ENSG00000196632


Homo sapiens

Features
Gene ID: ENSG00000196632
  
Biological name :WNK3
  
Synonyms : Q9BYP7 / WNK3 / WNK lysine deficient protein kinase 3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: -1
Band: p11.22
Gene start: 54192823
Gene end: 54358642
  
Corresponding Affymetrix probe sets: 1555248_a_at (Human Genome U133 Plus 2.0 Array)   232282_at (Human Genome U133 Plus 2.0 Array)   236236_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000481888
Ensembl peptide - ENSP00000364301
Ensembl peptide - ENSP00000364312
Ensembl peptide - ENSP00000401816
Ensembl peptide - ENSP00000346667
NCBI entrez gene - 65267     See in Manteia.
OMIM - 300358
RefSeq - XM_017029745
RefSeq - XM_011530802
RefSeq - XM_017029741
RefSeq - XM_017029742
RefSeq - XM_017029743
RefSeq - XM_017029744
RefSeq - NM_001002838
RefSeq - NM_020922
RefSeq - XM_006724593
RefSeq Peptide - NP_001002838
RefSeq Peptide - NP_065973
swissprot - B1AQN8
swissprot - Q9BYP7
swissprot - A0A087WYK2
Ensembl - ENSG00000196632
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01069040.1ENSDARG00000111945Danio rerio
 Wnk3ENSMUSG00000041245Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
WNK2 / Q9Y3S1 / WNK lysine deficient protein kinase 2ENSG0000016523836
WNK1 / Q9H4A3 / WNK lysine deficient protein kinase 1ENSG0000006023735
WNK4 / Q96J92 / WNK lysine deficient protein kinase 4ENSG0000012656227
NRBP1 / Q9UHY1 / nuclear receptor binding protein 1ENSG000001152169
NRBP2 / Q9NSY0 / nuclear receptor binding protein 2ENSG000001851898


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR024678  Serine/threonine-protein kinase OSR1/WNK, CCT domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0010765 positive regulation of sodium ion transport IDA
 biological_processGO:0010800 positive regulation of peptidyl-threonine phosphorylation IDA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0032414 positive regulation of ion transmembrane transporter activity IDA
 biological_processGO:0035556 intracellular signal transduction ISS
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0051928 positive regulation of calcium ion transport IMP
 biological_processGO:0072659 protein localization to plasma membrane IMP
 biological_processGO:0090188 negative regulation of pancreatic juice secretion IEA
 biological_processGO:0090279 regulation of calcium ion import IMP
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IDA
 biological_processGO:2000651 positive regulation of sodium ion transmembrane transporter activity IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0005912 adherens junction IEA
 cellular_componentGO:0005923 bicellular tight junction IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019869 chloride channel inhibitor activity IDA


Pathways (from Reactome)
Pathway description
Stimuli-sensing channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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