ENSMUSG00000035112


Mus musculus

Features
Gene ID: ENSMUSG00000035112
  
Biological name :Wnk4
  
Synonyms : Q80UE6 / Wnk4 / WNK lysine deficient protein kinase 4
  
Possible biological names infered from orthology : Q96J92
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: D
Gene start: 101260567
Gene end: 101277409
  
Corresponding Affymetrix probe sets: 10381311 (MoGene1.0st)   1427196_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000131954
Ensembl peptide - ENSMUSP00000132123
Ensembl peptide - ENSMUSP00000099397
Ensembl peptide - ENSMUSP00000129666
Ensembl peptide - ENSMUSP00000131298
NCBI entrez gene - 69847     See in Manteia.
MGI - MGI:1917097
RefSeq - XM_006534136
RefSeq - XM_006534138
RefSeq - XM_006534139
RefSeq - XM_006534141
RefSeq - XM_017314744
RefSeq - XM_006534137
RefSeq - NM_175638
RefSeq Peptide - NP_783569
swissprot - Q80UE6
swissprot - F6X7K7
swissprot - F6Z709
swissprot - E9PZ38
swissprot - E9Q470
Ensembl - ENSMUSG00000035112
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wnk4bENSDARG00000088967Danio rerio
 WNK4ENSGALG00000032191Gallus gallus
 WNK4ENSG00000126562Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Wnk1 / P83741 / WNK lysine deficient protein kinase 1 / Q9H4A3*ENSMUSG0000004596242
Wnk2 / WNK lysine deficient protein kinase 2 / Q9Y3S1*ENSMUSG0000003798940
Wnk3 / Q80XP9 / WNK lysine deficient protein kinase 3 / Q9BYP7*ENSMUSG0000004124537
Nrbp1 / Q99J45 / Mus musculus nuclear receptor binding protein 1 (Nrbp1), transcript variant 1, mRNA. / Q9UHY1* / nuclear receptor binding protein 1*ENSMUSG0000002914810
Nrbp2 / Q91V36 / Mus musculus nuclear receptor binding protein 2 (Nrbp2), transcript variant 1, mRNA. / Q9NSY0* / nuclear receptor binding protein 2*ENSMUSG000000755904


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR024678  Serine/threonine-protein kinase OSR1/WNK, CCT domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006811 ion transport IDA
 biological_processGO:0006821 chloride transport IDA
 biological_processGO:0008104 protein localization IDA
 biological_processGO:0010766 negative regulation of sodium ion transport IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030644 cellular chloride ion homeostasis TAS
 biological_processGO:0035556 intracellular signal transduction ISS
 biological_processGO:0050794 regulation of cellular process IDA
 biological_processGO:0050801 ion homeostasis IEA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0070294 renal sodium ion absorption IEA
 biological_processGO:0072156 distal tubule morphogenesis IEA
 biological_processGO:0090188 negative regulation of pancreatic juice secretion IMP
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005923 bicellular tight junction IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019869 chloride channel inhibitor activity IEA


Pathways (from Reactome)
Pathway description
Stimuli-sensing channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000231 hypertension "sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: ICR

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Msx2tm1Rilm/Msx2tm1Rilm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA/J

 MP:0002667 decreased circulating aldosterone level "decreased blood concentration of this hormone, secreted by the adrenal cortex, in the bloodstream; regulates sodium conservation and potassium secretion in the distal renal tubule" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Msx2tm1Rilm/Msx2tm1Rilm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA/J

 MP:0003017 decreased circulating bicarbonate level "reduced concentration of inorganic salts that contain the -HCO3 radical in the circulation, which are an important factor in regulating the pH of the blood " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: ICR

 MP:0003020 decreased circulating chloride level "reduced concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Wnk4tm1Pfi/Wnk4tm1Pfi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0003028 alkalosis "a pathological condition characterized by a decrease in the hydrogen ion concentration of arterial blood; caused by an increase in the concentration of alkaline compounds, or by a decrease in the concentration of acidic compounds or carbon dioxide to the body fluids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Wnk4tm1Pfi/Wnk4tm1Pfi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0003031 acidosis "a pathological state characterized by an increase in the hydrogen ion concentration of arterial blood; caused by an decrease in the concentration of alkaline compounds, or by a increase in the concentration of acidic compounds or carbon dioxide to the body fluids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: ICR

 MP:0003352 increased circulating renin level "elevated blood concentration of this enzyme which is secreted by the kidney; it cleaves a bond in angiotensionogen to generate angiotensin I " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Wnk4tm1Pfi/Wnk4tm1Pfi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0004119 hypokalemia "excessively low concentrations of potassium in the circulating blood; may be chronic or due to gastrointestinal and kidney depletion due to infection" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Wnk4tm1Pfi/Wnk4tm1Pfi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0005502 abnormal urinary system physiology "functional anomaly of any of the organs involved in the production or excretion of urine " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Msx2tm1Rilm/Msx2tm1Rilm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA/J

 MP:0005618 decreased potassium excretion "less than the normal amount of this alkaline metallic element, the most abundant intracellular ion, voided by the kidneys" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: ICR

 MP:0005619 increased potassium excretion "greater than the normal amount of this alkaline metallic element, the most abundant intracellular ion, voided by the kidneys" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Ikzf1tm1Kge/Ikzf1tm1Kge
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Wnk4tm1Pfi/Wnk4tm1Pfi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0005627 increased circulating potassium level "greater than the normal concentration in the blood of this alkaline metallic element, the most abundant intracellular ion; anomalies in the extracellular (circulating) concentration have important implications for the function of excitable tissues, such as nerve and muscle" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: ICR

 MP:0006264 decreased systolic blood pressure "abnormal decrease in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887]
Show

Allelic Composition: Ikzf1tm1Kge/Ikzf1tm1Kge
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0006316 increased urine sodium level "higher than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ikzf1tm1Kge/Ikzf1tm1Kge
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Wnk4tm1Pfi/Wnk4tm1Pfi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Wnk4tm1Pfi/Wnk4tm1Pfi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Wnk4tm1Pfi/Wnk4tm1Pfi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Wnk4tm1Pfi/Wnk4tm1Pfi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0010093 decreased circulating magnesium level "a reduction in the blood concentration of magnesium" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Wnk4tm1Pfi/Wnk4tm1Pfi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0011459 increased urine chloride ion level "abnormally large amounts of chloride ion in the urine" [MGI:csmith]
Show

Allelic Composition: Wnk4tm1Pfi/Wnk4tm1Pfi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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