ENSMUSG00000074207


Mus musculus

Features
Gene ID: ENSMUSG00000074207
  
Biological name :Adh1
  
Synonyms : Adh1 / Alcohol dehydrogenase 1 / P00329
  
Possible biological names infered from orthology : ADH1A / ADH1B / ADH1C / alcohol dehydrogenase 1A (class I), alpha polypeptide / alcohol dehydrogenase 1B (class I), beta polypeptide / alcohol dehydrogenase 1C (class I), gamma polypeptide / P00325 / P00326 / P07327
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: G3
Gene start: 138260991
Gene end: 138290698
  
Corresponding Affymetrix probe sets: 10496438 (MoGene1.0st)   1416225_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000124688
Ensembl peptide - ENSMUSP00000004232
NCBI entrez gene - 11522     See in Manteia.
MGI - MGI:87921
RefSeq - NM_007409
RefSeq Peptide - NP_031435
swissprot - E0CXV3
swissprot - P00329
swissprot - Q3UKA4
Ensembl - ENSMUSG00000074207
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adh5ENSDARG00000080010Danio rerio
 adh8aENSDARG00000091211Danio rerio
 adh8bENSDARG00000024278Danio rerio
 zgc:63568ENSDARG00000087262Danio rerio
 zgc:77938ENSDARG00000088366Danio rerio
 ADH1CENSGALG00000030614Gallus gallus
 ADH1AENSG00000187758Homo sapiens
 ADH1BENSG00000196616Homo sapiens
 ADH1CENSG00000248144Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Adh7 / Q64437 / Alcohol dehydrogenase class 4 mu/sigma chain / P40394* / alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide*ENSMUSG0000005530167
Adh5 / P28474 / Alcohol dehydrogenase class-3 / P11766* / alcohol dehydrogenase 5 (class III), chi polypeptide*ENSMUSG0000002813863
Adh6a / alcohol dehydrogenase 6A (class V) / ADH6* / P28332* / alcohol dehydrogenase 6 (class V)*ENSMUSG0000005305454
Adh4 / Q9QYY9 / Alcohol dehydrogenase 4 / P08319* / alcohol dehydrogenase 4 (class II), pi polypeptide*ENSMUSG0000003779754
Adh6b / alcohol dehydrogenase 6B (class V) / ADH6* / P28332* / alcohol dehydrogenase 6 (class V)*ENSMUSG0000007420636


Protein motifs (from Interpro)
Interpro ID Name
 IPR002328  Alcohol dehydrogenase, zinc-type, conserved site
 IPR011032  GroES-like superfamily
 IPR013149  Alcohol dehydrogenase, C-terminal
 IPR013154  Alcohol dehydrogenase, N-terminal
 IPR020843  Polyketide synthase, enoylreductase domain
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001523 retinoid metabolic process IMP
 biological_processGO:0006068 ethanol catabolic process IMP
 biological_processGO:0006069 ethanol oxidation ISO
 biological_processGO:0032526 response to retinoic acid IDA
 biological_processGO:0033574 response to testosterone IDA
 biological_processGO:0042572 retinol metabolic process IMP
 biological_processGO:0042573 retinoic acid metabolic process IMP
 biological_processGO:0048149 behavioral response to ethanol IMP
 biological_processGO:0048545 response to steroid hormone IDA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane ISO
 molecular_functionGO:0004022 alcohol dehydrogenase (NAD) activity TAS
 molecular_functionGO:0004024 alcohol dehydrogenase activity, zinc-dependent ISO
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Abacavir metabolism
RA biosynthesis pathway
Ethanol oxidation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Apctm1Cip/Apc+,H19tm1Lda/H19+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Adh1tm2Gdu/Adh1tm2Gdu,Adh7tm1Gdu/Adh7tm1Gdu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0005443 abnormal ethanol metabolism "altered ability to metabolize the clear, colorless liquid that is the primary ingredient in alcoholic beverages" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:55555]
Show

Allelic Composition: Adcyap1r1tm1Bbt/Adcyap1r1tm1Bbt
Genetic Background: involves: 129 * C57BL/6J

 MP:0005444 abnormal retinol metabolism "altered ability to metabolize this organic compound that plays an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:55555]
Show

Allelic Composition: Adcyap1r1tm1Bbt/Adcyap1r1tm1Bbt
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Adh1tm2Gdu/Adh1tm2Gdu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Adh1tm2Gdu/Adh1tm2Gdu,Adh7tm1Gdu/Adh7tm1Gdu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adh1tm2Gdu/Adh1tm2Gdu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Adh1tm2Gdu/Adh1tm2Gdu,Adh7tm1Gdu/Adh7tm1Gdu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000074207 Adh1 / P00329 / Alcohol dehydrogenase 1 / ADH1C* / ADH1A* / ADH1B* / P07327* / P00325* / P00326* / alcohol dehydrogenase 1B (class I), beta polypeptide* / alcohol dehydrogenase 1A (class I...  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr