ENSMUSG00000020534


Mus musculus

Features
Gene ID: ENSMUSG00000020534
  
Biological name :Shmt1
  
Synonyms : P50431 / serine hydroxymethyltransferase 1 (soluble) / Shmt1
  
Possible biological names infered from orthology : P34896 / serine hydroxymethyltransferase 1
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B2
Gene start: 60788104
Gene end: 60811718
  
Corresponding Affymetrix probe sets: 10386604 (MoGene1.0st)   1422198_a_at (Mouse Genome 430 2.0 Array)   1425177_at (Mouse Genome 430 2.0 Array)   1425178_s_at (Mouse Genome 430 2.0 Array)   1425179_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000018744
Ensembl peptide - ENSMUSP00000134269
Ensembl peptide - ENSMUSP00000134318
Ensembl peptide - ENSMUSP00000134703
NCBI entrez gene - 20425     See in Manteia.
MGI - MGI:98299
RefSeq - XM_006532644
RefSeq - NM_009171
RefSeq Peptide - NP_033197
swissprot - G3UZ26
swissprot - G3UYY1
swissprot - P50431
swissprot - G3UZZ9
Ensembl - ENSMUSG00000020534
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 shmt1ENSDARG00000052816Danio rerio
 SHMT1ENSGALG00000005046Gallus gallus
 SHMT1ENSG00000176974Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Shmt2 / serine hydroxymethyltransferase 2 (mitochondrial) / P34897* / serine hydroxymethyltransferase 2*ENSMUSG0000002540362


Protein motifs (from Interpro)
Interpro ID Name
 IPR001085  Serine hydroxymethyltransferase
 IPR015421  Pyridoxal phosphate-dependent transferase, major domain
 IPR015422  Pyridoxal phosphate-dependent transferase domain 1
 IPR015424  Pyridoxal phosphate-dependent transferase
 IPR019798  Serine hydroxymethyltransferase, pyridoxal phosphate binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006231 dTMP biosynthetic process IMP
 biological_processGO:0006544 glycine metabolic process IEA
 biological_processGO:0006563 L-serine metabolic process IEA
 biological_processGO:0006565 L-serine catabolic process IEA
 biological_processGO:0006730 one-carbon metabolic process IEA
 biological_processGO:0009113 purine nucleobase biosynthetic process IEA
 biological_processGO:0017148 negative regulation of translation IEA
 biological_processGO:0019264 glycine biosynthetic process from serine IEA
 biological_processGO:0035999 tetrahydrofolate interconversion IEA
 biological_processGO:0046653 tetrahydrofolate metabolic process IEA
 biological_processGO:0046655 folic acid metabolic process IEA
 biological_processGO:0051262 protein tetramerization IEA
 biological_processGO:0051289 protein homotetramerization IEA
 biological_processGO:1904482 cellular response to tetrahydrofolate IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000900 translation repressor activity, mRNA regulatory element binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004372 glycine hydroxymethyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030170 pyridoxal phosphate binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0048027 mRNA 5"-UTR binding IEA
 molecular_functionGO:0070905 serine binding IEA


Pathways (from Reactome)
Pathway description
Metabolism of folate and pterines
Carnitine synthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Shmt1tm1Stov/Shmt1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Shmt1tm1.1Stov/Shmt1+
Genetic Background: 129S/SvEv-Shmt1tm1.1Stov

Allelic Composition: Shmt1tm1.1Stov/Shmt1tm1.1Stov
Genetic Background: 129S/SvEv-Shmt1tm1.1Stov

 MP:0003721 increased tumor growth/size "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Lama1tm1.1Arhi/Lama1tm1.2Arhi,Edil3Tg(Sox2-cre)1Amc/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005311 abnormal circulating amino acid level "aberrant concentration in the blood of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:83263]
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Allelic Composition: Pak7tm1Amin/Pak7tm1Amin
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Shmt1tm1Stov/Shmt1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020534 Shmt1 / P50431 / serine hydroxymethyltransferase 1 (soluble) / P34896* / serine hydroxymethyltransferase 1*  / complex






 

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