ENSG00000178235


Homo sapiens

Features
Gene ID: ENSG00000178235
  
Biological name :SLITRK1
  
Synonyms : Q96PX8 / SLIT and NTRK like family member 1 / SLITRK1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 13
Strand: -1
Band: q31.1
Gene start: 83877205
Gene end: 83882393
  
Corresponding Affymetrix probe sets: 236734_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000366288
NCBI entrez gene - 114798     See in Manteia.
OMIM - 609678
RefSeq - NM_052910
RefSeq - NM_001281503
RefSeq Peptide - NP_001268432
RefSeq Peptide - NP_443142
swissprot - Q96PX8
Ensembl - ENSG00000178235
  
Related genetic diseases (OMIM): 137580 - Tourette syndrome, 137580
  613229 - ?Trichotillomania, 613229
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SLITRK1ENSGALG00000016905Gallus gallus
 Q810C1ENSMUSG00000075478Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O96002 / Q9H156 / SLITRK2 / SLIT and NTRK like family member 2ENSG0000018598541
Q8IW52 / SLITRK4 / SLIT and NTRK like family member 4ENSG0000017954241
O94991 / SLITRK5 / SLIT and NTRK like family member 5ENSG0000016530041
O94933 / SLITRK3 / SLIT and NTRK like family member 3ENSG0000012187139
Q9H5Y7 / SLITRK6 / SLIT and NTRK like family member 6ENSG0000018456438
ELFN1 / P0C7U0 / extracellular leucine rich repeat and fibronectin type III domain containing 1ENSG0000022596813
ELFN2 / Q5R3F8 / extracellular leucine rich repeat and fibronectin type III domain containing 2ENSG0000016689713
LRRC19 / Q9H756 / leucine rich repeat containing 19ENSG0000018443410


Protein motifs (from Interpro)
Interpro ID Name
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007409 axonogenesis IEA
 biological_processGO:0007416 synapse assembly IMP
 biological_processGO:0030534 adult behavior IEA
 biological_processGO:0035264 multicellular organism growth IEA
 biological_processGO:0042592 homeostatic process IEA
 biological_processGO:0050772 positive regulation of axonogenesis IMP
 biological_processGO:0051965 positive regulation of synapse assembly IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0045202 synapse ISS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Receptor-type tyrosine-protein phosphatases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000006 Autosomal dominant inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele." [HPO:curators]
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 HP:0000718 Aggressive behavior "Aggressive behavior can denote verbal aggression, physical aggression against objects, physical aggression against people, and may also include aggression towards oneself." [HPO:curators]
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 HP:0000722 Obsessive-compulsive disorder 
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 HP:0000742 Self-mutilation 
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 HP:0001426 Multifactorial 
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 HP:0001596 Alopecia "Loss of hair from the head or body." [HPO:curators]
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 HP:0002360 Sleep disturbances "An abnormality of sleep including such phenomena as 1) insomnia/hypersomnia, 2) non-restorative sleep, 3) sleep schedule disorder, 4) excessive daytime somnolence, 5) sleep apnea, and 6) restlessness." [HPO:curators]
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 HP:0007018 Attention deficit hyperactivity disorder "Attention deficit hyperactivity disorder (ADHD) manifests at age 2-3 years or by first grade at the latest. The main symptoms are distractibility, impulsivity, hyperactivity, and often trouble organizing tasks and projects, difficulty going to sleep, and social problems from being aggressive, loud, or impatient." [HPO:curators]
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 HP:0010529 Echolalia "The tendency to repeat vocalizations made by another person." [HPO:curators]
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 HP:0012167 Hair-pulling "A phenomenon in which persons repetitively pull out their own hair, resulting in noticeable hair loss." [HPO:probinson]
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 HP:0100034 Motor tics "Movement-based tics affecting discrete muscle groups." [HPO:sdoelken]
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 HP:0100035 Phonic tics "Involuntary sounds produced by moving air through the nose, mouth, or throat. The vocal cords are not involved in all tics that produce sound." [HPO:sdoelken]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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