ENSMUSG00000041245


Mus musculus

Features
Gene ID: ENSMUSG00000041245
  
Biological name :Wnk3
  
Synonyms : Q80XP9 / Wnk3 / WNK lysine deficient protein kinase 3
  
Possible biological names infered from orthology : Q9BYP7
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: F3
Gene start: 151198078
Gene end: 151320152
  
Corresponding Affymetrix probe sets: 10602428 (MoGene1.0st)   1443924_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000138822
Ensembl peptide - ENSMUSP00000138839
Ensembl peptide - ENSMUSP00000139037
Ensembl peptide - ENSMUSP00000139255
NCBI entrez gene - 279561     See in Manteia.
MGI - MGI:2652875
RefSeq - XM_011247830
RefSeq - NM_001271678
RefSeq - NM_001271679
RefSeq - XM_006528871
RefSeq - XM_006528872
RefSeq - XM_006528873
RefSeq - XM_006528874
RefSeq - XM_011247829
RefSeq - XM_006528870
RefSeq Peptide - NP_001258608
RefSeq Peptide - NP_001258607
swissprot - Q80XP9
swissprot - V9GWU7
swissprot - V9GXP7
Ensembl - ENSMUSG00000041245
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01069040.1ENSDARG00000111945Danio rerio
 WNK3ENSG00000196632Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Wnk2 / WNK lysine deficient protein kinase 2 / Q9Y3S1*ENSMUSG0000003798936
Wnk1 / P83741 / WNK lysine deficient protein kinase 1 / Q9H4A3*ENSMUSG0000004596235
Wnk4 / Q80UE6 / WNK lysine deficient protein kinase 4 / Q96J92*ENSMUSG0000003511226
Nrbp1 / Q99J45 / Mus musculus nuclear receptor binding protein 1 (Nrbp1), transcript variant 1, mRNA. / Q9UHY1* / nuclear receptor binding protein 1*ENSMUSG000000291488
Nrbp2 / Q91V36 / Mus musculus nuclear receptor binding protein 2 (Nrbp2), transcript variant 1, mRNA. / Q9NSY0* / nuclear receptor binding protein 2*ENSMUSG000000755904


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR024678  Serine/threonine-protein kinase OSR1/WNK, CCT domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0010765 positive regulation of sodium ion transport IEA
 biological_processGO:0010800 positive regulation of peptidyl-threonine phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0032414 positive regulation of ion transmembrane transporter activity IEA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0051928 positive regulation of calcium ion transport IEA
 biological_processGO:0072659 protein localization to plasma membrane IEA
 biological_processGO:0090188 negative regulation of pancreatic juice secretion IMP
 biological_processGO:0090279 regulation of calcium ion import IEA
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IEA
 biological_processGO:2000651 positive regulation of sodium ion transmembrane transporter activity IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0005912 adherens junction IDA
 cellular_componentGO:0005923 bicellular tight junction IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019869 chloride channel inhibitor activity IEA


Pathways (from Reactome)
Pathway description
Stimuli-sensing channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mov10l1tm1.2Jw/Mov10l1tm1.2Jw
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0002843 decreased blood pressure "decreased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo/Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo
Genetic Background: involves: 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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