ENSMUSG00000029148


Mus musculus

Features
Gene ID: ENSMUSG00000029148
  
Biological name :Nrbp1
  
Synonyms : Mus musculus nuclear receptor binding protein 1 (Nrbp1), transcript variant 1, mRNA. / Nrbp1 / Q99J45
  
Possible biological names infered from orthology : nuclear receptor binding protein 1 / Q9UHY1
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: B1
Gene start: 31240864
Gene end: 31251566
  
Corresponding Affymetrix probe sets: 10520734 (MoGene1.0st)   10520753 (MoGene1.0st)   1423864_at (Mouse Genome 430 2.0 Array)   1432474_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000031034
Ensembl peptide - ENSMUSP00000144415
Ensembl peptide - ENSMUSP00000144292
Ensembl peptide - ENSMUSP00000143899
Ensembl peptide - ENSMUSP00000143872
NCBI entrez gene - 192292     See in Manteia.
MGI - MGI:2183436
RefSeq - XM_017320730
RefSeq - NM_001347326
RefSeq - NM_147201
RefSeq Peptide - NP_001334255
RefSeq Peptide - NP_671734
swissprot - D3YUV1
swissprot - A0A0J9YUZ6
swissprot - A0A0J9YTX8
swissprot - A0A0J9YUQ4
swissprot - Q99J45
Ensembl - ENSMUSG00000029148
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nrbp1ENSDARG00000056089Danio rerio
 NRBP1ENSGALG00000016512Gallus gallus
 NRBP1ENSG00000115216Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Wnk2 / WNK lysine deficient protein kinase 2 / Q9Y3S1*ENSMUSG0000003798928
Wnk1 / P83741 / WNK lysine deficient protein kinase 1 / Q9H4A3*ENSMUSG0000004596228
Nrbp2 / Q91V36 / Mus musculus nuclear receptor binding protein 2 (Nrbp2), transcript variant 1, mRNA. / Q9NSY0* / nuclear receptor binding protein 2*ENSMUSG0000007559027
Wnk3 / Q80XP9 / WNK lysine deficient protein kinase 3 / Q9BYP7*ENSMUSG0000004124526
Wnk4 / Q80UE6 / WNK lysine deficient protein kinase 4 / Q96J92*ENSMUSG0000003511224


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR011009  Protein kinase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport IBA
 biological_processGO:0035556 intracellular signal transduction IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0012505 endomembrane system ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IDA


Pathways (from Reactome)
Pathway description
Nuclear Receptor transcription pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
Show

Allelic Composition: Arpc3Gt(XG476)Byg/Arpc3Gt(XG476)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.2Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.1Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J

 MP:0000490 abnormal crypts of Lieberkuhn morphology "malformation or defects in the tubular intestinal glands found in the mucosal membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.2Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.1Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J

 MP:0000511 abnormal intestinal mucosa morphology "structural or developmental anomalies of the mucous lining of the intestine; this consists of epithelium, lamina, propria, and a layer of smooth muscle cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.2Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.1Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.2Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.1Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.2Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.1Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.2Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.1Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.2Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.1Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J

 MP:0003049 abnormal lumbar vertebrae morphology "malformation of any or all of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Enhotm1.1Butl/Enho+
Genetic Background: B6.Cg-Enhotm1.1Butl

 MP:0003288 intestinal edema "an accumulation of an excessive amount of serous fluid in the intestine or intestinal cells " [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.2Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.1Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J

 MP:0003449 abnormal intestinal goblet cells "malformation of the unicellular mucin-secreting glands" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95282]
Show

Allelic Composition: Arpc3Gt(XG476)Byg/Arpc3Gt(XG476)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.2Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.1Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J

 MP:0004843 abnormal Paneth cell morphology "any structural anomaly of the large secretory cells containing coarse granules found at the base of the crypts of Lieberkuhn in the small intestine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Arpc3Gt(XG476)Byg/Arpc3Gt(XG476)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008714 lung carcinoma "a malignant neoplasm of the ling, arising from epithelial cells, usually glandular or squamous" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.2Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.1Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J

 MP:0008883 abnormal enterocyte proliferation "anomaly in the ability of the enterocyte cell population to undergo expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.2Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.1Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J

 MP:0009511 distended stomach "an expansion in the volume of the sac-like structure of the digestive canal between the esophagus and the small intestine, as by stretching or distention" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.2Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.1Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J

 MP:0010052 increased grip strength "greater ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Enhotm1.1Butl/Enho+
Genetic Background: B6.Cg-Enhotm1.1Butl

 MP:0010279 increased gastrointestinal tumor incidence "greater than the expected number of tumors originating in the gastrointestinal system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.2Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.1Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J

 MP:0010802 abnormal intestinal enteroendocrine cell morphology "any structural anomaly of the various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the intestinal tract" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.2Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.1Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Arpc3Gt(XG476)Byg/Arpc3Gt(XG476)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Nphp1tm1.1(KOMP)Vlcg/Nphp1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Nphp1tm1.1(KOMP)Vlcg/Ucd

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.2Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.1Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J

 MP:0014077 ectopic Paneth cells "abnormal position of the large secretory cells containing coarse granules normally confined to the base of the crypts of Lieberkuhn in the small intestine" [MGI:Anna]
Show

Allelic Composition: Arpc3Gt(XG476)Byg/Arpc3Gt(XG476)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.2Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Nrbp1tm1.1Dja/Nrbp1tm1.1Dja,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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