ENSMUSG00000075478


Mus musculus

Features
Gene ID: ENSMUSG00000075478
  
Biological name :Slitrk1
  
Synonyms : Q810C1 / SLIT and NTRK-like family, member 1 / Slitrk1
  
Possible biological names infered from orthology : Q96PX8
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: E3
Gene start: 108908800
Gene end: 108914158
  
Corresponding Affymetrix probe sets: 10422240 (MoGene1.0st)   1428089_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000097897
NCBI entrez gene - 76965     See in Manteia.
MGI - MGI:2679446
RefSeq - NM_199065
RefSeq Peptide - NP_951020
swissprot - B2RXM1
swissprot - Q810C1
Ensembl - ENSMUSG00000075478
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SLITRK1ENSGALG00000016905Gallus gallus
 Q96PX8ENSG00000178235Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q810C0 / Slitrk2 / SLIT and NTRK-like family, member 2 / O96002* / Q9H156*ENSMUSG0000003679042
Q810B8 / Slitrk4 / SLIT and NTRK-like family, member 4 / Q8IW52*ENSMUSG0000004669941
Q810B7 / Slitrk5 / SLIT and NTRK-like protein 5 / O94991* / SLIT and NTRK like family member 5*ENSMUSG0000003321441
Q810B9 / Slitrk3 / Mus musculus SLIT and NTRK-like family, member 3 (Slitrk3), transcript variant 2, mRNA. / O94933* / SLIT and NTRK like family member 3*ENSMUSG0000004830439
Q8C110 / Slitrk6 / SLIT and NTRK-like family, member 6 / Q9H5Y7*ENSMUSG0000004587137
Elfn1 / Q8C8T7 / Protein ELFN1 / P0C7U0* / extracellular leucine rich repeat and fibronectin type III domain containing 1*ENSMUSG0000004898814
Elfn2 / Q68FM6 / Mus musculus leucine rich repeat and fibronectin type III, extracellular 2 (Elfn2), transcript variant 1, mRNA. / Q5R3F8* / extracellular leucine rich repeat and fibronecti...ENSMUSG0000004346013
Lrrc19 / Q8BZT5 / Leucine-rich repeat-containing protein 19 / Q9H756* / leucine rich repeat containing 19*ENSMUSG000000497999


Protein motifs (from Interpro)
Interpro ID Name
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007399 nervous system development IMP
 biological_processGO:0007409 axonogenesis IDA
 biological_processGO:0007416 synapse assembly IEA
 biological_processGO:0030534 adult behavior IMP
 biological_processGO:0035264 multicellular organism growth IMP
 biological_processGO:0042592 homeostatic process IMP
 biological_processGO:0050772 positive regulation of axonogenesis ISS
 biological_processGO:0051965 positive regulation of synapse assembly IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane ISS
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Receptor-type tyrosine-protein phosphatases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Cd14tm1Smg/Cd14tm1Smg,Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3.129S1-CD14tm1Smg

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Cd14tm1Smg/Cd14tm1Smg,Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3.129S1-CD14tm1Smg

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Cd14tm1Smg/Cd14tm1Smg,Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3.129S1-CD14tm1Smg

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi

 MP:0002059 abnormal seminal gland morphology "anomalous structure of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi

 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi

 MP:0003064 decreased coping response "reduced ability to respond productively to a stressful situation" [RGD:Rat Genome Database submission]
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Allelic Composition: Cd14tm1Smg/Cd14tm1Smg,Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3.129S1-CD14tm1Smg

 MP:0003459 increased fear-related response "greater emotional response related to anticipation of specific pain or danger" [CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: Cd14tm1Smg/Cd14tm1Smg,Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3.129S1-CD14tm1Smg

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Cd14tm1Smg/Cd14tm1Smg,Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3.129S1-CD14tm1Smg

 MP:0003964 abnormal noradrenaline level "aberrant concentration of this precursor of epinephrine that is a widespread central and autonomic neurotransmitter" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cd14tm1Smg/Cd14tm1Smg,Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3.129S1-CD14tm1Smg

 MP:0004931 enlarged epididymis "increase in the average size of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd14tm1Smg/Cd14tm1Smg,Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3.129S1-CD14tm1Smg

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Cd14tm1Smg/Cd14tm1Smg,Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3.129S1-CD14tm1Smg

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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