ENSMUSG00000045871


Mus musculus

Features
Gene ID: ENSMUSG00000045871
  
Biological name :Slitrk6
  
Synonyms : Q8C110 / SLIT and NTRK-like family, member 6 / Slitrk6
  
Possible biological names infered from orthology : Q9H5Y7
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: E3
Gene start: 110748580
Gene end: 110755149
  
Corresponding Affymetrix probe sets: 10422244 (MoGene1.0st)   1437231_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000077492
NCBI entrez gene - 239250     See in Manteia.
MGI - MGI:2443198
RefSeq - XM_006519009
RefSeq - NM_175499
RefSeq Peptide - NP_780708
swissprot - Q8C110
swissprot - A6H6M2
Ensembl - ENSMUSG00000045871
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slitrk6ENSDARG00000098769Danio rerio
 SLITRK6ENSGALG00000016904Gallus gallus
 Q9H5Y7ENSG00000184564Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q810B7 / Slitrk5 / SLIT and NTRK-like protein 5 / O94991* / SLIT and NTRK like family member 5*ENSMUSG0000003321442
Q810B8 / Slitrk4 / SLIT and NTRK-like family, member 4 / Q8IW52*ENSMUSG0000004669940
Q810C0 / Slitrk2 / SLIT and NTRK-like family, member 2 / O96002* / Q9H156*ENSMUSG0000003679039
Q810B9 / Slitrk3 / Mus musculus SLIT and NTRK-like family, member 3 (Slitrk3), transcript variant 2, mRNA. / O94933* / SLIT and NTRK like family member 3*ENSMUSG0000004830438
Q810C1 / Slitrk1 / SLIT and NTRK-like family, member 1 / Q96PX8*ENSMUSG0000007547831
Elfn2 / Q68FM6 / Mus musculus leucine rich repeat and fibronectin type III, extracellular 2 (Elfn2), transcript variant 1, mRNA. / Q5R3F8* / extracellular leucine rich repeat and fibronecti...ENSMUSG0000004346014
Elfn1 / Q8C8T7 / Protein ELFN1 / P0C7U0* / extracellular leucine rich repeat and fibronectin type III domain containing 1*ENSMUSG0000004898814
Lrrc19 / Q8BZT5 / Leucine-rich repeat-containing protein 19 / Q9H756* / leucine rich repeat containing 19*ENSMUSG000000497999


Protein motifs (from Interpro)
Interpro ID Name
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001964 startle response IMP
 biological_processGO:0002088 lens development in camera-type eye IMP
 biological_processGO:0002093 auditory receptor cell morphogenesis IMP
 biological_processGO:0007409 axonogenesis IDA
 biological_processGO:0007416 synapse assembly IEA
 biological_processGO:0007601 visual perception IMP
 biological_processGO:0007605 sensory perception of sound IEA
 biological_processGO:0008344 adult locomotory behavior IMP
 biological_processGO:0021562 vestibulocochlear nerve development IMP
 biological_processGO:0031223 auditory behavior IMP
 biological_processGO:0035264 multicellular organism growth IMP
 biological_processGO:0042472 inner ear morphogenesis IMP
 biological_processGO:0043010 camera-type eye development IMP
 biological_processGO:0048812 neuron projection morphogenesis IMP
 biological_processGO:0050896 response to stimulus IEA
 biological_processGO:0051965 positive regulation of synapse assembly IDA
 biological_processGO:0060005 vestibular reflex IMP
 biological_processGO:0060007 linear vestibuloocular reflex IMP
 biological_processGO:0060384 innervation IMP
 biological_processGO:0090102 cochlea development IMP
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane ISS
 cellular_componentGO:0071944 cell periphery IDA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Receptor-type tyrosine-protein phosphatases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Lamb2tm1Jrs/Lamb2tm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Lamb2tm1Jrs/Lamb2tm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Lamb2tm1Jrs/Lamb2tm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
Show

Allelic Composition: Lamb2tm1Jrs/Lamb2tm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002622 abnormal cochlear hair cell morphology "malformation of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Csf3tm1Ard/Csf3tm1Ard,Junbtm3Wag/Junbtm3Wag,Tg(KRT5-cre)1Tak/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C3H * C57BL/6

 MP:0003986 small cochlear ganglion "reduced size of the cochlear ganglion or of the sensory neuron cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Csf3tm1Ard/Csf3tm1Ard,Junbtm3Wag/Junbtm3Wag,Tg(KRT5-cre)1Tak/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C3H * C57BL/6

 MP:0003987 small vestibular ganglion "reduced size of the vestibular ganglion or of the sensory neuron cell bodies associated with the eighth cranial nerve" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Csf3tm1Ard/Csf3tm1Ard,Junbtm3Wag/Junbtm3Wag,Tg(KRT5-cre)1Tak/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C3H * C57BL/6

 MP:0004249 abnormal crista ampullaris morphology "anomaly in the elevation found on the inner surface of the ampullae of each semicircular duct; filaments of the vestibular nerve pass through the crista to reach hair cells on its surface; the hair cells are capped by the cupula, a gelatinous protein-polysaccharide mass" [J:60193, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Csf3tm1Ard/Csf3tm1Ard,Junbtm3Wag/Junbtm3Wag,Tg(KRT5-cre)1Tak/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C3H * C57BL/6

 MP:0004409 abnormal neuroepithelium of ampullary crest "any structural abnormality in the specialized sensory hair cells of the ampullary crest of the ampulla of each semicircular duct" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Csf3tm1Ard/Csf3tm1Ard,Junbtm3Wag/Junbtm3Wag,Tg(KRT5-cre)1Tak/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C3H * C57BL/6

 MP:0004632 abnormal cochlear OHC efferent innervation "any changes in the morphology or number of efferent terminals, occurring as clusters, in the cochlear OHC region; normally, medial olivocochlear neurons, which are primarily found in rostral and ventral periolivary regions, project mainly to the contralateral cochlea, and terminate directly on OHCs" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Csf3tm1Ard/Csf3tm1Ard,Junbtm3Wag/Junbtm3Wag,Tg(KRT5-cre)1Tak/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C3H * C57BL/6

 MP:0004633 abnormal cochlear IHC efferent innervation "any changes in the morphology of the normally dense plexus of efferent terminals that contact radial fibers of the spiral ganglion below cochlear IHCs or of the sparser plexus of terminals positioned around IHC somata; normally, lateral olivocochlear neurons, which are found in and/or around the lateral superior olive, project mainly to the ipsilateral cochlea and terminate mostly on dendritic fibers below IHCs " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Csf3tm1Ard/Csf3tm1Ard,Junbtm3Wag/Junbtm3Wag,Tg(KRT5-cre)1Tak/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C3H * C57BL/6

 MP:0004746 abnormal cochlear IHC afferent innervation "any changes in the morphology or number of afferent terminals and/or their synapses in the cochlear IHC region" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Csf3tm1Ard/Csf3tm1Ard,Junbtm3Wag/Junbtm3Wag,Tg(KRT5-cre)1Tak/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C3H * C57BL/6

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Csf3tm1Ard/Csf3tm1Ard,Junbtm3Wag/Junbtm3Wag,Tg(KRT5-cre)1Tak/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C3H * C57BL/6

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lamb2tm1Jrs/Lamb2tm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011041 abnormal vertical vestibuloocular reflex "any anomaly in the nystagmus or deviation of the eyes in response to stimulation along the vertical axis of the vestibular system" [MGI:smb]
Show

Allelic Composition: Lamb2tm1Jrs/Lamb2tm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Lamb2tm1Jrs/Lamb2tm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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