ENSMUSG00000055301


Mus musculus

Features
Gene ID: ENSMUSG00000055301
  
Biological name :Adh7
  
Synonyms : Adh7 / Alcohol dehydrogenase class 4 mu/sigma chain / Q64437
  
Possible biological names infered from orthology : alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide / P40394
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: G3
Gene start: 138217760
Gene end: 138233382
  
Corresponding Affymetrix probe sets: 10496425 (MoGene1.0st)   1421058_at (Mouse Genome 430 2.0 Array)   1450110_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000087633
NCBI entrez gene - 11529     See in Manteia.
MGI - MGI:87926
RefSeq - XM_006500920
RefSeq - NM_009626
RefSeq - XM_006500919
RefSeq Peptide - NP_033756
swissprot - Q9D748
swissprot - Q64437
Ensembl - ENSMUSG00000055301
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adh5ENSDARG00000080010Danio rerio
 adh8aENSDARG00000091211Danio rerio
 adh8bENSDARG00000024278Danio rerio
 zgc:63568ENSDARG00000087262Danio rerio
 zgc:77938ENSDARG00000088366Danio rerio
 ADH1CENSGALG00000030614Gallus gallus
 ADH7ENSG00000196344Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Adh1 / P00329 / Alcohol dehydrogenase 1 / ADH1C* / ADH1A* / ADH1B* / P07327* / P00325* / P00326* / alcohol dehydrogenase 1B (class I), beta polypeptide* / alcohol dehydrogenase 1A (class I...ENSMUSG0000007420768
Adh5 / P28474 / Alcohol dehydrogenase class-3 / P11766* / alcohol dehydrogenase 5 (class III), chi polypeptide*ENSMUSG0000002813860
Adh6a / alcohol dehydrogenase 6A (class V) / ADH6* / P28332* / alcohol dehydrogenase 6 (class V)*ENSMUSG0000005305453
Adh4 / Q9QYY9 / Alcohol dehydrogenase 4 / P08319* / alcohol dehydrogenase 4 (class II), pi polypeptide*ENSMUSG0000003779752
Adh6b / alcohol dehydrogenase 6B (class V) / ADH6* / P28332* / alcohol dehydrogenase 6 (class V)*ENSMUSG0000007420636


Protein motifs (from Interpro)
Interpro ID Name
 IPR002328  Alcohol dehydrogenase, zinc-type, conserved site
 IPR011032  GroES-like superfamily
 IPR013149  Alcohol dehydrogenase, C-terminal
 IPR013154  Alcohol dehydrogenase, N-terminal
 IPR020843  Polyketide synthase, enoylreductase domain
 IPR028635  Alcohol dehydrogenase family, zinc-type, class-IV subfamily
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001523 retinoid metabolic process IEA
 biological_processGO:0006068 ethanol catabolic process IMP
 biological_processGO:0006069 ethanol oxidation IEA
 biological_processGO:0009617 response to bacterium IEA
 biological_processGO:0010430 fatty acid omega-oxidation IEA
 biological_processGO:0042572 retinol metabolic process IMP
 biological_processGO:0042573 retinoic acid metabolic process IMP
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0055114 oxidation-reduction process ISO
 biological_processGO:1900116 extracellular negative regulation of signal transduction IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 molecular_functionGO:0004022 alcohol dehydrogenase (NAD) activity TAS
 molecular_functionGO:0004024 alcohol dehydrogenase activity, zinc-dependent IEA
 molecular_functionGO:0004031 aldehyde oxidase activity IEA
 molecular_functionGO:0004745 retinol dehydrogenase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity TAS
 molecular_functionGO:0019841 retinol binding IEA
 molecular_functionGO:0035276 ethanol binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048019 receptor antagonist activity IEA


Pathways (from Reactome)
Pathway description
Ethanol oxidation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000819 abnormal olfactory bulb morphology "malformation or absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:16461]
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Allelic Composition: Dmdmdx/Y,Terctm1Rdp/Terc+
Genetic Background: involves: 129/Sv * C57BL/6J * C57BL/10ScSn * SJL

 MP:0000836 abnormal substantia nigra morphology "malformation or absence of the layer of gray substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis)" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dmdmdx/Y,Terctm1Rdp/Terc+
Genetic Background: involves: 129/Sv * C57BL/6J * C57BL/10ScSn * SJL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Dmdmdx/Y,Terctm1Rdp/Terc+
Genetic Background: involves: 129/Sv * C57BL/6J * C57BL/10ScSn * SJL

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Adh1tm2Gdu/Adh1tm2Gdu,Adh7tm1Gdu/Adh7tm1Gdu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dmdmdx/Y,Terctm1Rdp/Terc+
Genetic Background: involves: 129/Sv * C57BL/6J * C57BL/10ScSn * SJL

Allelic Composition: Adh7tm1Gdu/Adh7+
Genetic Background: B6.129(Cg)-Adh7tm1Gdu

 MP:0001906 increased dopamine level "greater than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dmdmdx/Y,Terctm1Rdp/Terc+
Genetic Background: involves: 129/Sv * C57BL/6J * C57BL/10ScSn * SJL

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Adh7tm1Gdu/Adh7+
Genetic Background: B6.129(Cg)-Adh7tm1Gdu

 MP:0005443 abnormal ethanol metabolism "altered ability to metabolize the clear, colorless liquid that is the primary ingredient in alcoholic beverages" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:55555]
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Allelic Composition: Adcyap1r1tm1Bbt/Adcyap1r1tm1Bbt
Genetic Background: involves: 129 * C57BL/6J

 MP:0005444 abnormal retinol metabolism "altered ability to metabolize this organic compound that plays an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:55555]
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Allelic Composition: Adcyap1r1tm1Bbt/Adcyap1r1tm1Bbt
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Adh1tm2Gdu/Adh1tm2Gdu,Adh7tm1Gdu/Adh7tm1Gdu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0008544 impaired olfaction "reduced ability to detect odors" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Dmdmdx/Y,Terctm1Rdp/Terc+
Genetic Background: involves: 129/Sv * C57BL/6J * C57BL/10ScSn * SJL

 MP:0009746 enhanced behavioral response to xenobiotic "increased sensitivity to a foreign compound capable of inducing the appearance of behavioral response, such as consumption preference, induced hyperactivity or stereotypic behavior, or reduced dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dmdmdx/Y,Terctm1Rdp/Terc+
Genetic Background: involves: 129/Sv * C57BL/6J * C57BL/10ScSn * SJL

Allelic Composition: Adh7tm1Gdu/Adh7+
Genetic Background: B6.129(Cg)-Adh7tm1Gdu

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Adcyap1r1tm1Bbt/Adcyap1r1tm1Bbt
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Adh1tm2Gdu/Adh1tm2Gdu,Adh7tm1Gdu/Adh7tm1Gdu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0011232 abnormal vitamin A level "any anomaly in the concentration of any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid; animals can not synthesize vitamin A de novo, but form it through oxidative cleavage of carotenoids supplied in the diet" [GO:0035238]
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Allelic Composition: Adcyap1r1tm1Bbt/Adcyap1r1tm1Bbt
Genetic Background: involves: 129 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000055301 Adh7 / Q64437 / Alcohol dehydrogenase class 4 mu/sigma chain / P40394* / alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide*  / complex






 

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