ENSMUSG00000025403


Mus musculus

Features
Gene ID: ENSMUSG00000025403
  
Biological name :Shmt2
  
Synonyms : serine hydroxymethyltransferase 2 (mitochondrial) / Shmt2
  
Possible biological names infered from orthology : P34897 / serine hydroxymethyltransferase 2
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: D3
Gene start: 127517123
Gene end: 127522444
  
Corresponding Affymetrix probe sets: 10373202 (MoGene1.0st)   1426423_at (Mouse Genome 430 2.0 Array)   1434204_x_at (Mouse Genome 430 2.0 Array)   1455084_x_at (Mouse Genome 430 2.0 Array)   1455985_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026470
Ensembl peptide - ENSMUSP00000151616
NCBI entrez gene - 108037     See in Manteia.
MGI - MGI:1277989
RefSeq - NM_028230
RefSeq - NM_001252316
RefSeq Peptide - NP_001239245
RefSeq Peptide - NP_082506
swissprot - Q3TFD0
swissprot - Q9CZN7
Ensembl - ENSMUSG00000025403
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 shmt2ENSDARG00000104414Danio rerio
 SHMT2ENSG00000182199Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Shmt1 / P50431 / serine hydroxymethyltransferase 1 (soluble) / P34896* / serine hydroxymethyltransferase 1*ENSMUSG0000002053459


Protein motifs (from Interpro)
Interpro ID Name
 IPR001085  Serine hydroxymethyltransferase
 IPR015421  Pyridoxal phosphate-dependent transferase, major domain
 IPR015422  Pyridoxal phosphate-dependent transferase domain 1
 IPR015424  Pyridoxal phosphate-dependent transferase
 IPR019798  Serine hydroxymethyltransferase, pyridoxal phosphate binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006544 glycine metabolic process IEA
 biological_processGO:0006545 glycine biosynthetic process IEA
 biological_processGO:0006563 L-serine metabolic process IEA
 biological_processGO:0006564 L-serine biosynthetic process IEA
 biological_processGO:0006730 one-carbon metabolic process ISO
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0019264 glycine biosynthetic process from serine IEA
 biological_processGO:0034340 response to type I interferon IEA
 biological_processGO:0035999 tetrahydrofolate interconversion IEA
 biological_processGO:0046653 tetrahydrofolate metabolic process IEA
 biological_processGO:0051262 protein tetramerization IEA
 biological_processGO:0051289 protein homotetramerization IEA
 biological_processGO:0070536 protein K63-linked deubiquitination IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005758 mitochondrial intermembrane space IEA
 cellular_componentGO:0005759 mitochondrial matrix IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IEA
 cellular_componentGO:0042645 mitochondrial nucleoid IEA
 cellular_componentGO:0070552 BRISC complex IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004372 glycine hydroxymethyltransferase activity ISO
 molecular_functionGO:0008732 L-allo-threonine aldolase activity IEA
 molecular_functionGO:0016597 amino acid binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030170 pyridoxal phosphate binding ISO
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Metabolism of folate and pterines


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Cnot1tm1Tya/Cnot1tm1Tya,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj * FVB

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Cnot1tm1Tya/Cnot1tm1Tya,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj * FVB

 MP:0010955 abnormal respiratory electron transport chain "anomaly in the process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient" [GO:0022904]
Show

Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Cnot1tm1Tya/Cnot1tm1Tya,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj * FVB

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Cnot1tm1Tya/Cnot1tm1Tya,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj * FVB

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Cnot1tm1Tya/Cnot1tm1Tya,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj * FVB

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025403 Shmt2 / serine hydroxymethyltransferase 2 (mitochondrial) / P34897* / serine hydroxymethyltransferase 2*  / complex






 

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