Ensembl - ENSG00000176974
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 shmt1ENSDARG00000052816Danio rerio
 SHMT1ENSGALG00000005046Gallus gallus
 Shmt1ENSMUSG00000020534Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SHMT2 / P34897 / serine hydroxymethyltransferase 2ENSG0000018219962


Protein motifs (from Interpro)
Interpro ID Name
 IPR001085  Serine hydroxymethyltransferase
 IPR015421  Pyridoxal phosphate-dependent transferase, major domain
 IPR015422  Pyridoxal phosphate-dependent transferase domain 1
 IPR015424  Pyridoxal phosphate-dependent transferase
 IPR019798  Serine hydroxymethyltransferase, pyridoxal phosphate binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006231 dTMP biosynthetic process IEA
 biological_processGO:0006544 glycine metabolic process IDA
 biological_processGO:0006545 glycine biosynthetic process IEA
 biological_processGO:0006563 L-serine metabolic process IDA
 biological_processGO:0006565 L-serine catabolic process IDA
 biological_processGO:0006730 one-carbon metabolic process IEA
 biological_processGO:0009113 purine nucleobase biosynthetic process IDA
 biological_processGO:0016579 protein deubiquitination IEA
 biological_processGO:0017148 negative regulation of translation IDA
 biological_processGO:0019264 glycine biosynthetic process from serine IEA
 biological_processGO:0035999 tetrahydrofolate interconversion IDA
 biological_processGO:0045329 carnitine biosynthetic process TAS
 biological_processGO:0046653 tetrahydrofolate metabolic process IDA
 biological_processGO:0046655 folic acid metabolic process IDA
 biological_processGO:0051262 protein tetramerization IDA
 biological_processGO:0051289 protein homotetramerization IDA
 biological_processGO:1904482 cellular response to tetrahydrofolate IDA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000900 translation repressor activity, mRNA regulatory element binding IDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004372 glycine hydroxymethyltransferase activity EXP
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008732 L-allo-threonine aldolase activity IEA
 molecular_functionGO:0016597 amino acid binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030170 pyridoxal phosphate binding IDA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0048027 mRNA 5"-UTR binding IDA
 molecular_functionGO:0070905 serine binding IDA


Pathways (from Reactome)
Pathway description
Metabolism of folate and pterines
Carnitine synthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000176974 SHMT1 / P34896 / serine hydroxymethyltransferase 1  / complex






 

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