ENSMUSG00000028138


Mus musculus

Features
Gene ID: ENSMUSG00000028138
  
Biological name :Adh5
  
Synonyms : Adh5 / Alcohol dehydrogenase class-3 / P28474
  
Possible biological names infered from orthology : alcohol dehydrogenase 5 (class III), chi polypeptide / P11766
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: G3
Gene start: 138443093
Gene end: 138455499
  
Corresponding Affymetrix probe sets: 10496475 (MoGene1.0st)   1416185_a_at (Mouse Genome 430 2.0 Array)   1443380_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142541
Ensembl peptide - ENSMUSP00000143676
Ensembl peptide - ENSMUSP00000005964
NCBI entrez gene - 11532     See in Manteia.
MGI - MGI:87929
RefSeq - NM_001288578
RefSeq - NM_007410
RefSeq Peptide - NP_001275507
RefSeq Peptide - NP_031436
swissprot - Q6P5I3
swissprot - A0A0G2JDX2
swissprot - P28474
swissprot - A0A0G2JGS3
Ensembl - ENSMUSG00000028138
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adh5ENSDARG00000080010Danio rerio
 adh8aENSDARG00000091211Danio rerio
 adh8bENSDARG00000024278Danio rerio
 zgc:63568ENSDARG00000087262Danio rerio
 zgc:77938ENSDARG00000088366Danio rerio
 ADH5ENSGALG00000012245Gallus gallus
 ADH5ENSG00000197894Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Adh1 / P00329 / Alcohol dehydrogenase 1 / ADH1C* / ADH1A* / ADH1B* / P07327* / P00325* / P00326* / alcohol dehydrogenase 1B (class I), beta polypeptide* / alcohol dehydrogenase 1A (class I...ENSMUSG0000007420763
Adh7 / Q64437 / Alcohol dehydrogenase class 4 mu/sigma chain / P40394* / alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide*ENSMUSG0000005530160
Adh4 / Q9QYY9 / Alcohol dehydrogenase 4 / P08319* / alcohol dehydrogenase 4 (class II), pi polypeptide*ENSMUSG0000003779756
Adh6a / alcohol dehydrogenase 6A (class V) / ADH6* / P28332* / alcohol dehydrogenase 6 (class V)*ENSMUSG0000005305450
Adh6b / alcohol dehydrogenase 6B (class V) / ADH6* / P28332* / alcohol dehydrogenase 6 (class V)*ENSMUSG0000007420633


Protein motifs (from Interpro)
Interpro ID Name
 IPR002328  Alcohol dehydrogenase, zinc-type, conserved site
 IPR011032  GroES-like superfamily
 IPR013149  Alcohol dehydrogenase, C-terminal
 IPR013154  Alcohol dehydrogenase, N-terminal
 IPR014183  Alcohol dehydrogenase class III
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001523 retinoid metabolic process IMP
 biological_processGO:0003016 respiratory system process IMP
 biological_processGO:0006069 ethanol oxidation IEA
 biological_processGO:0018119 peptidyl-cysteine S-nitrosylation IMP
 biological_processGO:0032496 response to lipopolysaccharide IMP
 biological_processGO:0045777 positive regulation of blood pressure IMP
 biological_processGO:0046294 formaldehyde catabolic process IMP
 biological_processGO:0051409 response to nitrosative stress IMP
 biological_processGO:0051775 response to redox state IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 molecular_functionGO:0004022 alcohol dehydrogenase (NAD) activity IDA
 molecular_functionGO:0005504 fatty acid binding IEA
 molecular_functionGO:0008270 zinc ion binding ISO
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0018467 formaldehyde dehydrogenase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051903 S-(hydroxymethyl)glutathione dehydrogenase activity IMP


Pathways (from Reactome)
Pathway description
Ethanol oxidation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001529 abnormal vocalization "an inability, decreased ability or altered ability to produce sound from the vocal organs; or a general increase or decrease in the production of vocal sound" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:85479]
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Allelic Composition: Adgrv1tm1.1(KOMP)Vlcg/Adgrv1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Adgrv1tm1.1(KOMP)Vlcg/Ucd

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tlr3tm1Flv/Tlr3tm1Flv
Genetic Background: involves: C57BL/6

 MP:0002843 decreased blood pressure "decreased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tlr3tm1Flv/Tlr3tm1Flv
Genetic Background: involves: C57BL/6

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Adgrv1tm1.1(KOMP)Vlcg/Adgrv1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Adgrv1tm1.1(KOMP)Vlcg/Ucd

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adgrv1tm1.1(KOMP)Vlcg/Adgrv1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Adgrv1tm1.1(KOMP)Vlcg/Ucd

 MP:0005266 abnormal metabolism "anomalous chemical and physical changes occurring in tissue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tlr3tm1Flv/Tlr3tm1Flv
Genetic Background: involves: C57BL/6

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr3tm1Flv/Tlr3tm1Flv
Genetic Background: involves: C57BL/6

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Adcyap1r1tm1Bbt/Adcyap1r1tm1Bbt
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Adh5tm1.1Llli/Adh5tm1.1Llli,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Adh5tm1.1Llli Speer6-ps1Tg(Alb-cre)21Mgn

Allelic Composition: Adh5tm1Stam/Adh5tm1Stam
Genetic Background: involves: 129

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tlr3tm1Flv/Tlr3tm1Flv
Genetic Background: involves: C57BL/6

Allelic Composition: Adh5tm1.1Llli/Adh5tm1.1Llli,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Adh5tm1.1Llli Speer6-ps1Tg(Alb-cre)21Mgn

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028138 Adh5 / P28474 / Alcohol dehydrogenase class-3 / P11766* / alcohol dehydrogenase 5 (class III), chi polypeptide*  / complex






 

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