ENSG00000182199


Homo sapiens

Features
Gene ID: ENSG00000182199
  
Biological name :SHMT2
  
Synonyms : P34897 / serine hydroxymethyltransferase 2 / SHMT2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q13.3
Gene start: 57229327
Gene end: 57234935
  
Corresponding Affymetrix probe sets: 214095_at (Human Genome U133 Plus 2.0 Array)   214096_s_at (Human Genome U133 Plus 2.0 Array)   214437_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000452404
Ensembl peptide - ENSP00000452339
Ensembl peptide - ENSP00000452419
Ensembl peptide - ENSP00000333667
Ensembl peptide - ENSP00000406881
Ensembl peptide - ENSP00000413770
Ensembl peptide - ENSP00000450452
Ensembl peptide - ENSP00000450490
Ensembl peptide - ENSP00000450594
Ensembl peptide - ENSP00000450610
Ensembl peptide - ENSP00000450893
Ensembl peptide - ENSP00000450927
Ensembl peptide - ENSP00000450930
Ensembl peptide - ENSP00000451169
Ensembl peptide - ENSP00000451371
Ensembl peptide - ENSP00000451495
Ensembl peptide - ENSP00000451630
Ensembl peptide - ENSP00000451872
Ensembl peptide - ENSP00000451968
Ensembl peptide - ENSP00000452035
Ensembl peptide - ENSP00000452045
Ensembl peptide - ENSP00000452161
Ensembl peptide - ENSP00000452163
Ensembl peptide - ENSP00000452315
NCBI entrez gene - 6472     See in Manteia.
OMIM - 138450
RefSeq - NM_001166357
RefSeq - NM_001166356
RefSeq - NM_001166358
RefSeq - NM_001166359
RefSeq - NM_005412
RefSeq - XM_011538675
RefSeq - XM_011538676
RefSeq - XM_011538677
RefSeq - XM_011538678
RefSeq Peptide - NP_001159829
RefSeq Peptide - NP_001159830
RefSeq Peptide - NP_001159831
RefSeq Peptide - NP_005403
RefSeq Peptide - NP_001159828
swissprot - H0YIZ0
swissprot - A0A024RB99
swissprot - P34897
swissprot - V9HW06
swissprot - G3V241
swissprot - G3V2D2
swissprot - G3V2E4
swissprot - G3V2W0
swissprot - G3V2Y1
swissprot - G3V2Y4
swissprot - G3V3C6
swissprot - G3V4T0
swissprot - G3V3Y8
swissprot - G3V4W5
swissprot - G3V4X0
swissprot - G3V540
swissprot - G3V5L0
Ensembl - ENSG00000182199
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 shmt2ENSDARG00000104414Danio rerio
 Shmt2ENSMUSG00000025403Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SHMT1 / P34896 / serine hydroxymethyltransferase 1ENSG0000017697459


Protein motifs (from Interpro)
Interpro ID Name
 IPR001085  Serine hydroxymethyltransferase
 IPR015421  Pyridoxal phosphate-dependent transferase, major domain
 IPR015422  Pyridoxal phosphate-dependent transferase domain 1
 IPR015424  Pyridoxal phosphate-dependent transferase
 IPR019798  Serine hydroxymethyltransferase, pyridoxal phosphate binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006544 glycine metabolic process IDA
 biological_processGO:0006545 glycine biosynthetic process IEA
 biological_processGO:0006563 L-serine metabolic process IDA
 biological_processGO:0006564 L-serine biosynthetic process IEA
 biological_processGO:0006730 one-carbon metabolic process IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0019264 glycine biosynthetic process from serine IEA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0034340 response to type I interferon IDA
 biological_processGO:0035999 tetrahydrofolate interconversion IEA
 biological_processGO:0046653 tetrahydrofolate metabolic process IDA
 biological_processGO:0046655 folic acid metabolic process TAS
 biological_processGO:0051262 protein tetramerization IDA
 biological_processGO:0051289 protein homotetramerization IEA
 biological_processGO:0070536 protein K63-linked deubiquitination IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005743 mitochondrial inner membrane TAS
 cellular_componentGO:0005758 mitochondrial intermembrane space IEA
 cellular_componentGO:0005759 mitochondrial matrix IDA
 cellular_componentGO:0015630 microtubule cytoskeleton IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0042645 mitochondrial nucleoid IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0070552 BRISC complex IDA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004372 glycine hydroxymethyltransferase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0008732 L-allo-threonine aldolase activity IEA
 molecular_functionGO:0016597 amino acid binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030170 pyridoxal phosphate binding IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Metabolism of folate and pterines


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000182199 SHMT2 / P34897 / serine hydroxymethyltransferase 2  / complex






 

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contact: otassy@igbmc.fr