ENSG00000187758


Homo sapiens

Features
Gene ID: ENSG00000187758
  
Biological name :ADH1A
  
Synonyms : ADH1A / alcohol dehydrogenase 1A (class I), alpha polypeptide / P07327
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: q23
Gene start: 99276367
Gene end: 99291028
  
Corresponding Affymetrix probe sets: 207820_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000209668
NCBI entrez gene - 124     See in Manteia.
OMIM - 103700
RefSeq - NM_000667
RefSeq Peptide - NP_000658
swissprot - P07327
Ensembl - ENSG00000187758
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adh5ENSDARG00000080010Danio rerio
 adh8aENSDARG00000091211Danio rerio
 adh8bENSDARG00000024278Danio rerio
 zgc:63568ENSDARG00000087262Danio rerio
 zgc:77938ENSDARG00000088366Danio rerio
 ADH1CENSGALG00000030614Gallus gallus
 Adh1ENSMUSG00000074207Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ADH1B / P00325 / alcohol dehydrogenase 1B (class I), beta polypeptideENSG0000019661694
ADH1C / P00326 / alcohol dehydrogenase 1C (class I), gamma polypeptideENSG0000024814493
ADH7 / P40394 / alcohol dehydrogenase 7 (class IV), mu or sigma polypeptideENSG0000019634468
ADH5 / P11766 / alcohol dehydrogenase 5 (class III), chi polypeptideENSG0000019789463
ADH6 / P28332 / alcohol dehydrogenase 6 (class V)ENSG0000017295563
ADH4 / P08319 / alcohol dehydrogenase 4 (class II), pi polypeptideENSG0000019809960


Protein motifs (from Interpro)
Interpro ID Name
 IPR002328  Alcohol dehydrogenase, zinc-type, conserved site
 IPR011032  GroES-like superfamily
 IPR013149  Alcohol dehydrogenase, C-terminal
 IPR013154  Alcohol dehydrogenase, N-terminal
 IPR020843  Polyketide synthase, enoylreductase domain
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006066 alcohol metabolic process NAS
 biological_processGO:0006069 ethanol oxidation TAS
 biological_processGO:0017144 drug metabolic process TAS
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IDA
 molecular_functionGO:0004022 alcohol dehydrogenase (NAD) activity TAS
 molecular_functionGO:0004024 alcohol dehydrogenase activity, zinc-dependent IDA
 molecular_functionGO:0004745 retinol dehydrogenase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Abacavir metabolism
RA biosynthesis pathway
Ethanol oxidation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000196616 ADH1B / P00325 / alcohol dehydrogenase 1B (class I), beta polypeptide  / complex
 ENSG00000187758 ADH1A / P07327 / alcohol dehydrogenase 1A (class I), alpha polypeptide  / complex
 ENSG00000248144 ADH1C / P00326 / alcohol dehydrogenase 1C (class I), gamma polypeptide  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr